MicroRNAs as Potential Biomarkers for Childhood Epilepsy

Authors

  • Hala G. Elnady Child Health Department, Medical Research Division, National Research Centre, Giza, Egypt
  • Naglaa Abdelmoneam Pediatrics Department, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt
  • Eman Eissa Immunogenetics Department, Human Genetics & Genome Research Division, National Research Centre, Giza, Egypt
  • Enas R. Abdel Hamid Child Health Department, Medical Research Division, National Research Centre, Giza, Egypt
  • Dina Abu Zeid Child Health Department, Medical Research Division, National Research Centre, Giza, Egypt
  • Assem M. Abo Shanab Immunogenetics Department, Human Genetics & Genome Research Division, National Research Centre, Giza, Egypt
  • Hanan Atta Child Health Department, Medical Research Division, National Research Centre, Giza, Egypt
  • Naglaa M. Kholoussi Immunogenetics Department, Human Genetics & Genome Research Division, National Research Centre, Giza, Egypt

DOI:

https://doi.org/10.3889/oamjms.2019.634

Keywords:

Children, Epilepsy, miR-106b, miR-146a, Biomarker

Abstract

BACKGROUND: Epilepsy is the most frequent chronic neurologic condition in childhood. Its clinical diagnosis is based on electroencephalograms (EEG) and neuroimaging techniques. MicroRNAs (miRNAs) modulate gene expression of several genes and are aberrantly expressed in several diseases.

AIM: Evaluation of using circulating miR-106b and miR-146a as diagnostic and prognostic biomarkers in children patients with epilepsy.

METHODS: Thirty epileptic children and twenty controls were enrolled in our study. They were assessed for the expression pattern of miR-106b and miR-146a in plasma using quantitative real-time PCR and determination of plasma Immunoglobulin levels.

RESULTS: MiR-146a and miR-106b expression patterns were significantly up-regulated in children patients than that in normal controls. Plasma Immunoglobulins were differentially expressed in epileptic patients in comparison with healthy controls. No correlations were found between expression levels of miRNAs (miR-146a and miR-106b) and clinical data or immunoglobulin levels in children patients with epilepsy.

CONCLUSION: Our findings suggest that up-regulated plasma miR-106b and miR-146a could be used as biomarkers for epilepsy evaluation.

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Published

2019-12-10

How to Cite

1.
Elnady HG, Abdelmoneam N, Eissa E, Abdel Hamid ER, Abu Zeid D, Abo Shanab AM, Atta H, Kholoussi NM. MicroRNAs as Potential Biomarkers for Childhood Epilepsy. Open Access Maced J Med Sci [Internet]. 2019 Dec. 10 [cited 2024 Mar. 28];7(23):3965-9. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.634

Issue

Section

A - Basic Science

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