Interleukin-6 Expression in Patients with Frailty Syndrome

Nurmila Nurmila; Wasis Udaya; Agus Sudarso; Syakib Bakri; Haerani Rasyid; Hasyim Kasim; Tutik Hardjianti; Arifin Seweng

doi:10.3889/oamjms.2022.10414

Authors

Nurmila Nurmila Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Wasis Udaya Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Agus Sudarso Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Syakib Bakri Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Haerani Rasyid Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Hasyim Kasim Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Tutik Hardjianti Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Arifin Seweng Department of Biostatistics, Public Health Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.10414

Keywords:

Frailty, Interleukin-6, Cardiovascular health study, Elderly

Abstract

Frailty is an age-related biological syndrome characterized by a decrease in physiological capacity and stress resistance as a result of a gradual decline in the body's physiological systems. Frailty syndrome is categorized into three categories: robust / fit, pre-frail, and frail. As a crucial aspect of immunosenescence, the presence of chronic "inflamm-aging" systemic inflammation characterizes aging. Proinflammatory cytokines, such as IL-6, increased in response to a rise in molecular inflammation as people got older. The goal of this study was to investigate the levels of IL-6 in older people dependent on their frailty status.

Methods: This study used a cross-sectional design with 90 patients with frailty syndrome aged >=60 years who met the research requirements at Wahidin Sudirohusodo Hospital Makassar's Geriatric Polyclinic. The Cardiovascular Health Study (CHS) scoring system is used to assess frailty syndrome. The Anova and Kruskal-Wallis tests were used in the statistical analysis, and the results were considered significant if the p-value was less than 0.05.

Results: Males made up the majority of the participants (54.4%), while females made up the rest (45.6 percent ). The most common form of weakness is frailty (43.3 percent ). Frail people had the highest levels of interleukin-6 (31.1213.40), compared to pre-frail people (22.503.29) and robust people (18.532.04). There was a statistically significant difference. Age >=70 years (27.019.02) and age 60-69 years (24.7110.94) had higher IL-6 levels. There was a statistically significant difference. Only at the age of 60-69 years did IL-6 levels change significantly between robust, pre-frail, and frail people.

Conclusions: In subjects 60-69 years old, IL-6 levels increased in proportion to the severity of frailty. Interleukin-6 levels did not vary according to the severity of frailty status in population over the age of 70

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