Determination of the Chemical Composition and Antioxidant Activity of Artemisia vulgaris and Artemisia absinthium Growing in the Conditions of the Semey Region

Kulbanu K. Kabdulkarimova; Raushan Dinzhumanova; Rauza Olzhayeva; Aikunim A. Karimova; Saltanat Ye. Uzbekova; Ainash Orazalina; Altynai Dosbayeva; Saniya A. Lauyenova

doi:10.3889/oamjms.2022.10503

Authors

Kulbanu K. Kabdulkarimova Department of Chemistry, Faculty of Engineering and Technology, Non-Profit Limited Company “Semey University Named after Shakarim,” Semey, Kazakhstan
Raushan Dinzhumanova Department of Biochemistry and Chemical Disciplines, Semey Medical University NJSC, Semey, Kazakhstan Semey, Kazakhstan https://orcid.org/0000-0001-8730-2404
Rauza Olzhayeva Department of Biochemistry and Chemical Disciplines, Semey Medical University NJSC, Semey, Kazakhstan Semey, Kazakhstan https://orcid.org/0000-0001-5363-7679
Aikunim A. Karimova Department of Chemistry, Faculty of Engineering and Technology, Non-Profit Limited Company “Semey University Named after Shakarim,” Semey, Kazakhstan
Saltanat Ye. Uzbekova Department of Chemistry, Faculty of Engineering and Technology, Non-Profit Limited Company “Semey University Named after Shakarim,” Semey, Kazakhstan
Ainash Orazalina Department of Chemistry, Faculty of Engineering and Technology, Non-Profit Limited Company “Semey University Named after Shakarim,” Semey, Kazakhstan https://orcid.org/0000-0003-4594-0138
Altynai Dosbayeva Department of Chemistry, Faculty of Engineering and Technology, Non-Profit Limited Company “Semey University Named after Shakarim,” Semey, Kazakhstan
Saniya A. Lauyenova Department of Chemistry, Faculty of Engineering and Technology, Non-Profit Limited Company “Semey University Named after Shakarim,” Semey, Kazakhstan

DOI:

https://doi.org/10.3889/oamjms.2022.10503

Keywords:

Medicinal plants, Wormwood, Mass spectrometry, Atomic emission spectrometry, Antioxidant activity

Abstract

BACKGROUND: The action of the main biologically active substances contained in medicinal products becomes obvious in combination with the action of macro- and micro-elements that determine the natural mineral composition of the plant.

AIM: The objective of this study was comparative study of the composition of macro- and micro-elements of two representatives of the genus Artemísia L. on the example of Artemisia vulgaris and Artemisia absinthium and their antioxidant activity.

METHODS: In this work, the following stages of the study were used: Gathering and preparation of medicinal plant (MP) materials; method of sampling the test material for analysis; determination of humidity; and determination of the quantitative composition by inductively coupled plasma mass spectrometry (ICP-MS) and atomic emission spectrometry ICP (AES-ICP). Determination of antioxidant activity was carried out by photometry. The accuracy of the analysis results was checked by the method of standard additives. Each sample was accurately analyzed in accordance with the recording of the instrument methodology. The necessary operating modes of the mass spectrometer were set in accordance with the manufacturer’s recommendations. To verify the reliability (accuracy) of the analysis results of micro- and macro-elements of MP, the determination was carried out by two methods: ICP-MS with ICP and AES-ICP.

RESULTS: It has been established that the indicators of the investigated MP do not exceed the permissible values for the content of residual moisture and ash. The presence of macro- and micro-elements in both objects of the study is also shown. Quercetin was identified in A. absinthium and A. vulgaris.

CONCLUSION: The obtained results of qualitative and quantitative indicators of the content of macro- and micro-elements, such as potassium, calcium, sodium, magnesium, copper, iron, manganese, as well as an analysis of the antioxidant activity of samples of A. absinthium and A. vulgaris, allow us to conclude that the studied plants are promising as a component composition for creating preparations based on them.

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References

Zhusupova GE, Shalakhmetova TM, Murzakhmetova MK, Gadetskaya AV, Zhusupova AI. Antioxidant activity of some drugs derived from plants of Kazakhstan. Electron J Bull Novosibirsk State Pedagogical Univ. 2013;5(15):43-64.

