@article{Indra_Lipoeto_Hardisman_Putra_Tjong_Rahman_Yusri_Bilhaq_Pratama_Risman_2022, title={The Severity of COVID-19 and its Correlation with Inflammation Biomarkers}, volume={10}, url={https://oamjms.eu/index.php/mjms/article/view/9639}, DOI={10.3889/oamjms.2022.9639}, abstractNote={<p><strong>Introduction</strong>: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov2) or Covid-19 has been spread quickly and caused 5 million deaths until February 2022. Severe symptoms of the infection may lead to death that prompt appropriate clinical diagnosis and adequate treatment going to be necessary. Covid-19 shows a severe inflammatory response which causes an imbalance in the immune response. Therefore, circulating biomarkers that can represent inflammation and immune status are potential predictors for the prognosis of COVID-19 patients. This study aims to know the role of Neutrophil-Lymphocyte Ratio (NLR), Neutrophil Monocyte Ratio (NMR), and Lymphocyte-monocyte Ratio (LMR) as inflammatory biomarkers for the severity of Covid-19.</p> <p><strong>Methodology</strong>: This study is a single-center retrospective cohort study. The sample of this study was taken by consecutive sampling with complete clinical data from 893 Covid-19 patients from Andalas University Teaching Hospital from April 2020 to September 2021. This study uses SPSS Version 25.0 for data management and analysis.</p> <p><strong>Result</strong>: Most of the degrees of Covid-19 infection were mild degrees as many as 597 people with an NLR average value of 2.07 (0.27-34.50), and NMR average value of 7.86 (3-46), an LMR average value of 3.67 (0.25-25), an ANC value of 3.990 (945-45). 14,608).  Most of the degrees of infection in patients with negative PCR results were moderate degrees as many as 70 people with a mean NLR value of 9.0694 (0.51-47.50), a mean NMR value of 18.6199 (1.15-47.50), and a mean LMR was 3.0324 (0.29-19.50), the ANC value was 9769.73 (1.088-37,219). There was a relationship between the degree of Covid-19 infection and the NLR value (p=0.144), as well as the LMR (p=0.000), NMR(p=0.000), and ANC (p=0.000). There was no relationship between the degree of infection in the negative PCR patient group and the NLR value (p=0.000), as well as the LMR (p=0.700), NMR(p=0.120), and ANC (p=0.90).</p> <p><strong>Conclusion</strong>: The severity of Covid-19 symptoms could be predicted through inflammatory biomarkers such as NLR, LMR, and NMR.</p>}, number={A}, journal={Open Access Macedonian Journal of Medical Sciences}, author={Indra, Beni and Lipoeto, Nur Indrawaty and Hardisman, Hardisman and Putra, Andani Eka and Tjong, Djong Hon and Rahman, Sukri and Yusri, Elfira and Bilhaq, Muhammad Ridho and Pratama, Yusan and Risman, Yudha}, year={2022}, month={May}, pages={911–915} }