Risk Factors for the Development of Atrial Fibrillation in the Kazakh Patients
DOI:
https://doi.org/10.3889/oamjms.2022.10775Keywords:
Atrial fibrillation, Ethnicity, Risk factorsAbstract
BACKGROUND: Atrial fibrillation (AF) is the most common persistent heart rhythm disorder.
AIM: Assessment of clinical predictors of atrial fibrillation in the Kazakh population.
METHODS: An analytical clinical and epidemiological study of 75 patients with AF of Kazakh nationality. Descriptive analysis of medical records was carried out and the results of laboratory and instrumental research methods. Statistical analysis was carried out using the Statistica 6.0 Software package from StatSoft Inc. (USA) and MS Excel.
RESULTS: In the majority of the studied patients (86.7%), atrial fibrillation was associated with hypertension, in 49.3% of patients was diagnosed with coronary artery disease. A permanent form of atrial fibrillation was observed in 63%, in 20% AF manifested itself in the form of paroxysms, in 17% AF was persistent. AF, which arose against the background of CHF, was established in 41.3% of the patients studied by us, while a decrease in LVEF below 40% was observed in 21.3% of the examined patients. In our study, diabetes mellitus was diagnosed as a comorbid pathology in 24% of patients and diabetes mellitus correlated with permanent AF in 66.7%. Thyroid pathology was observed in 9.3% cases. CRHD as a concomitant disease occurred in 12% of cases. In 5.7% of cases, AF was registered as idiopathic (primary) without a history of cardiovascular and concomitant pathology. Smoking as a risk factor was observed in 16%, alcohol consumption, was noted by 8 patients (10.7%). In 40% of cases, patients with AF were obese, 45.3% of the patients were overweight (BMI ≥25).Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke statistics-2019 update: A report from the American heart association. Circulation. 2019;139(10):e56-528. https://doi.org/10.1161/CIR.0000000000000659 PMid:30700139 DOI: https://doi.org/10.1161/CIR.0000000000000659
Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, et al. Worldwide epidemiology of atrial fibrillation: A global burden of disease 2010 study. Circulation. 2014;129(8):837-47. https://doi.org/10.1161/CIRCULATIONAHA.113.005119 PMid:24345399 DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.005119
Kolbin AS, Mosikyan AA, Tatarsky BA. Socioeconomic burden of atrial fibrillation in Russia: Dynamics for 7 years (2010-2017). Bull Arrhythm. 2018;92:42-8. https://doi.org/10.25760/VA-2018-92-42-48
Akpanova DM, Mussagaliyeva AT, Berkinbayev SF, Ospanova DA. Prevalence and major risk factors for atrial fibrillation. J Pharm Nutr Sci. 2019;9:95-100. DOI: https://doi.org/10.29169/1927-5951.2019.09.02.6
Pistoia F, Sacco S, Tiseo C, Degan D, Ornello R, Carolei A. The epidemiology of atrial fibrillation and stroke. Cardiol Clin. 2016;34(2):255-68. https://doi.org/10.1016/j.ccl.2015.12.002 PMid:27150174 DOI: https://doi.org/10.1016/j.ccl.2015.12.002
Soloviyov OV, Lukyanova IY. Clinical conditions associated with atrial fibrillation not associated with valvular heart disease. Juvenis Scientia. 2019;7:8-13.
Korennova O. Yu, et al. Atrial fibrillation in real clinical practice: Lessons from one regional register. Difficult Patient. 2015;13(4):8-10.
Loukianov M.M., Boytsov S.A., Yakushin S.S., Martsevich S. Yu., Vorobyev A.N., Zagrebelnyy A.V., et al. Diagnostics, treatment, combined cardiovascular pathology and concomitant diseases in patients with atrial fibrillation in a real outpatient practice (according to the register of cardiovascular diseases RECVAD). Ration Pharmacother Cardiol. 2014;10(4):366-77. DOI: https://doi.org/10.20996/1819-6446-2014-10-4-366-377
Suslov AS. Assessment of the nosological affiliation of atrial fibrillation in real clinical practice. Pract Med. 2014;6(82):114-7.
Trigub AV. Clinical characteristics of patients with various forms of atrial fibrillation. Innovations Med.2017; 53:144-8.
