@article{Sandhiutami_Dewi_Rahma_Yang_2022, title={Potential Use of Some Indonesian Plants to Inhibits Angiotensin-converting Enzyme In Vitro}, volume={10}, url={https://oamjms.eu/index.php/mjms/article/view/10251}, DOI={10.3889/oamjms.2022.10251}, abstractNote={<div> <p class="Pa6"><strong><span lang="EN-GB">BACKGROUND: </span></strong><span lang="EN-GB">Some Indonesian plants, such as <em>Vaccinium varingiaefolium </em>Miq., <em>Plectranthus scutellarioides </em>(L.) R.Br., <em>Syzygium myrtifolium </em>Walp., and <em>Eclipta prostrata </em>(L.) L., are rich of flavonoid and anthocyanin. Flavonoid, flavan-3-ol, quercetin, anthocyanin, and tannin compounds can reduce systemic vascular resistance because they cause vasodilation and are thought to be able to influence the function of angiotensin-converting enzyme (ACE) and inhibit ACE activity, which plays an important role in the process of hypertension.</span></p> </div> <div> <p class="Pa6"><strong><span lang="EN-GB">AIM: </span></strong><span lang="EN-GB">This study aims to determine the potential of some Indonesian plants to inhibit ACE activity.</span></p> </div> <div> <p class="Pa6"><strong><span lang="EN-GB">METHODS: </span></strong><span lang="EN-GB">Testing of ACE inhibitory activity is carried out by the hippuric acid compounds formed as a result of the reaction between the substrate and the enzyme, then measured spectrophotometrically. The inhibitory and IC</span><span class="A5"><span lang="EN-GB">50 </span></span><span lang="EN-GB">values of each test sample were compared with the positive control of Captopril.</span></p> </div> <div> <p class="Pa6"><strong><span lang="EN-GB">RESULTS: </span></strong><span lang="EN-GB">The four plant extracts contained secondary metabolites, such as flavonoids, tannins, saponins, quinones, steroids, triterpenoids, and essential oils. Ethanol extract of <em>V. varingiaefolium </em>Miq., <em>P. scutellarioides </em>(L.) R.Br., <em>S. myrtifolium </em>Walp., and <em>E. prostrata </em>(L.) L. each had an IC<span class="A5"><sub>50</sub></span></span> <span lang="EN-GB">value of ACE inhibition activity of 131.4 ppm, 206. 7 ppm, 151.2 ppm, and 196.0 ppm. The IC<span class="A5"><sub>50</sub></span></span> <span lang="EN-GB">value of the Captopril with inhibition of ACE activity is 11.1 ppm.</span></p> </div> <div><strong>CONCLUSION: </strong>This study shows that some Indonesian plants have the activity to inhibit the ACE and potential antihypertensive drug candidates with ACE inhibitory activity.</div>}, number={A}, journal={Open Access Macedonian Journal of Medical Sciences}, author={Sandhiutami, Ni Made Dwi and Dewi, Rika Sari and Rahma, Fathya and Yang, Ferry}, year={2022}, month={Aug.}, pages={1571–1576} }