The Difference in Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Preeclampsia

Authors

  • Roza Sriyanti Postgraduate Biomedical Science, Faculty of Medicine, Andalas University, Padang, Indonesia; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Dr M. Djamil Central General Hospital, Padang, Indonesia
  • Johanes C. Mose Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University, Hasan Sadikin Bandung, Indonesia
  • Masrul Masrul Department of Nutrition, Faculty of Medicine, Andalas University, Padang, Indonesia
  • Netti Suharti Department of Microbiology, Faculty of Medicine, Andalas University, Padang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.601

Keywords:

HIF-1α levels, Preeclampsia onset, Pregnancy

Abstract

BACKGROUND: Preeclampsia can be divided into early (EOPE) and late (LOPE) onset preeclampsia. Preeclampsia is related to the failure of placentation. Accumulation of hypoxia-inducible factors (HIF)-1α is commonly an acute and beneficial respond to hypoxia, while chronically elevated is associated with preeclampsia.

AIM: This study aims to evaluate the serum levels of HIF-1α in preeclampsia and normal pregnancy, and to compare the difference between early-onset and late-onset preeclampsia.

METHODS: A cross-sectional comparative study was conducted among a total of 69 pregnant women at ≥ 20 weeks of gestation, were recruited at obstetrics and gynaecology department at Dr M. Djamil Padang Hospital, network hospitals, health centres. They were divided into three groups early-onset preeclampsia, late-onset preeclampsia, and normal pregnancy. Preeclampsia was diagnosed using International Guidelines. Data were analysed by SPSS 24 program; data are presented as median and range or as mean ± standard deviation. One-way ANOVA test was used to determine the relationship between HIF-1α levels with the onset of preeclampsia.

RESULTS: The results showed that the mean maternal serum HIF-1α levels in early-onset preeclampsia (EOPE), late-onset preeclampsia (LOPE), and normal pregnancy were 1366.96 ± 733.40 pg/ml, 916.87 ± 466.06 pg/ml, and 716.77 ± 541.08 pg/ml. Serum HIF-1α levels were higher in early-onset preeclampsia (EOPE), and late-onset preeclampsia (LOPE) compared to normal pregnancy. Among preeclampsia patients, serum HIF-1α was higher in EOPE than LOPE women. Statistical analysis revealed a significant difference in mean maternal serum HIF-1α between early-onset preeclampsia, late-onset preeclampsia, and normal pregnancy (p < 0.05).

CONCLUSION: This study concluded that there is a significantly different level of HIF-1α between in early-onset preeclampsia, late-onset preeclampsia and normal pregnancy. Early-onset preeclampsia is the highest levels of serum HIF-1α.

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Published

2019-08-06

How to Cite

1.
Sriyanti R, Mose JC, Masrul M, Suharti N. The Difference in Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Preeclampsia. Open Access Maced J Med Sci [Internet]. 2019 Aug. 6 [cited 2024 Apr. 23];7(13):2133-7. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.601

Issue

Section

B - Clinical Sciences

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