Kukenov MK, Atalykova FM, Averina VY. Resources of medicinal plants of East Kazakhstan. Alma Ata Sci. 1984;158.

Kordali S, Rotan R, Mavi A, Cakir A, Arzu A, Yildirim A. Determination of the chemical composition and antioxidant activity of the essential oil of Artemisia dracunculus and of the antifungal and antibacterial activities of Turkish Artemisia absinthium, A. dracunculus, Artemisia santonicum, and Artemisia spicigera essential oils. J Agric Food Chem. 2005;53(24):9452-8. https://doi.org/10.1021/jf0516538 PMid:16302761 DOI: https://doi.org/10.1021/jf0516538

Mojarrab M, Delazar A, Esnaashari S, Heshmati F. Chemical composition and general toxicity of essential oils extracted from the aerial parts of Artemisia armeniaca Lam. and A. incana (L.) Druce growing in Iran. Res Pharm Sci. 2013;8(1):65-9. PMid:24459478

Ticona LA, Bermejo P, Guerra JA, Abad MJ, Beltran M, Martín R, et al. Ethanolic extract of Artemisia campestris subsp. Glutinosa (Besser) Batt. inhibits HIV-1 replication in vitro through the activity of terpenes and flavonoids on viral entry and NF-κB pathway. J Ethnopharmacol. 2020;263:113163. https://doi.org/10.1016/j.jep.2020.113163 PMid:32758575 DOI: https://doi.org/10.1016/j.jep.2020.113163

Xiao P, Liang Q, Chen Q, Liu H. Artemisinin potentiates apoptosis and triggers cell cycle arrest to attenuate malignant growth of salivary gland tumor cells. Acta Biochim Pol. 2022;69(1):177-87. https://doi.org/10.18388/abp.2020_5845 PMid:35151247 DOI: https://doi.org/10.18388/abp.2020_5845

Abu-Darwish MS, Cabral C, Gonçalves MJ, Cavaleiro C, Cruz MT, Efferth T, et al. Artemisia herba-alba essential oil from Buseirah (South Jordan): Chemical characterization and assessment of safe antifungal and anti-inflammatory doses. J Ethnopharmacol. 2015;174:153-60. https://doi.org/10.1016/j.jep.08.005 PMid:26277492 DOI: https://doi.org/10.1016/j.jep.2015.08.005

Kamarauskaite J, Baniene R, Raudone L, Vilkickyte G, Vainoriene R, Motiekaityte V, et al. Antioxidant and mitochondria-targeted activity of caffeoylquinic-acid-rich fractions of wormwood (Artemisia absinthium L.) and silver wormwood (Artemisia ludoviciana Nutt.). Antioxidant (Basel). 2021;10(9):1405. https://doi.org/10.3390/antiox10091405 PMid:34573037 DOI: https://doi.org/10.3390/antiox10091405

Dinzhumanova RT, Mussabayeva BK, Abekova RS, Kassenova NB. About quantitative determination of flavonoids in vegetative raw materials. Bull Karaganda Univ Ser Chem. 2017;3(87):101-8. DOI: https://doi.org/10.31489/2017Ch3/101-107

Vanidze MR, Kalandiya AG, Shalashvili AG. Flavonoid compounds of feijoa fruits. Chem Veg Raw Mater. 2009;3:103-8.

Markaryan AA, Abramov AA. Chromatographic study of the phenolic composition of the dry extract “Nephrofit” Vestn. Moscow University Chemistry. 2003;44(5):356-60.

Temerdashev ZA, Frolova NA, Kolychev IA. Determination of phenolic compounds in medicinal plants by reverse-phase HPLC. J Anal Chem. 2011;66(4):417-24. DOI: https://doi.org/10.1134/S1061934811040150

Ziyatdinova GK, Budnikov GK. Determination of flavonols in pharmaceuticals by voltammetry. Khim Farm J. 2005;39(10):54-6. DOI: https://doi.org/10.1007/s11094-006-0021-y

Kartsova LA, Alekseeva AV. Chromatographic and electrophoretic methods for the determination of polyphenolic compounds. J Anal Chem. 2008;63(11):1126-36. DOI: https://doi.org/10.1134/S1061934808110026

