Oxidative Stress in Hemodialysis Pediatric Patients

Mohamed G. Shouman; Samar Sabry; Rasha E. E. Galal; Emad Salama; Aliaa Ahmed Wahby; Eman Awadallah; Abeer Selim

doi:10.3889/oamjms.2019.859

Authors

Mohamed G. Shouman Pediatrics Department, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt
Samar Sabry Pediatrics Department, Pediatric Nephrology Unit, Cairo University, Cairo, Egypt
Rasha E. E. Galal Pediatrics Department, Pediatric Nephrology Unit, Cairo University, Cairo, Egypt
Emad Salama Pediatrics Department, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt
Aliaa Ahmed Wahby Clinical Pathology Department, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt
Eman Awadallah Clinical Pathology Department, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt
Abeer Selim Pediatrics Department, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt

DOI:

https://doi.org/10.3889/oamjms.2019.859

Keywords:

Hemodialysis, Antioxidants, Paraoxinase, Arylesterase, Superoxide dismutase, Vitamins A, C, E, Pediatric

Abstract

BACKGROUND: Oxidative stress may play a role in complications of hemodialysis patients as atherosclerosis, thrombosis, and inflammation.

AIM: The aim of the study was to evaluate the oxidative stress in hemodialysis pediatric patients through measurement of oxidative stress enzymes as paraoxanase activity (PON), arylesterase activity (ASA), superoxide dismutase (SOD) and also non-enzymatic antioxidant vitamins as vitamins A, C and E levels.

METHODS: The study included 50 hemodialysis pediatric patients with mean age 11.4 Â± 5.4 years and 30 normal children of matched sex and age as a control group. Assessment of oxidative stresses was done using ELIZA technique.

RESULTS: SOD, ASA, and vitamin C were significantly lower among hemodialysis patients in comparison to control group (p = 0.004, 0.004, > 0.001 respectively).

CONCLUSION: The study concluded that oxidative stress was common finding in hemodialysis pediatric patients which may play a role in complications encountered among these patients.