@article{Ezzat_Ragab_El Maksoud_Abdulla_Elhosary_2013, title={Validity of Autotaxin as a Novel Diagnostic Marker for Liver Fibrosis in Egyptian Chronic HCV Patients}, volume={1}, url={https://oamjms.eu/index.php/mjms/article/view/oamjms.2013.005}, DOI={10.3889/oamjms.2013.005}, abstractNote={<span style="font-family: ’Arial’,’sans-serif’; font-size: 8pt; mso-fareast-font-family: ’Times New Roman’; mso-bidi-font-family: ’Times New Roman’; mso-fareast-language: EN-GB; mso-ansi-language: EN-GB; mso-bidi-language: AR-EG;" lang="EN-GB">We aimed to detect the validity of serum ATX as a diagnostic marker for liver fibrosis. Forty-eight males and 16 females were enrolled in the current study. Their ages ranged from 29-57 years with mean of 45.09, all were chronically HCV infected. Laboratory assessment was done for all subjects in form of complete blood picture; liver function test; lipid profile and serum detection of ATX.</span><span style="font-family: ’Arial’,’sans-serif’; font-size: 8pt; mso-fareast-font-family: ’Times New Roman’; mso-bidi-font-family: ’Times New Roman’; mso-fareast-language: EN-GB; mso-ansi-language: EN-GB; mso-bidi-language: AR-SA;" lang="EN-GB"> Patients were grouped according to the stage of fibrosis into group 1: fibrosis score 0, 1, 2, 3; group 2: fibrosis score: 4, 5, 6.</span><span style="font-family: ’Arial’,’sans-serif’; font-size: 8pt; mso-fareast-font-family: ’Times New Roman’; mso-bidi-font-family: ’Times New Roman’; mso-fareast-language: EN-GB; mso-ansi-language: EN-GB; mso-bidi-language: AR-EG;" lang="EN-GB">The mean values of ATX in all studied patients with chronic HCV infection was </span><span style="font-family: ’Arial’,’sans-serif’; font-size: 8pt; mso-fareast-font-family: ’Times New Roman’; mso-bidi-font-family: ’Times New Roman’; mso-fareast-language: EN-GB; mso-ansi-language: EN-GB; mso-bidi-language: AR-SA;" lang="EN-GB">63.02 ± 36.29 while that of healthy controls was 65.31 ± 12.24 without any significant difference.</span><span style="font-family: ’Arial’,’sans-serif’; font-size: 8pt; mso-fareast-font-family: ’Times New Roman’; mso-bidi-font-family: ’Times New Roman’; mso-fareast-language: EN-GB; mso-ansi-language: EN-GB; mso-bidi-language: AR-EG;" lang="EN-GB"> Surprisingly, mean values of ATX were higher among patients with group 1 but it did not reach the significant level. In each group of them, the differences between mean values of ATX among different grades of liver fibrosis were insignificant. It was also noticed that the mean values of ATX were higher among men than in women .It was concluded that Autotoxin might not be used as a useful diagnostic marker for liver fibrosis in Egyptian chronic HCV patients.</span>}, number={1}, journal={Open Access Macedonian Journal of Medical Sciences}, author={Ezzat, Wafaa M. and Ragab, Halla M. and El Maksoud, Nabila Abd and Abdulla, Nour A. and Elhosary, Yasser A.}, year={2013}, month={Dec.}, pages={21–26} }