Microbiological Aspects Concerning the Etiology of Acute Odontogenic Inflammatory Diseases in the Soft Tissues of the Head and Neck Region

Mariia Faustova; Oleksandr Nazarchuk; Galina Loban’; David Avetikov; Maiia Ananieva; Yuliia Chumak; Viktor Havryliev

doi:10.3889/oamjms.2022.10535

Authors

Mariia Faustova Department of Microbiology, Virology and Immunology, Poltava State Medical University, Poltava, Ukraine https://orcid.org/0000-0001-5327-6324
Oleksandr Nazarchuk Department of Microbiology, National Pyrohov Memorial Medical University, Vinnytsia, Ukraine https://orcid.org/0000-0001-7581-0938
Galina Loban’ Department of Microbiology, Virology and Immunology, Poltava State Medical University, Poltava, Ukraine
David Avetikov Department of Surgical Dentistry and Maxillofacial Surgery with Plastic and Reconstructive Surgery of Head and Neck, Poltava State Medical University, Poltava, Ukraine
Maiia Ananieva Department of Microbiology, Virology and Immunology, Poltava State Medical University, Poltava, Ukraine
Yuliia Chumak Department of Microbiology, Virology and Immunology, Poltava State Medical University, Poltava, Ukraine
Viktor Havryliev Department of Surgical Dentistry and Maxillofacial Surgery with Plastic and Reconstructive Surgery of Head and Neck, Poltava State Medical University, Poltava, Ukraine

DOI:

https://doi.org/10.3889/oamjms.2022.10535

Keywords:

Odontogenic purulent inflammatory diseases, Head and neck region, Microbiota, Antibiotics, Resistance

Abstract

Odontogenic purulent inflammatory diseases (OPID) make up about 20% of cases in the structure of general surgical pathology and are among the frequent diseases of the maxillofacial region (MFR) with a high (10-40%) mortality rate. Insufficient information about the source state of acute odontogenic inflammation of the peri-mandibular soft tissues significantly reduces the effectiveness of diagnostic measures of OPID in MFR, as evidenced by almost 50% of the diagnostic error rate.

Statistically, OPID in soft-tissue of MFR most often occur due to dissemination of pathogens of the necrotized pulp, periodontal pockets in periodontitis or pericoronitis during the difficult eruption of retained teeth. Previously, the quantitative dominance (about 70%) of Staphylococcus spp. among the microorganisms isolated from the odontogenic foci of inflammation was determined. However, in recent years, with the expansion of microbiological diagnostic capabilities, the presence of non-fermenting Gram-negative bacteria and anaerobes with a significant proportional proportion of the total microbiota of OPID in soft tissue of MFR has been increasingly indicated.

Recently, there has been a rapid acquisition of resistance of pathogens of odontogenic purulent inflammatory diseases of the maxillofacial region to various groups of antibiotics, which leads to ineffectiveness of their treatment and prompts the revision of existing protocols and treatment regimens in surgical dentistry

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Little RE, Long CM, Loehrl TA, Poetker DM. Odontogenic sinusitis: A review of the current literature. Laryngoscope Investig Otolaryngol. 2018;3(2):110-14. https://doi.org/10.1002/lio2.147 PMid:29721543 DOI: https://doi.org/10.1002/lio2.147

Bali RK, Sharma P, Gaba S, Kaur A, Ghanghas P. A review of complications of odontogenic infections. Natl J Maxillofac Surg. 2015;6(2):136-43. https://doi.org/10.4103/0975-5950.183867 PMid:27390486 DOI: https://doi.org/10.4103/0975-5950.183867

Fu B, McGowan K, Sun JH, Batstone M. Increasing frequency and severity of odontogenic infection requiring hospital admission and surgical management. Br J Oral Maxillofac Surg. 2020;58(4):409-15. https://doi.org/10.1016/j.bjoms.2020.01.011 PMid:31987682 DOI: https://doi.org/10.1016/j.bjoms.2020.01.011

Weise H, Naros A, Weise C, Reinert S, Hoefert S. Severe odontogenic infections with septic progress - a constant and increasing challenge: A retrospective analysis. BMC Oral Health. 2019;19(1):173. https://doi.org/10.1186/s12903-019-0866-6 PMid:31375095 DOI: https://doi.org/10.1186/s12903-019-0866-6

