@article{Hasani_Idrizi_Barbullushi_2013, title={Effect of Dual Blockade of Renin-Angiotensin System on Proteinuria}, volume={1}, url={https://oamjms.eu/index.php/mjms/article/view/oamjms.2013.004}, DOI={10.3889/oamjms.2013.004}, abstractNote={<p><strong><span style="color: black; font-family: ’Arial’,’sans-serif’; font-size: 8pt;">Aim:</span></strong><tt><span style="color: black; font-family: ’Arial’,’sans-serif’; font-size: 8pt;"> Aim of the study was the evaluation of the effect of dual blockade of the renin-angiotensin system (RAS) on proteinuria. </span></tt></p><p><strong><span style="color: black; font-family: ’Arial’,’sans-serif’; font-size: 8pt;">Material and Methods:</span></strong><tt><span style="color: black; font-family: ’Arial’,’sans-serif’; font-size: 8pt;"> Sixty patients, included in the study, were treated with </span></tt><span style="color: black; font-family: ’Arial’,’sans-serif’; font-size: 8pt;">angiotensin-converting enzyme inhibitor and angiotensin receptor blocker<tt><span style="font-family: ’Arial’,’sans-serif’; mso-ansi-font-size: 8.0pt; mso-bidi-font-size: 8.0pt;"> for a period of 3 months. </span></tt></span></p><p><strong><span style="color: black; font-family: ’Arial’,’sans-serif’; font-size: 8pt;">Results:</span></strong><tt><span style="color: black; font-family: ’Arial’,’sans-serif’; font-size: 8pt;"> The dual blockade of RAS resulted with decrease of proteinuria, a slight increase of serum creatinine and was not associated with a lowering of blood pressure.</span></tt></p><p><strong><span style="color: black; font-family: ’Arial’,’sans-serif’; font-size: 8pt;">Conclusion:</span></strong><span style="color: black; font-family: ’Arial’,’sans-serif’; font-size: 8pt;"> Combined therapy with ACE-I and ARB results in a more complete blockade of the RAS than monotherapy. In proteinuric nephropathies it reduces significantly baseline proteinuria.</span></p>}, number={1}, journal={Open Access Macedonian Journal of Medical Sciences}, author={Hasani, Eqerem and Idrizi, Alma and Barbullushi, Myftar}, year={2013}, month={Dec.}, pages={18–20} }