Khayitova MD, Kultaev MS, Abdugulova G. Modern clinical aspects of atrial fibrillation. Curr Sci Res Modern World. 2017;2-3:84-90.
Kopecky SL, Gersh BJ, McGoon MD, Whisnant JP, Ilstrup DM, Frye RL, et al. The natural history of lone atrial fibrillation. A population-based study over three decades. N Engl J Med. 1987;317(11):669-74. https://doi.org/10.1056/NEJM198709103171104 PMid:3627174 DOI: https://doi.org/10.1056/NEJM198709103171104
Calkins H, Kuck KH, Brugada J, Cappato R, Camm AJ, Chen SA, et al. 2012 HRS/EHRA/ECAS Expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design: A report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation. Developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology (ESC) and the European Cardiac Arrhythmia Society (ECAS); and in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), the Asia Pacific Heart Rhythm Society (APHRS), and the Society of Thoracic Surgeons (STS). Endorsed by the governing bodies of the American college of cardiology foundation, the American heart association, the European Cardiac Arrhythmia society, the European heart rhythm association, the society of thoracic surgeons, the Asia Pacific heart rhythm society, and the heart rhythm society. Heart Rhythm 2012;4(9):632-96.e21. https://doi.org/10.1016/j.hrthm.2011.12.016 PMid:22386883 DOI: https://doi.org/10.1016/j.hrthm.2011.12.016
Fatkin D, Santiago CF, Huttner IG, Lubitz SA, Ellinor PT. Genetics of atrial fibrillation: State of the art in 2017. Heart Lung Circ. 2017;26(9):894-901. https://doi.org/10.1016/j.hlc.2017.04.008 PMid:28601532
Kuskayeva AV, Nikulina SY, Chernova AA, Aksyutina NV. Genetic predictors of atrial fibrillation. Ration Pharmacother Cardiol. 2016;12(3):331-6. https://doi.org/10.20996/1819-6446-2016-12-3-331-336 DOI: https://doi.org/10.20996/1819-6446-2016-12-3-331-336
Fatkin D, Santiago CF, Huttner IG, Lubitz SA, Ellinor PT. Genetics of atrial fibrillation: State of the art in 2017. Heart Lung Circ. 2017;26(9):894-901. https://doi.org/10.1016/j.hlc.2017.04.008 PMid:28601532 DOI: https://doi.org/10.1016/j.hlc.2017.04.008
Chalazan B, Mol D, Sridhar A, Alzahrani Z, Darbar SD, Ornelas- Loredo A, et al. Genetic modulation of atrial fibrillation risk in a Hispanic/Latino cohort. PLoS One. 2018;13(4):e0194480. https://doi.org/10.1371/journal.pone.0194480 PMid:29624624 DOI: https://doi.org/10.1371/journal.pone.0194480
Lubitz SA, Husser D. Genomic risk scores in atrial fibrillation: Predicting the unpredictable? Eur Heart J. 2013;34(29):2227-9. https://doi.org/10.1093/eurheartj/eht106 DOI: https://doi.org/10.1093/eurheartj/eht106
Alonso A, Agarwal SK, Soliman EZ, Ambrose M, Chamberlain AM, Prineas RJ, et al. Incidence of atrial fibrillation in whites and African-Americans: The atherosclerosis risk in communities (ARIC) study. Am Heart J. 2009;158(1):111-7. https://doi.org/10.1016/j.ahj.2009.05.010 PMid:19540400 DOI: https://doi.org/10.1016/j.ahj.2009.05.010
Bai Y, Wang YL, Shantsila A, Lip GY. The global burden of atrial fibrillation and stroke: A systematic review of the clinical epidemiology of atrial fibrillation in Asia. Chest. 2017;152(4):810-20. https://doi.org/10.1016/j.chest.2017.03.048 PMid:28427968 DOI: https://doi.org/10.1016/j.chest.2017.03.048
Chugh SS, Roth GA, Gillum RF, Mensah GA. Global burden of atrial fibrillation in developed and developing nations. Glob Heart. 2014;9(1):113-9. https://doi.org/10.1016/j.gheart.2014.01.004 PMid:25432121 DOI: https://doi.org/10.1016/j.gheart.2014.01.004
Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European association for cardio-thoracic surgery (EACTS): The task force for the diagnosis and management of atrial fibrillation of the European society of cardiology (ESC) developed with the special contribution of the European heart rhythm association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373-498. https://doi.org/10.1093/eurheartj/ehaa612 PMid:32860505 DOI: https://doi.org/10.1093/eurheartj/ehab648
Kurashin V.K., Borovkova N.Yu., Borovkov N.N., Kurashina V.A., Bakka T.E. Clinical and pathogenetic characteristics and management of patients with atrial fibrillation in a cardiology department at the present time. Cardiovascular Therapy and Prevention. 2020;19(3):2488. DOI: https://doi.org/10.15829/1728-8800-2020-2488
Komissarenko IA. Atrial fibrillation in elderly and senile patients. Clin Gerontol. 2020;26(1-2): 51-58.
