TY - JOUR AU - Arsunan, Arsin A. AU - Elisafitri, Rezki AU - Wahyu, Atjo AU - Aisyah, Aisyah PY - 2020/09/15 Y2 - 2024/03/28 TI - Prognostic Factors and Survival Rate of Childhood Acute Lymphoblastic Leukemia in Eastern Indonesia: Kaplan–Meier and Cox Regression Approach JF - Open Access Macedonian Journal of Medical Sciences JA - Open Access Maced J Med Sci VL - 8 IS - T2 SE - Public Health Disease Control DO - 10.3889/oamjms.2020.5230 UR - https://oamjms.eu/index.php/mjms/article/view/5230 SP - 204-209 AB - <p class="Pa6"><strong><span lang="EN-US">BACKGROUND: </span></strong><span lang="EN-US">Acute lymphoblastic leukemia (ALL) is one of the most common childhood hematological malignancies with an incident each year that tends to increase.</span></p><p class="Pa6"><strong><span lang="EN-US">AIM: </span></strong><span lang="EN-US">This study aims to determine the survival rate of childhood ALL in Dr. Wahidin Sudirohusodo General Hospital and the prognostic factors that influence it.</span></p><p class="Pa6"><strong><span lang="EN-US">METHODS: </span></strong><span lang="EN-US">A retrospective cohort design was conducted among childhood ALL. The samples were patients ALL diagnosed since January 1, 2014, until 31, 2017, in Dr. Wahidin Sudirohusodo General Hospital. A total of 109 patients were selected by simple random sampling. Data collected through medical records observations. Data were analyzed using Kaplan–Meier and Cox regression analysis.</span></p><p class="Pa6"><strong><span lang="EN-US">RESULTS: </span></strong><span lang="EN-US">The cumulative survival rate of childhood ALL was 26%. The prognostic factors associated with survival of childhood ALL were nutritional status (p = 0.028), leukocyte counts (p = 0.000), platelet counts (p = 0.000), and comorbidity (p = 0.000). Based on multivariate analysis with Cox regression, the most influencing prognostic factor on survival of ALL patients was comorbidity (p = 0.000, hazard ratio = 3.699 confidence interval 95% 1.945–7.033). Childhood ALL with comorbidities had a risk of death 3699 times higher than childhood ALL without comorbidities.</span></p><p><strong>CONCLUSION: </strong>Nutritional status, leukocyte counts, platelet counts, and comorbidity were prognostic factors that influence survival of childhood ALL. Comorbidity was the most influencing prognostic factor on survival of childhood ALL.</p> ER -