@article{Djokic_Vojvodic_Korcok_Agic_Rankovic_Djordjevic_Vojvodic_Vlaskovic-Jovicevic_Peric-Hajzler_Vojvodic_Matovic_Sijan_Wollina_Tirant_Nguyen_Fioranelli_Lotti_2019, title={The Effects of Magnesium – Melatonin - Vit B Complex Supplementation in Treatment of Insomnia}, volume={7}, url={https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.771}, DOI={10.3889/oamjms.2019.771}, abstractNote={<p>Insomnia means difficulty in falling asleep and/or stays asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The study included 60 patients diagnosed with insomnia. The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 μg vit B12, melatonin 1 mg, Extrafolate-S 600 μg) once a day 1 hour before sleep, during the 3 months. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score ≥ 6). Mean AIS score at zero points was 14,93 ± 3,778 in the study group and 14,37 ± 4,081 in the control group (p = 0,476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10,50 ± 4,21 corresponding to mild insomnia, while median AIS score in the control group was 15,13 ± 3,76 which is referred to moderate insomnia, and difference among groups was significant (p = 0,000). Our founding’s indicating that 3 months of the Magnesium- melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause.</p>}, number={18}, journal={Open Access Macedonian Journal of Medical Sciences}, author={Djokic, Gorica and Vojvodic, Petar and Korcok, Davor and Agic, Anita and Rankovic, Anica and Djordjevic, Vladan and Vojvodic, Aleksandra and Vlaskovic-Jovicevic, Tatjana and Peric-Hajzler, Zorica and Vojvodic, Jovana and Matovic, Dusica and Sijan, Goran and Wollina, Uwe and Tirant, Michael and Nguyen, Van Thuong and Fioranelli, Massimo and Lotti, Torello}, year={2019}, month={Aug.}, pages={3101–3105} }