Pham Dang N, Delbet-Dupas C, Mulliez A, Devoize L, Dallel R, Barthélémy I. Five predictors affecting the prognosis of patients with severe odontogenic infections. Int J Environ Res Public Health. 2020;17(23):8917. https://doi.org/10.3390/ijerph17238917 PMid:33266250 DOI: https://doi.org/10.3390/ijerph17238917

Park J, Lee JY, Hwang DS, Kim YD, Shin SH, Kim UK, et al. A retrospective analysis of risk factors of oromaxillofacial infection in patients presenting to a hospital emergency ward. Maxillofac Plast Reconstr Surg. 2019;41(1):49. https://doi.org/10.1186/s40902-019-0238-9 PMid:31815113 DOI: https://doi.org/10.1186/s40902-019-0238-9

Avetikov DS, Bukhanchenko OP, Ivanytskyi IO, Aipert VV, Steblovskyi DV. Perspectives for applying the additional study methods for diagnostics optimization of postoperative hypertrophic scars of the head and neck. Wiad Lek. 2018;71(3 Pt 1):470-473. PMid:29783207

Anwar K, Irfan N, Arain MI, Shahnaz S. Prevalence of odontogenic infections and their risk factors among the general population of Hyderabad, Pakistan. Prof Med J. 2019;26(11):1931-6. DOI: https://doi.org/10.29309/TPMJ/2019.26.11.3295

Schorn L, Schrader F, Depprich R. Evaluation of the oral health-related quality of life in patients with odontogenic fascial space abscesses and underlying conditions-a prospective questionnaire-based study. Head Face Med. 2019;15:16. https://doi.org/10.1186/s13005-019-0201-0 PMid:31227000 DOI: https://doi.org/10.1186/s13005-019-0201-0

Smaglyuk LV, Voronkova HV, Karasiunok AY, Liakhovska AV, Solovei KO. Interdisciplinary approach to diagnostics of malocclusions (review). Wiad Lek. 2019;72(5 cz 1):918-922. PMid:31175796 DOI: https://doi.org/10.36740/WLek201905135

Nadig K, Taylor MN. Factors influencing odontogenic maxillofacial infections and the economic impact at a UK hospital. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;128(1):e36. https://doi.org/10.1016/j.oooo.2019.02.062 DOI: https://doi.org/10.1016/j.oooo.2019.02.062

Al-Naqeeb AJ, Al-Naqeeb HJ. Odontogenic infections: Etiology and management. ANB Med J. 2019;15(1):6-9. DOI: https://doi.org/10.33091/AMJ.0201512019

Read-Fuller A, Mueller A, Finn R. Maxillofacial infections. Sel Readings Oral Maxillofac Surg. 2015;23(3):1-23.

Miller CR, Von Crowns K, Willoughby V. Fatal ludwig’s angina: Cases of lethal spread of odontogenic infection. Acad Forensic Pathol. 2018;8(1):150-69. https://doi.org/10.23907/2018.011 PMid:31240032 DOI: https://doi.org/10.23907/2018.011

Jung K, Ro S, Lee S. Multiple brain abscesses treated by extraction of the maxillary molars with chronic apical lesion to remove the source of infection. Maxillofac Plast Reconstr Surg. 2019;41:25. https://doi.org/10.1186/s40902-019-0208-2 DOI: https://doi.org/10.1186/s40902-019-0208-2

Vu Viet Cuong DS Avetikov SB. Kravchenko. Modern view of the etiology and pathogenesis of odontogenic abscesses and phlegmon maxillofacial region. Visnyk Problem Biologii I Medytsyny. 2014;2(107):79-83.

