Effects of Glucose Control on Hematological Indices in Patients with Diabetes Mellitus
DOI:
https://doi.org/10.3889/oamjms.2014.015Keywords:
Diabetes Mellitus, hemogram, insulin, oral antidiabetics.Abstract
Aim: We aimed to investigate the effects of diabetes treatment modalities on haematological parameters and leukocyte formula in patients with type 2 diabetes mellitus.
Materials and Methods: The study included 102 patients with type 2 diabetes, out of which 51 receiving insulin treatment and 51 receiving oral antidiabetics (OAD). Hemogram data of insulin and OAD treated groups were compared.
Results HbA1c levels were 11.12 ± 2.09 mg/dl in insulin group and 7.94 ± 2.1 mg/dl in OAD group p=0.001. Platelet counts were 27866.67 ± 77693 109/L before treatment and 258941.18 ± 69068.2 109/L in OAD group at six months, p: 0.015 whereas; 293011.76 ± 73711.21 109/L before treatment and 289492.86 ± 82631.49 109/L in insulin group at six months p: 0.821. Monocyte counts were 0.47 ± 0.12 109/L before the treatment and 0.57 ± 0.12 109/L in mix insulin therapy subgroup at six months, p:0.004; monocyte percentage was % 6.11 ± 1.74 before the treatment and %7.51 ± 2.57 in mix insulin subgroup at six months p:0.039; Basophiles counts were 0.1 ±  0.02 109/L before treatment and 0.09 ± 0.04 109/L in intensive insulin therapy subgroup at six months, p: 0.005; Lymphocyte and basophils counts were significantly decreased at six months insulin treatment as compared to the pretreatment values.
Conclusion: This study showed that, glucose control effects; blood indices HbA1C, basophiles, eosinophils, platelets and lymphocytes counts.Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Bosman DR, Winkler AS, Marsden JT, Macdougall IC, Watkins PJ. Anemia with erythropoietin deficiency occurs early in diabetic nephropathy. J Diabetes Care. 2001; 24:495–499. DOI: https://doi.org/10.2337/diacare.24.3.495
Hekimsoy Z, Payzinb B, Ornek T, Kandoğan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications. 2004; 18:173–176. DOI: https://doi.org/10.1016/S1056-8727(02)00282-9
Mirza S, Hossain M., Mathews C., Martinez P, Pino P, Gay JL, Rentfro A, McCormick JB, Fisher-Hoch SP. Type 2-Diabetes is Associated With Elevated Levels of TNF-alpha, IL-6 and Adiponectin and Low Levels of Leptin in a Population of Mexican American: A Cross-Sectional Study. Cytokine. 2012;57(1):136-142. DOI: https://doi.org/10.1016/j.cyto.2011.09.029
Gkrania-Klotsas E, Ye Z, Cooper AJ, Sharp SJ, Luben R, Biggs ML, Chen LK, Gokulakrishnan K, Hanefeld M, Ingelsson E, Lai WA, Lin SY, Lind L, Lohsoonthorn V, Mohan V, Muscari A, Nilsson G, Ohrvik J, Chao Qiang J, Jenny NS, Tamakoshi K, Temelkova-Kurktschiev T, Wang YY, Yajnik CS, Zoli M, Khaw KT, Forouhi NG, Wareham NJ, Langenberg C. Differential White Blood Cell Count and Type 2 Diabetes: Systematic Review and Meta-Analysis of Cross-Sectional and Prospective Studies. PLoS One. 2010; 18; 5(10). DOI: https://doi.org/10.1371/journal.pone.0013405
Satman İ, İmamoğlu Ş, Yılmaz C. TEMD, diagnosis, treatment and follow-up guide of diabetes mellitus and its complications -2011; 15-15.
Waggiallah H, Alzohairy M. The effect of oxidative stress on human red cells glutathione peroxidase, glutathione reductase level, and prevalence of anemia among diabetics. N Am J Med Sci. 2011;3(7):344-347. DOI: https://doi.org/10.4297/najms.2011.3344
Thomas MC. Anemia in diabetes: marker or mediator of microvascular disease? Nat Clin Pract Nephrol. 2007;3(1):20-30. DOI: https://doi.org/10.1038/ncpneph0378
Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fast. Singapore Med J. 2008;49(2):114-116.
