TY - JOUR AU - Umar, Salman AU - Usman, Hendrizal AU - Salsabila, Hulwa AU - Zaini, Erizal PY - 2022/04/25 Y2 - 2024/03/29 TI - Solid Dispersion of Tenoxicam – HPMC by Freeze-Drying: Solid State Properties, Dissolution Study, and Analgesic Activity in Mice JF - Open Access Macedonian Journal of Medical Sciences JA - Open Access Maced J Med Sci VL - 10 IS - A SE - Pharmacology DO - 10.3889/oamjms.2022.9553 UR - https://oamjms.eu/index.php/mjms/article/view/9553 SP - 800-806 AB - <div><p class="Pa6"><strong><span lang="EN-GB">AIM: </span></strong><span lang="EN-GB">The aim of this study was to prepare solid dispersion of tenoxicam with hydroxypropyl methylcellulose (HPMC) to improve solubility, dissolution rate, and <em>in vivo </em>analgesic activity.</span></p></div><div><p class="Pa6"><strong><span lang="EN-GB">METHODS: </span></strong><span lang="EN-GB">Solid dispersion of tenoxicam with HPMC was prepared using the freeze-drying technique in three ratios of drug to carrier (1:1, 1:2, and 2:1 w/w). The s olid-state properties of solid dispersion powders were characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier-transform infrared (FT-IR) spectroscopy, and scanning electron microscope (SEM). Solubility and dissolution rate studies were conducted in an aqueous medium. Analgesic activity was evaluated using the writhing method.</span></p></div><div><p class="Pa6"><strong><span lang="EN-GB">RESULTS: </span></strong><span lang="EN-GB">Analysis of PXRD and DSC results indicated a decreased degree of crystallinity of tenoxicam in solid dispersion powders. Solid dispersion of tenoxicam exhibited a significant improvement in solubility and dissolution rate compared to intact tenoxicam, in line to the increment on the ratio of HPMC. Analgesic activity study revealed that solid dispersion 1:2 was more effective than intact tenoxicam.</span></p></div><div><strong>CONCLUSIONS: </strong>This study concludes that the solid dispersion technique is a promising strategy to improve the solubility and dissolution rate of tenoxicam.</div> ER -