TY - JOUR AU - Zaki, Moushira AU - Hassan, Naglaa AU - El-Bassyouni, Hala T. AU - Kamal, Sanaa AU - Basha, Walaa AU - Azmy, Osama AU - Amr, Khalda PY - 2017/06/13 Y2 - 2024/03/28 TI - Association of the Pro12Ala Polymorphism with the Metabolic Parameters in Women with Polycystic Ovary Syndrome JF - Open Access Macedonian Journal of Medical Sciences JA - Open Access Maced J Med Sci VL - 5 IS - 3 SE - A - Basic Science DO - 10.3889/oamjms.2017.088 UR - https://oamjms.eu/index.php/mjms/article/view/oamjms.2017.088 SP - 275-280 AB - <p><strong>AIM: </strong>To investigate the association of peroxisome proliferator-activated receptor gamma (<em>PPARG</em>) Pro12Ala polymorphism with polycystic ovary syndrome (PCOS) and its effect on the metabolic parameters in PCOS women.</p><p><strong>METHODS:</strong> The study used PCR to identify the presence of the <em>PPARG </em>Pro12Ala polymorphism in 100 PCOS women and 120 age-matched healthy women. All participants were subjected to anthropometry, biochemical and metabolic evaluation.</p><p><strong>RESULTS:</strong> Significant difference in the genotypes distributions of <em>PPARG </em>Pro12Ala polymorphism was observed among PCOS women and controls (p = 0.03). The frequency of the polymorphic allele Ala was significantly higher in PCOS cases than that in the controls (OR = 2.01, p = 0.01). The carries of the variant allele Ala in PCOS women showed significant higher values in body mass index (BMI), systolic and diastolic blood pressure, waist circumference, waist to hip ratio, sum of skin folds, fasting blood glucose, fasting blood insulin, HOMA-IR, fasting triglycerides, total cholesterol and low-density lipoprotein than non-carriers.</p><strong>CONCLUSION:</strong> The <em>PPARG</em> Pro12Ala polymorphism might contribute to the risk of PCOS and abnormal metabolic parameters and could be considered as a biomarker for early diagnosis and clinic prediction of metabolic complications. ER -