TY - JOUR AU - Kusumaningrum, Hermin Pancasakti AU - Ferniah, Rejeki Siti AU - Jannah, Siti Nur AU - Kurniawati, Mufida Budi AU - Afifah, Anis AU - Sumbodo, Yoshua Mario AU - Hanif, Salma Seftia AU - Erfianti, Tia AU - Eshananda, Yuriza PY - 2022/07/05 Y2 - 2024/03/28 TI - Relationship Between Phylogenetic of Apium and Foeniculum Plants from Central Java, Indonesia, and Their Secondary Metabolites Potency against COVID-19 Protease JF - Open Access Macedonian Journal of Medical Sciences JA - Open Access Maced J Med Sci VL - 10 IS - A SE - Genetics DO - 10.3889/oamjms.2022.9852 UR - https://oamjms.eu/index.php/mjms/article/view/9852 SP - 1234-1241 AB - <div><p class="Pa6"><strong><span lang="EN-GB">BACKGROUND: </span></strong><span lang="EN-GB">The emergence of COVID-19 in the late of 2019 resulted in the massive screening of drugs, including natural products, to support the current vaccines. Apium and Foeniculum vegetables are members of the Apiaceae family that potentially used to be natural immunosuppressant.</span></p></div><div><p class="Pa6"><strong><span lang="EN-GB">AIM: </span></strong><span lang="EN-GB">The purpose of this research is to analyze the phylogenetic position between these two plants as well as find out their secondary metabolites potency against COVID-19 main protease (Mpro) and the papain-like protease (PLpro).</span></p></div><div><p class="Pa6"><strong><span lang="EN-GB">METHODS: </span></strong><span lang="EN-GB">The phylogenetic analysis of Apium and Foeniculum from Indonesia was carried out based on internal transcribed spacer (ITS) region and the bioactive virtual screening assay was completed through AutoDock Vina software.</span></p></div><div><strong>CONCLUSION: </strong>Overall, Apium and Foeniculum have close relationships among the members of Apiaceae after maximum likelihood analysis. Furthermore, it also has 70 similar bioactive compounds that some of these potentially inhibit both of COVID-19 proteases.</div> ER -