The Level of Individual Biochemical Constants of the Brain of in the Krushinsky-Molodkina Inbred Rat Strain against the Background of Radon Inhalation During Epilepsy

Marina Nikolaishvili; Zakaria Nanobashvili; Nodar Mitagvaria; Gvantsa Chkadua; Tea Museliani; Gogi Jikia; Irine Bilanishvili; Khatuna Dondoladze

doi:10.3889/oamjms.2022.10716

Authors

Marina Nikolaishvili Laboratory of Radiobiology, Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
Zakaria Nanobashvili Laboratory of Neuropisiology, Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
Nodar Mitagvaria Laboratory of Cerebral Circulation and Metabolism, Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
Gvantsa Chkadua Laboratory of Membranology, Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
Tea Museliani Laboratory of Radiobiology, Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia; European University, Tbilisi, Georgia
Gogi Jikia Laboratory of Radiobiology, Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
Irine Bilanishvili Laboratory of Neuropisiology, Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
Khatuna Dondoladze Laboratory of Radiobiology, Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia; European University, Tbilisi, Georgia https://orcid.org/0000-0002-1458-8912

DOI:

https://doi.org/10.3889/oamjms.2022.10716

Keywords:

Biogenic amines, Amino acids, Na/K-ATPase, Oxidative processes

Abstract

Introduction: The elucidation of the mechanism of action of radon on antioxidant processes needs further research, however, based on the results of the experiment, it can be concluded that studies on experimental animals have shown that, while inhaling Tskhaltubo water, the phenomenon of hormesis develops.

Methods: we placed 10 experimental animals (KM rats) in Radon contained mineral water spa`s sauna. Inhalation of radon-water was administered through the nose, for 10 minutes, once a day, in conditions of high humidity (about 90%) for 10 days.

Results: Hormesis regulates oxidative processes in the brain due to the activation of antioxidants expressed in a decrease in existing epileptic seizures and is expressed in the activation of Na / K-ATPase and specific glutaminergic neurons of the "attack center" of the hypothalamus but also with the activation of the entire adaptive-compensatory system.

Conclusion: Inhalation of radon contained water can be considered as a method of treatment with an anticonvulsant effect confirmed by experimental studies.

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