TY - JOUR AU - Sitorus, Junedi AU - Hadju, Veni AU - Jafar, Nurhaedar AU - Amiruddin, Ridwan AU - Syam, Aminuddin AU - Mahmudiono, Trias AU - Djabir, Yulia Yusrini AU - Moedjiono, Apik Indarty PY - 2022/01/08 Y2 - 2024/03/29 TI - Artocarpus altilis Extract Capsules Reduce Fasting Blood Glucose in Prediabetes JF - Open Access Macedonian Journal of Medical Sciences JA - Open Access Maced J Med Sci VL - 10 IS - A SE - Pharmacology DO - 10.3889/oamjms.2022.7793 UR - https://oamjms.eu/index.php/mjms/article/view/7793 SP - 315-320 AB - <div><p class="Pa6"><strong><span lang="EN-GB">BACKGROUND: </span></strong><span lang="EN-GB">Management of prediabetes patients is essential to reduce the increased prevalence of type 2 diabetes. Prediabetes prevention strategies have been widely carried out with traditional medicine by the community.</span></p></div><div><p class="Pa6"><strong><span lang="EN-GB">AIM: </span></strong><span lang="EN-GB">This study aims to assess the effect of Artocarpus altilis extract on reducing fasting blood glucose of the patients in Maros Regency, Indonesia.</span></p></div><div><p class="Pa6"><strong><span lang="EN-GB">METHOD: </span></strong><span lang="EN-GB">The study was a double-blind, randomized controlled trial, dividing participants into intervention groups who received <em>A. altilis </em>extract (n = 37) and the control group who received placebo (n = 37). The assessment of fasting blood glucose through screening with a simple enzymatic method. A fasting blood glucose was then validated using the spectrophotometric method. The fasting blood glucose measurement was performed again after 28 days of intervention, besides physical activity, food intake, and education of prediabetes/diabetes prevention measurements. The <em>A. altilis </em>extract was developed after the cold maceration process using a freeze dryer at −60°C. The data were analyzed using chi-square, independent t-test, t-test, and Wilcoxon test.</span></p></div><div><p class="Pa6"><strong><span lang="EN-GB">RESULTS: </span></strong><span lang="EN-GB">Most participants were female (68.0%), 40–49 years (51.9%), and stay-at-home parent (70.3%). The baseline data reports all variables were not significantly different between the two groups (p &gt; 0.005). There was a significant decline in the intervention group after the intervention (114.89 ± 6.6 vs. 98.73 ± 4.8, p &lt; 0.001) and no changes in the control group (113.62 ± 6.6 vs. 113.59 ± 6.7, p = 0.768).</span></p></div><div><strong>CONCLUSION: </strong>There is a significant reduction in fasting blood glucose in the intervention group who received <em>A. altilis </em>extract.</div> ER -