TY - JOUR AU - Suyasa, I Ketut AU - Lestari, Anak Agung Wiradewi AU - Setiawan, I Gusti Ngurah Yudhi AU - Mahadewa, Tjokorda Gde Bagus AU - Widyadharma, I Putu Eka PY - 2018/11/23 Y2 - 2024/03/28 TI - Elevated High-Sensitivity C-Reactive Protein And Interleukin-6 Plasma As Risk Factors For Symptomatic Lumbar Osteoarthritis In Postmenopausal Women JF - Open Access Macedonian Journal of Medical Sciences JA - Open Access Maced J Med Sci VL - 6 IS - 11 SE - B - Clinical Sciences DO - 10.3889/oamjms.2018.422 UR - https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.422 SP - 2107-2110 AB - <p><strong>AIM:</strong> To determine whether elevated high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and erythrocyte sedimentation rate (ESR), as risk factors of symptomatic lumbar osteoarthritis (OA) in estrogen deficiency postmenopausal women.</p><p><strong>METHODS:</strong> A case-control study was conducted between January and June 2017. The inclusion criteria include post-menopausal women with estrogen deficiency with low back pain. Exclusion criteria were: patients with a history of undergoing bilateral oophorectomy, taking hormonal replacement therapy or corticosteroid, malignancies, and lumbosacral spine trauma. The blood examinations were taken to measure IL-6 level by ELISA, hs-CRP level by spectrophotometry and ESR by modified Westergren method.</p><p><strong>RESULTS:</strong> A group of 44 pairs of subjects were divided equally into case and control groups showed that in estrogen deficiency postmenopausal women, an increased level of hs-CRP increased the risk for symptomatic lumbar OA (OR = 2.83, CI95% = 1.065-8.776, p = 0.034). Also, a high level of IL-6 increased the risk of symptomatic lumbar OA (OR = 2.7, CI95% = 0.991-8.320, p = 0.033). No such significant findings were found for an increased ESR level.</p><p><strong>CONCLUSION:</strong> Elevated level of plasma hs-CRP and IL-6 were concluded as risk factors for symptomatic lumbar OA in post-menopausal women.</p> ER -