Faustova MO, Ananieva MM, Basarab YO, Dobrobolska OV, Vovk IM, Loban GA. Bacterial factors of cariogenicity (literature review). Wiad Lek. 2018;71(2 Pt 2):378-82. PMid:29786589

Petrushanko TA, Chereda VV, Loban GA. Role of oral cavity colonization resistance in dental caries development. Stomatologiia (Mosk). 2013;92(1):43-5. PMid:23528401

Faustova MO, Ananieva MM, Basarab YO, Loban GA. Neutrophil bactericidal activity through the stages of placement of different dental implants depending on their chemical composition. Wiad Lek. 2017;70(5):921-4. PMid:29203742

Abdullaeva SA. Modern condition of the problem of etiology, pathogenesis and treatment of the flegmon of the lower part of the mouth and neck (Review of literature). Izvestiia OshTU. 2018;3:168-72.

Chen J, Wu X, Zhu D, Xu M, Yu Y, Yu L, et al. Microbiota in human periodontal abscess revealed by 16S rDNA sequencing. Front Microbiol. 2019;10:1723. https://doi.org/10.3389/fmicb.2019.01723 PMid:31417518 DOI: https://doi.org/10.3389/fmicb.2019.01723

Shakya N, Sharma D, Newaskar V, Agrawal D, Shrivastava S, Yadav R. Epidemiology, microbiology and antibiotic sensitivity of odontogenic space infections in central India. J Maxillofac Oral Surg. 2018;17(3):324-31. https://doi.org/10.1007/s12663-017-1014-y PMid:30034150 DOI: https://doi.org/10.1007/s12663-017-1014-y

Chandra HJ, Sripathi Rao BH, Muhammed Manzoor AP, Arun AB. Characterization and antibiotic sensitivity profile of bacteria in orofacial abscesses of odontogenic origin. J Maxillofac Oral Surg. 2017;16(4):445-52. https://doi.org/10.1007/s12663-016-0966-7 PMid:29038627 DOI: https://doi.org/10.1007/s12663-016-0966-7

Shweta, Prakash SK. Dental abscess: A microbiological review. Dent Res J (Isfahan). 2013;10(5):585-591. PMid:24348613

Sabaté Brescó M, Harris LG, Thompson K, Stanic B, Morgenstern M, O’Mahony L, et al. Pathogenic mechanisms and host interactions in Staphylococcus epidermidis device-related infection. Front Microbiol. 2017;8:1401. https://doi.org/10.3389/fmicb.2017.01401 PMid:28824556 DOI: https://doi.org/10.3389/fmicb.2017.01401

Meinen A, Reuss A, Willrich N, Feig M, Noll I, Eckmanns T, et al. Antimicrobial resistance and the spectrum of pathogens in dental and oral-maxillofacial infections in hospitals and dental practices in Germany. Front Microbiol. 2021;12:676108. https://doi.org/10.3389/fmicb.2021.676108 PMid:34149666 DOI: https://doi.org/10.3389/fmicb.2021.676108

Adamson OO, Adeyemi MO, Gbotolorun OM, Oduyebo OO, Odeniyi O, Adeyemo WL. Comparison of sensitivity of bacteria isolated in odontogenic infections to ceftriaxone and amoxicillinclavulanate. Afr Health Sci. 2019;19(3):2414-20. https://doi.org/10.4314/ahs.v19i3.15 PMid:32127812 DOI: https://doi.org/10.4314/ahs.v19i3.15

Shaprynskyi V, Nazarchuk O, Faustova M, Mitiuk B, Dmytriiev D, Dobrovanov O, et al. Some aspects of infectious complications in patients with surgical diseases. Multycentr trials. Lek Obzor 2020;69(7-8):257-60.

Böttger S, Zechel-Gran S, Schmermund D, Streckbein P, Wilbrand JF, Knitschke M, et al. Microbiome of odontogenic abscesses. Microorganisms. 2021;16;9(6):1307. https://doi.org/10.3390/microorganisms9061307 PMid:34208451 DOI: https://doi.org/10.3390/microorganisms9061307

Yuvaraj V, Alexander M, Pasupathy S. Microflora in maxillofacial infections--a changing scenario? J Oral Maxillofac Surg. 2012;70(1):119-25. https://doi.org/10.1016/j.joms.2011.02.006 PMid:21511379 DOI: https://doi.org/10.1016/j.joms.2011.02.006

