TY - JOUR AU - El-Alameey, Inas R. AU - Fadl, Nevein N. AU - Abdel Hameed, Enas R. AU - Sherif, Lobna S. AU - Ahmed, Hanaa H. PY - 2015/01/22 Y2 - 2024/03/29 TI - Clinical Relevance of Transforming Growth Factor-β1, Interleukin-6 and Haptoglobin for Prediction of Obesity Complications in Prepubertal Egyptian Children JF - Open Access Macedonian Journal of Medical Sciences JA - Open Access Maced J Med Sci VL - 3 IS - 1 SE - B - Clinical Sciences DO - 10.3889/oamjms.2015.017 UR - https://oamjms.eu/index.php/mjms/article/view/oamjms.2015.017 SP - 105-110 AB - <p><strong>BACKGROUND:</strong> The rate of obesity is increasing throughout the world. Obesity in adults’ research is characterized by chronic inflammation, associated with type 2 Diabetes and cardiovascular risk. The degree to which these changes occur in childhood obesity is not fully defined.</p><p><strong>AIM:</strong> This study was designed to explore the relation between circulating levels of pro-inflammatory cytokines, and obesity.</p><p><strong>PATIENTS AND METHODS:</strong> This cross sectional case control study was carried out in 50 randomly selected pre-pubertal overweight and obese children compared with fifty apparently healthy children of matched age and sex. Serum levels of transforming growth factor-β1, interleukin-6, and haptoglobin were quantified by ELISA technique.</p><p><strong>RESULTS:</strong> ANOVA test followed by Post Hoc test showed highly significant increase in the serum levels of the transforming growth factor-β1, interleukin-6 and haptoglobin among obese children compared to overweight and healthy children respectively. The body weight, BMI and BMI z-score were significantly positively correlated with serum levels of the three pro-inflammatory cytokines. Serum levels of interleukin-6, and haptoglobin were found to be strong predictors of complications in severe obesity by linear regression analysis.</p><strong>CONCLUSIONS:</strong> Obesity is associated with chronic low-grade inflammation. High levels of interleukin-6 and haptoglobin are considered to be early biomarkers of inflammation associated with severe obesity with subsequent cardiovascular and type 2 diabetes risk. ER -