Effect of Phaleria Macrocarpa Flesh Fruits Extract on MDA Level, SGOT and SGPT Activity in Serum of Experimental Rats Contaminated by Cd (II) Ion

Ali Napiah  Nasution; Hermansyah  Aziz; Djong Hon  Tjong; Rahmiana  Zein

doi:10.3889/oamjms.2019.786

Authors

Ali Napiah Nasution Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia; Department of Tropical Medicine, Faculty of Medicine, University of Prima Indonesia, Medan, Indonesia
Hermansyah Aziz Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia
Djong Hon Tjong Department of Biology, Faculty of Mathematics and Natural Science, Andalas University, Padang, Indonesia
Rahmiana Zein Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia; Department of Environmental Analytical Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.786

Keywords:

Phaleria macrocarpa fruit extract, Cd (II) ion, MDA, SGOT, SGPT

Abstract

BACKGROUND: Cd (II) ion is a heavy metal that has a toxic ability in the human body. P. macrocarpa has been used as anticancer, Diabetes Mellitus and antimicrobe because it consists of flavonoid, steroid, and tannin.

AIM: The purpose of this study was to investigate the effectiveness of P. macrocarpa fruits extract as an antidote for the toxicity of Cd (II) in the liver of experimental rats.

METHODS: The experimental laboratory was done by using 9 female of Wistar rats (Rattus novergicus) that divided into 3 groups with the age between 2.5-3 months and weight between 133-160 grams. The first group was a control given distilled water and a normal diet. The second group was given antidote 5 mL of P. macrocarpa fruit extract x BW/200 g dosage for 7 days and induced by 1000 mg/L of Cd (II) ion with dosage of 1 mL x BW/200 g. The third group was given 1000 mg/L Cd (II) ion only of 1 mL x BW/200 g. After 5 hours, the blood sample was taken for analysis of MDA, SGOT, and SGPT.

RESULTS: As the result of experimental rats exposed with Cd (II) ion, there are significant decreasing of all the observed parameters including MAD, SGOT and SGPT with percentage 71.5%, 72.1%, and 93.6% respectively.

CONCLUSION: The rats given with the antidote of Phaleria macrocarpa flesh fruit were able to protect the liver from damage due to exposure to Cd (II) as seen from the decrease in liver function enzyme parameters namely SGOT and SGPT.