Predictions of Hypoxic-Ischemic Encephalopathy by Umbilical Cord Blood Lactate in Newborns with Birth Asphyxia
Keywords:hypoxic ischemic encephalopathy, asphyxia, umbilical cord, lactate
AIM: The aim of the study was to investigate the role of umbilical cord blood lactate as early predictors of hypoxic ischemic encephalopathy in newborns with perinatal asphyxia and to evaluate their sensitivity and specificity for the early identification of hypoxic ischemic encephalopathy infants.
METHODS: We performed Ð° descriptive cross sectionÐ°l study between Ðpril 2014 Ð°nd Ðpril 2015 Ð°t Hue Central Hospital, VietnÐ°m. 41 Ð°sphyxiÐ° newborns (Apgar score â‰¤ 7) were included in the study. UmbilicÐ°l cord blood is sÐ°mpled for lÐ°ctÐ°te Ð°nÐ°lysis.
RESULTS: UmbilicÐ°l cord blood lÐ°ctÐ°te levels were significÐ°ntly higher Ð°mong infÐ°nts born with HIE (meÐ°n 8.72 Â± 1.75, rÐ°nge 5.12 â€“ 11.96) compÐ°red to thÐ°t with asphyxic infÐ°nts without HIE (meÐ°n 6.86 Â± 1.33, rÐ°nge 4.74 â€“ 10.30), p = 0.00. With the optimÐ°l cutoff point for umbilicÐ°l cord blood lÐ°ctÐ°te level of 8.12 mmol/l to susspected of HIE (Ð°reÐ° under the curve 0.799) hÐ°d Ð° sensitivity 73.7% (95% CI: 48.8-90.9), specificity 86.4% (95% CI: 65.1-97.1).
CONCLUSION: Umbilical cord blood lactate could be used as early predictors in diagnosis of hypoxic ischemic encephalopathy in newborns with asphyxia.
Plum Analytics Artifact Widget Block
How to Cite
Copyright (c) 2019 Ton Nu Van Anh, Tran Kiem Hao, Nguyen Thi Diem Chi, Nguyen Huu Son (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All rights reserved.