TY - JOUR AU - Saad-Hussein, Amal AU - Shahy, Eman M. AU - Shaheen, Weam AU - Taha, Mona M. AU - Mahdy-Abdallah, Heba AU - Ibrahim, Khadiga S. AU - Hafez, Salwa F. AU - Fadl, Nevein N. AU - El-Shamy, Karima A. PY - 2016/04/20 Y2 - 2024/03/28 TI - Comparative Hepatotoxicity of Aflatoxin B1 among Workers Exposed to Different Organic Dust with Emphasis on Polymorphism Role of Glutathione S-Transferase Gene JF - Open Access Macedonian Journal of Medical Sciences JA - Open Access Maced J Med Sci VL - 4 IS - 2 SE - E - Public Health DO - 10.3889/oamjms.2016.051 UR - https://oamjms.eu/index.php/mjms/article/view/oamjms.2016.051 SP - 312-318 AB - <p><strong>AIM: </strong>The study aimed to investigate effects of organic dust exposure from different sources on aflatoxin B1-albumin adducts (AFB1/Alb), and role of glutathione S-transferase (GST) gene polymorphism in hepatotoxicity of (AFB1) among exposed workers. <strong></strong></p><p><strong>MATERIAL AND METHODS: </strong>Liver enzymes, AFB1/Alb, and GST polymorphism were estimated in 132 wheat flour dust and 87 woods sawmill workers, and 156 controls.</p><p><strong>RESULTS: </strong>Results revealed that AFB1/Alb and liver enzymes were significantly elevated in exposed workers compared to controls, and were significantly higher in sawmill workers compared to flour workers. AFB1/Alb in flour and sawmill workers with GSTT1 and GSTM1&amp;GSTT1 null genotypes were significantly higher than controls, and in sawmill workers with GSTM1&amp;GSTT1 null than flour workers. Liver enzymes (ALT and AST) in sawmill workers were significantly higher than flour workers and controls in all GST polymorphism; except in GSTT1 polymorphism, where these enzymes were significantly higher in the two exposed groups than controls.</p><strong>CONCLUSIONS: </strong>In conclusion, organic dust exposure may cause elevation in AFB1/Alb and liver enzymes of exposed workers, and GST gene polymorphism plays an important role in susceptibility to hepatic parenchymal cell injury; except in workers with GSTT1&amp;GSTM1 null genotype, gene susceptibility seemed to have little role and the main role was for environmental exposures. ER -