The Effects of Magnesium â€“ Melatonin - Vit B Complex Supplementation in Treatment of Insomnia
Keywords:insomnia, magnesium, melatonin, Athens insomnia scale, supplement
Insomnia means difficulty in falling asleep and/or stays asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The study included 60 patients diagnosed with insomnia. The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 Î¼g vit B12, melatonin 1 mg, Extrafolate-S 600 Î¼g) once a day 1 hour before sleep, during the 3 months. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score â‰¥ 6). Mean AIS score at zero points was 14,93 Â± 3,778 in the study group and 14,37 Â± 4,081 in the control group (p = 0,476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10,50 Â± 4,21 corresponding to mild insomnia, while median AIS score in the control group was 15,13 Â± 3,76 which is referred to moderate insomnia, and difference among groups was significant (p = 0,000). Our foundingâ€™s indicating that 3 months of the Magnesium- melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause.
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Copyright (c) 2019 Gorica Djokic, Petar Vojvodic, Davor Korcok, Anita Agic, Anica Rankovic, Vladan Djordjevic, Aleksandra Vojvodic, Tatjana Vlaskovic-Jovicevic, Zorica Peric-Hajzler, Jovana Vojvodic, Dusica Matovic, Goran Sijan, Uwe Wollina, Michael Tirant, Van Thuong Nguyen, Massimo Fioranelli, Torello Lotti (Author)
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