@article{Farhat_Daulay_Chrestella_Asnir_Yudhistira_Susilo_2018, title={Correlation of P38 Mitogen-Activated Protein Kinase Expression to Clinical Stage in Nasopharyngeal Carcinoma}, volume={6}, url={https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.355}, DOI={10.3889/oamjms.2018.355}, abstractNote={<p><strong>BACKGROUND: </strong>Nasopharyngeal carcinoma (NPC) is uncommon and usually diagnosed at the advanced stage. A subfamily of mitogen-activated protein kinase which is called p38 mitogen-activated protein kinase (MAPK) involved in response to stress, and plays an important role in cell regulation. There is a suggestion that p38 mitogen-activated protein kinase could be a potential biomarker to determine the clinical stage of nasopharyngeal carcinoma.</p> <p><strong>AIM: </strong>The aim of this study is for observing and analysing the correlation of p38 mitogen-activated protein kinase expression in regards to nasopharyngeal carcinoma patient’s clinical stage.</p> <p><strong>METHODS: </strong>This study involved 126 nasopharyngeal carcinoma patients admitted to Haji Adam Malik General Hospital.</p> <p><strong>RESULTS: </strong>The result of this study indicates that nasopharyngeal carcinoma mostly found in the age group 41-60 years, male, non-keratinizing squamous cell carcinoma, and stage IV group. In immunohistochemistry evaluation, most of p38 mitogen-activated protein kinase overexpressed in non-keratinizing squamous cell carcinoma, T3-T4, N2-N3 and clinical stage III-IV. Spearman’s test for categorical correlation yield p-value of < 0.001.</p> <p><strong>CONCLUSION: </strong>In conclusion, there is a significant correlation between p38 mitogen-activated protein kinase expression and the clinical stage of nasopharyngeal carcinoma.</p>}, number={11}, journal={Open Access Macedonian Journal of Medical Sciences}, author={Farhat, Farhat and Daulay, Elvita Rahmi and Chrestella, Jessy and Asnir, Rizalina Arwinati and Yudhistira, Ashri and Susilo, Riko Radityatama}, year={2018}, month={Nov.}, pages={1982–1985} }