@article{Afdal_Jamsari_Yanwirasti_Rukmono_2022, title={Relationship of Bactericidal Permeability Increasing Protein (BPI) Polymorphysm rs1341023, rs5743507, Tumor Necrosis Factor Alpha (TNF-α) rs361525, rs1800629 with Neonatal Sepsis}, volume={10}, url={https://oamjms.eu/index.php/mjms/article/view/9762}, DOI={10.3889/oamjms.2022.9762}, abstractNote={<p><strong>Background: </strong>Neonatal sepsis is a problem in the field of child health because the incidence is increasing every year and often ends in death. This study aimed to investigate the relationship between <em>TNF-α</em> and <em>BPI</em> gene polymorphisms with neonatal sepsis.</p> <p><strong>Methods: </strong>PCR and sequencing examinations were performed on 60 DNA samples consisting of 30 samples of neonatal sepsis and 30 samples of non-neoptic sepsis. Furthermore, data in the form of DNA mutation tables were statistically processed by univariate, bivariate, and multivariate analysis. It is considered meaningful if p<0.05.</p> <p><strong>Result: </strong>The results showed that <em>BPI</em> rs1341023, rs5743507 and <em>TNF-α</em> rs361525, rs1800629 only <em>BPI</em> rs1341023 and <em>TNF-α</em> rs1800629 were mutated. Of the two genes, only <em>TNF-α </em>rs1800629 had a significant association with neonatal sepsis (p<0.05).</p> <p><strong>Conclusion: </strong>This study proved that the <em>TNF-α </em>rs1800629 mutation was the most important polymorphism in the occurrence of neonatal sepsis (p<0.05).</p> <p><strong>Keywords:</strong> <em>BPI</em>,<em> </em><em>TNF-α</em>, Neonatal, Polymorphism, Sepsis</p>}, number={A}, journal={Open Access Macedonian Journal of Medical Sciences}, author={Afdal, Afdal and Jamsari, Jamsari and Yanwirasti, Yanwirasti and Rukmono, Prambudi}, year={2022}, month={May}, pages={1038–1041} }