The Difference in Maternal Serum Hypoxia-Inducible Factors-1Î± Levels between Early Onset and Late-Onset Preeclampsia

Roza Sriyanti; Johanes C. Mose; Masrul Masrul; Netti Suharti

doi:10.3889/oamjms.2019.601

Authors

Roza Sriyanti Postgraduate Biomedical Science, Faculty of Medicine, Andalas University, Padang, Indonesia; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Dr M. Djamil Central General Hospital, Padang, Indonesia
Johanes C. Mose Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University, Hasan Sadikin Bandung, Indonesia
Masrul Masrul Department of Nutrition, Faculty of Medicine, Andalas University, Padang, Indonesia
Netti Suharti Department of Microbiology, Faculty of Medicine, Andalas University, Padang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.601

Keywords:

HIF-1Î± levels, Preeclampsia onset, Pregnancy

Abstract

BACKGROUND: Preeclampsia can be divided into early (EOPE) and late (LOPE) onset preeclampsia. Preeclampsia is related to the failure of placentation. Accumulation of hypoxia-inducible factors (HIF)-1Î± is commonly an acute and beneficial respond to hypoxia, while chronically elevated is associated with preeclampsia.

AIM: This study aims to evaluate the serum levels of HIF-1Î± in preeclampsia and normal pregnancy, and to compare the difference between early-onset and late-onset preeclampsia.

METHODS: A cross-sectional comparative study was conducted among a total of 69 pregnant women at â‰¥ 20 weeks of gestation, were recruited at obstetrics and gynaecology department at Dr M. Djamil Padang Hospital, network hospitals, health centres. They were divided into three groups early-onset preeclampsia, late-onset preeclampsia, and normal pregnancy. Preeclampsia was diagnosed using International Guidelines. Data were analysed by SPSS 24 program; data are presented as median and range or as mean Â± standard deviation. One-way ANOVA test was used to determine the relationship between HIF-1Î± levels with the onset of preeclampsia.

RESULTS: The results showed that the mean maternal serum HIF-1Î± levels in early-onset preeclampsia (EOPE), late-onset preeclampsia (LOPE), and normal pregnancy were 1366.96 Â± 733.40 pg/ml, 916.87 Â± 466.06 pg/ml, and 716.77 Â± 541.08 pg/ml. Serum HIF-1Î± levels were higher in early-onset preeclampsia (EOPE), and late-onset preeclampsia (LOPE) compared to normal pregnancy. Among preeclampsia patients, serum HIF-1Î± was higher in EOPE than LOPE women. Statistical analysis revealed a significant difference in mean maternal serum HIF-1Î± between early-onset preeclampsia, late-onset preeclampsia, and normal pregnancy (p < 0.05).

CONCLUSION: This study concluded that there is a significantly different level of HIF-1Î± between in early-onset preeclampsia, late-onset preeclampsia and normal pregnancy. Early-onset preeclampsia is the highest levels of serum HIF-1Î±.