Dmitrienko VA, Kudrinskaya VA, Apyari VV. Methods for isolation, condensation and determination of quercetin. J Anal Chem. 2012;67(4):340-53. DOI: https://doi.org/10.1134/S106193481204003X

Dinzhumanova RT, Bayakhmetova BB, Kurmanova ZK, Maksutova DB, Esenamanova AB, Gazizova NM. Method for the Quantitative Determination of Flavonoids in Plant Raw Materials by the Spectrophotometric Method. RK. Patent of the Republic of Kazakhstan No. 3360. Maharashtra: Published RSE, National Institute of Intellectual Property; 2018.

Eremeeva NB, Makarova NV, Platonov IA. Antioxidant activity of black chokeberry extracts obtained in supercritical conditions. Tech Technol Food Prod. 2016;42(3):12-8.

Suleimenov EM, Tkachev AV, Adekenov SM. Essential oil from Kazakhstan Artemisia species. Chem Natl Compd. 2010;46(1):135-9. DOI: https://doi.org/10.1007/s10600-010-9548-y

Kazemi M, Zand MR, Roshanaei K, Rustaiyan A. Composition of the volatile oils of Artemisia armenica Lam. and Artemisia splendens Willd. from Iran. J Essent Oil Res. 2008;22:126-8. DOI: https://doi.org/10.1080/10412905.2010.9700280

Russian Federation. State Pharmacopoeia of the Russian Federation. 13th ed. Vol. 2. Moscow: Russian Federation; 2015. p. 1004.

Russian Federation. State Pharmacopoeia of the Russian Federation. 13th ed. Vol. 3. Moscow: Russian Federation; 2015. p. 1293.

Republic of Kazakhstan. State Pharmacopoeia of the Republic of Kazakhstan. Vol. 1. Almaty: Zhibek Zholy Publishing House; 2009. p. 585.

Republic of Kazakhstan. State Pharmacopoeia of the Republic of Kazakhstan. Vol. 2. Almaty: Zhibek Zholy Publishing House; 2009. p. 804.

Makhlayuk VP. Medicinal Plants in Folk Medicine. Vol. 544. Saratov: Privozhsky Book Publishing House; 1993.

Karandashev VK, Turanov AN, Orlova TA, Lezhnev AE, Nosenko SV, Zolotarev NI, et al. The use of inductively coupled plasma mass spectrometry in the elemental analysis of environmental objects. Fact Lab Diagn Mater. 2007;73(1):12-22.

International Organization for Standardization. ISO 17294-E Methodology. Water Quality. Application of Inductively Coupled Plasma Mass Spectrometry (MS-ISP). Part 2: Definition of 62 Elements. Geneva: International Organization for Standardization; 2016:07(31).

Kabdulkarimova K, Seilgazina C, Ibrayeva L, Kaygusuz M. Chemical analysis of filamentous algae of the Semipalatinsk region by inductively coupled plasma mass spectrometry. J Fresenius Environ Bull. 2018;27(9):5975-9.

Trineeva OV. Methods for determining the antioxidant activity of objects of plant and synthetic origin in pharmacy (review). Sci Prod J Dev Registration Med Prod. 2017;4:180-97.

Kabdulkarimova KK, Aubakirova RA, Shaykhova BK, Karimova AA. Method for Determining Antioxidant Activity of Plant. Patent of the Republic of Kazakhstan. Maharashtra: Published National Institute of Intellectual Property. No 2022/0287.2; 2022.

Maslyanaya AV. Raw materials of medicinal plants-a source of trace elements. Health and education in the XXI century. Electronic scientific and educational bulletin. 2008;1:112.

Kabdulkarimova KK, Aubakirova RA, Shaikhova BK. Patent for a Utility Model Method for Determining the Activity of Superoxide Dismutase No. 6697/05.06.2; 2021.

Barkhatova EI, Safin RG, Barkhatova NA. Determination of the level of ascorbic acid in medicinal plants and the possibility of their practical use in hypovitaminosis C. Young Sci. 2017;5(14):60-7.

Vartanyan LS, Gurevich SM. Investigation of the determination of SOD activity in animal tissues with tetranitrotetrazolic blue. Quest Med Chem. 1982;5:23-56.