Altaie AM, Saddik B, Alsaegh MA, Soliman SS, Hamoudi R, Samaranayake LP. Prevalence of unculturable bacteria in the periapical abscess: A systematic review and meta-analysis. PLoS One. 2021;16(8):e0255485. https://doi.org/10.1371/journal.pone.0255485 PMid:34351963 DOI: https://doi.org/10.1371/journal.pone.0255485

Koyuncuoglu CZ, Aydin M, Kirmizi NI, Aydin V, Aksoy M, Isli F, et al. Rational use of medicine in dentistry: Do dentists prescribe antibiotics in appropriate indications? Eur J Clin Pharmacol. 2017;73(8):1027-32. https://doi.org/10.1007/s00228-017-2258-7 PMid:28462430 DOI: https://doi.org/10.1007/s00228-017-2258-7

Okunseri C, Zheng C, Steinmetz CN, Okunseri E, Szabo A. Trends and racial/ethnic disparities in antibiotic prescribing practices of dentists in the United States. J Public Health Dent. 2018;78(2):109-17. https://doi.org/10.1111/jphd.12245 PMid:28857224 DOI: https://doi.org/10.1111/jphd.12245

Ahmadi H, Ebrahimi A, Ahmadi F. Antibiotic therapy in dentistry. Int J Dent. 2021;2021:6667624. https://doi.org/10.1155/2021/6667624 PMid:33574843 DOI: https://doi.org/10.1155/2021/6667624

Rodríguez Sánchez F, Arteagoitia I, Teughels W, Rodríguez Andrés C, Quirynen M. Antibiotic dosage prescribed in oral implant surgery: A meta-analysis of cross-sectional surveys. PLoS One. 2020;15(8):e0236981. https://doi.org/10.1371/journal.pone.0236981 PMid:32810135 DOI: https://doi.org/10.1371/journal.pone.0236981

Teoh L, Cheung MC, Dashper S, James R, McCullough MJ. Oral antibiotic for empirical management of acute dentoalveolar infections-a systematic review. Antibiotics (Basel). 2021;10(3):240. https://doi.org/10.3390/antibiotics10030240 PMid:33670844 DOI: https://doi.org/10.3390/antibiotics10030240

Plum AW, Mortelliti AJ, Walsh RE. Microbial flora and antibiotic resistance in odontogenic abscesses in Upstate New York. Ear Nose Throat J. 2018;97(1-2):E27-31. https://doi.org/10.1177/0145561318097001-207 PMid:29493728 DOI: https://doi.org/10.1177/0145561318097001-207

Katsuda R, Inubushi J, Tobata H, Eguchi T, Terada K, Kagami R, et al. Genetic homology between bacteria isolated from pulmonary abscesses or pyothorax and Bacteria from the oral cavity. Microbiol Spectr. 2022;10(1):e0097421. https://doi.org/10.1128/spectrum.00974-21 PMid:35171020 DOI: https://doi.org/10.1128/spectrum.00974-21

Kaneko A, Matsumoto T, Iwabuchi H, Sato J, Wakamura T, Kiyota H, et al. Antimicrobial susceptibility surveillance of bacterial isolates recovered in Japan from odontogenic infections in 2013. J Infect Chemother. 2020;26(9):882-9. https://doi.org/10.1016/j.jiac.2020.05.019 PMid:32591324 DOI: https://doi.org/10.1016/j.jiac.2020.05.019

Tomas ME, Mana T, Wilson BM, Nerandzic MM, Joussef-Piña S, Quiñones-Mateu M, et al. Tapering courses of oral vancomycin induce persistent disruption of the microbiota that provide colonization resistance to clostridium difficile and vancomycinresistant enterococci in mice. Antimicrob Agents Chemother. 2018;62(5):e02237-17. https://doi.org/10.1128/AAC.02237-17 PMid:29530853 DOI: https://doi.org/10.1128/AAC.02237-17

Petrushanko TA, Chereda VV, Loban GA. The relationship between colonization resistance of the oral cavity and individual -typological characteristics of personality: Dental aspects. Wiad Lek. 2017;70(4):754-7. PMid:29064800

Ananieva MM, Faustova MO, Loban GA, Avetikov DS. Microbiological aspects of chlorophyllipt extract used for prevention of candida postoperative complications. Euromediterranean Biomed J. 2018;13(39):178-80.