@article{Tuleubaev_Kamyshansky_Saginova_Tashmetov_Koshanova_2021, title={A Histologic and Histomorphometric Analysis of Bone Tissue Regeneration with Perforated Bone Allograft in Rabbit Femur Defect}, volume={9}, url={https://oamjms.eu/index.php/mjms/article/view/5588}, DOI={10.3889/oamjms.2021.5588}, abstractNote={<p><strong>AIM: </strong>The aim of this study is to provide a comparative histopathological evaluation of the regeneration of bone defect filling with perforated antibiotic-impregnated bone allograft.</p> <p><strong>MATERIALS AND METHODS: </strong>Seventy-two healthy rabbits (24 rabbits in each group) were used for this study. Bone defects (3-mm diameter, 10-mm depth) were created in the femur. Human femoral head prepared according to the Marburg bone bank system was used as a bone allograft. The control group did not receive any filling. The experimental groups were as follows: Group 1 – the defects were filled with bone allografts and Group 2 – Perforated gentamycin-impregnated bone allografts. The animals were euthanized after 14, 30, and 60 days. Evaluations consisted of histology at 14-, 30-, and 60-days post-surgery.</p> <p><strong>RESULTS: </strong>A mature bone formation in the group without a bone allograft occurred after 30 days and the group with an allograft after 14 days. In the groups with an allograft, a bone marrow defect was noted as complete closure after 30 days. Histomorphometric analysis showed that in the group with an antibiotic-impregnated bone, allograft leads to increased resorption of the allograft in the intramedullary space compared to group without antibiotic.</p> <p><strong>CONCLUSION: </strong>We believe that a perforated allograft as a result of clinical trials may be obvious and economically affordable in the treatment of bone defects. The use of gentamycin-impregnated bone allografts may be of value in the prevention and treatment of bone infections.</p>}, number={A}, journal={Open Access Macedonian Journal of Medical Sciences}, author={Tuleubaev, B. E. and Kamyshansky, E. K. and Saginova, Saginova Dina and Tashmetov, E. R. and Koshanova, A. A.}, year={2021}, month={Jan.}, pages={12–18} }