Bae SH, Lee J, Roh KH, Kim J. Platelet activation in patients with diabetic retinopathy. Korean J Ophthalmol. 2003; 17:140–144. DOI: https://doi.org/10.3341/kjo.2003.17.2.140
Colwell JA, Nesto RW. The platelet in diabetes-focus on prevention of ischemic events. Diabetes Care. 2003; 26:2181–2188. DOI: https://doi.org/10.2337/diacare.26.7.2181
Ateş O, Kiki I, Bilen H. Association of Mean Platelet Volume With The Degree of Retinopathy in Patients with Diabetes Mellitus. Eur J Gen Med. 2009; 6:99–102. DOI: https://doi.org/10.29333/ejgm/82648
Chang HA, Hwang HS, Park HK. The Role of Mean Platelet Volume as a Predicting Factor of Asymptomatic Coronary Artery Disease. Korean J Fam Med. 2010; 31:600–606. DOI: https://doi.org/10.4082/kjfm.2010.31.8.600
Szeremeta M, Kemona-Chetnik I, Dymicka-Piekarska V. The relations between platelet count, mean platelet volume and HbA1C in patients with type 2 diabetes. Przegl Lek. 2009; 66(12):1049-1051.
Li S, Wang C, Zhong XW, Li HQ, Fu XQ, Ran XW. Variance of mean platelet volume in subjects with normal glucose tolerance, impaired glucose regulation and type 2 diabetic mellitus and its relationship with diabetic peripheral artery disease. Zhonghua Yi Xue Za Zhi. 2012; 31; 92(4):232-235.
Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications. 2009;23(2):89-94. DOI: https://doi.org/10.1016/j.jdiacomp.2008.01.006
Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med J. 2008;49(2):114-116.
Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, Lakasas G. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2004; 15(8):475-478. DOI: https://doi.org/10.1080/0953710042000267707
Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK, Lakshmaiah V. Mean Platelet Volume in Type 2 Diabetes Mellitus. J Lab Physicians. 2012;4(1):5-9. DOI: https://doi.org/10.4103/0974-2727.98662
Vozarova B, Weyer C, Lindsay RS, Pratley RE, Bogardus C, Tataranni PA. High white blood cell count is associated with a worsening of insülin sensitivity and predicts the development of type 2 diabetes. Diabetes. 2002; 51:455–461. DOI: https://doi.org/10.2337/diabetes.51.2.455
Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001; 286:327–334. DOI: https://doi.org/10.1001/jama.286.3.327
Pickup JC, Chusney GD, Thomas SM, Burt D. Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci. 2000; 67:291–300. DOI: https://doi.org/10.1016/S0024-3205(00)00622-6
Rytter E, Vessby B, Asgard R, Johansson C, Sjödin A, Abramsson-Zetterberg L, Möller L, Basu S. Glycaemic status in relation to oxidative stress and inflammation in well-controlled type 2 diabetes subjects. Br J Nutr. 2009; 101:1423–1426. DOI: https://doi.org/10.1017/S0007114508076204
Hu FB, Meigs JB, Li TY, Rifai N, Manson JE. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes. 2004; 53:693–700. DOI: https://doi.org/10.2337/diabetes.53.3.693
Yang RZ, Lee MJ, Hu H, Pollin TI, Ryan AS, Nicklas BJ, Snitker S, Horenstein RB, Hull K, Goldberg NH, Goldberg AP, Shuldiner AR, Fried SK, Gong DW. Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med. 2006; 3:e287 DOI: https://doi.org/10.1371/journal.pmed.0030287
Gokulakrishnan K, Deepa R, Sampathkumar R, Balasubramanyam M, Mohan V. Association of leukocyte count with varying degrees of glucose intolerance in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-26). Metab Syndr Relat Disord. 2009;7(3):205-210. DOI: https://doi.org/10.1089/met.2008.0024
Downloads
Published
How to Cite
Issue
Section
License
http://creativecommons.org/licenses/by-nc/4.0
