TY - JOUR AU - Minh, Nguyen Thi Hong AU - Hai, Le AU - Lien, Tran Thi Nga AU - Binh, Tran Cao PY - 2021/10/08 Y2 - 2024/03/29 TI - Effect of Xylitol Chewing Gum on Presence of Streptococcus mutans in Saliva JF - Open Access Macedonian Journal of Medical Sciences JA - Open Access Maced J Med Sci VL - 9 IS - D SE - Periodontology and Oral Medicine DO - 10.3889/oamjms.2021.6928 UR - https://oamjms.eu/index.php/mjms/article/view/6928 SP - 319-323 AB - <div><p class="Pa6"><strong><span lang="EN-GB">BACKGROUND: </span></strong><span lang="EN-GB">Oral disease ranks third among the most serious diseases in the world, after cancer and cardiovascular disease. Vietnamese population has suffered from various dental and oral diseases, of which the most common have been identified to be cavities and inflammation around the teeth.</span></p></div><div><p class="Pa6"><strong><span lang="EN-GB">AIM: </span></strong><span lang="EN-GB">The aim of the study was to evaluate the effectiveness of using xylitol gum on the status of <em>Strepptococus mutans </em>bacteria in saliva.</span></p></div><div><p class="Pa6"><strong><span lang="EN-GB">METHODS: </span></strong><span lang="EN-GB">The study design was an uncontrolled clinical study conducted at the Hanvinco Texture Factory (Hanoi). Two hundred and fifty-four subjects between the ages of 18 and 63 were included in the clinical trial. These subjects brushed their teeth for 2 weeks before providing a saliva sample for <em>S. mutans. </em>The 80 subjects with the highest number of salivary <em>S. mutans </em>were recruited for the further analysis (at least 10</span><sup><span lang="EN-GB">4 </span></sup><span lang="EN-GB">CFU/ml). After each clinical intervention, participant chewed Lotte xylitol gum after each meal, two capsules each time and 1 time in the evening (total 4 times/day), continuously for 4 weeks. Saliva samples were quantified for <em>S. mutans </em>by real-time PCR method.</span></p></div><div><p class="Pa6"><strong><span lang="EN-GB">RESULTS: </span></strong><span lang="EN-GB">Quantitative analysis of <em>S. mutans </em>bacteria in saliva of 254 subjects showed that 19.7% had <em>S. mutans </em>detected within 105 CFU/ml of saliva. These result shows that nearly 20% of the subjects examined have a high risk of tooth decay. After continuous use of xylitol chewing gum 4 times a day for 4 weeks by 80 subjects, it showed a decrease in the number of <em>S. mutans </em>in the saliva of participants, and the difference was statistically significant.</span></p></div><div><strong>CONCLUSIONS: </strong>The use of xylitol chewing gum taken 4 times/day is effective in reducing the number of <em>S. mutans </em>bacteria in saliva when combined with brushing your teeth.</div> ER -