Ciarambino T, Sansone G, Para O, Giordano M. Atrial Fibrillation: All The Elderly Go Hospitalized? A Minireview. Journal of Gerontology and Geriatrics. 2020 Mar 31;68:47-52. DOI: https://doi.org/10.36150/2499-6564-375
Koval SM, Snegurskaya IO. Risk factors for atrial fibrillation and outstanding issues of its prevention. Hypertens. 2016;49(5):61-9. https://doi.org/10.22141/2224-1485.5.49.2016.83866 DOI: https://doi.org/10.22141/2224-1485.5.49.2016.83866
Schoonderwoerd BA, Smit MD, Pen L, Van Gelder IC. New risk factors for atrial fibrillation: Causes of ‘not-so-lone atrial fibrillation’. Europace. 2008;10(6):668-73. https://doi.org/10.1093/europace/eun124 PMid:18480076 DOI: https://doi.org/10.1093/europace/eun124
Tegene E, Tadesse I, Markos Y, Gobena T. Prevalence and risk factors for atrial fibrillation and its anticoagulant requirement in adults aged ≥40 in Jimma town, Southwest Ethiopia: A community based cross-sectional study. Int J Cardiol Heart Vasc. 2019;22:199-204. https://doi.org/10.1016/j.ijcha.2019.02.003 PMid:30963095 DOI: https://doi.org/10.1016/j.ijcha.2019.02.003
Ogunsua AA, Shaikh AY, Ahmed M, McManus DD. Atrial fibrillation and hypertension: Mechanistic, epidemiologic, and treatment parallels. Methodist Debakey Cardiovasc J. 2015;11(4):228-34. https://doi.org/10.14797/mdcj-11-4-228 PMid:27057292 DOI: https://doi.org/10.14797/mdcj-11-4-228
Qureshi W, Soliman EZ, Solomon SD, Alonso A, Arking DE, Shah A, et al. Risk factors for atrial fibrillation in patients with normal versus dilated left atrium (from the atherosclerosis risk in communities study). Am J Cardiol. 2014;114(9):1368-72. https://doi.org/10.1016/j.amjcard.2014.07.073 PMid:25245413 DOI: https://doi.org/10.1016/j.amjcard.2014.07.073
Soloviev OV, Lukyanova IY. Clinical conditions associated with atrial fibrillation not associated with valvular heart disease. Juvenis Scientia. 2019;7:8-13. DOI: https://doi.org/10.32415/jscientia.2019.07.02
Tereshchenko SN, Zhirov IV, Romanova NV, Osmolovskaya Y, Golitsyn SP. The first Russian register of patients with chronic heart failure and atrial fibrillation(RIF-CHF): Study design. Ration Pharmacother Cardiology. 2015;11(6):577-81. https://doi.org/10.20996/1819-6446-2015-11-6-577-581 DOI: https://doi.org/10.20996/1819-6446-2015-11-6-577-581
Khidirova LD, Yakhontov DA, Zinin SA. Features of the course and progression of atrial fibrillation in patients with arterial hypertension and extracardial pathology. Siberian Sci Med J. 2019;39(2):86-91. https://doi.org/10.15372/SSMJ201902012 DOI: https://doi.org/10.15372/SSMJ201902012
Mont L, Guach E. Atrial fibrillation progression: How sick is the atrium? Heart Rhythm. 2017;14(6):808-9. https://doi.org/10.1016/j.hrthm.2017.02.027 PMid:28259695 DOI: https://doi.org/10.1016/j.hrthm.2017.02.027
Huxley RR, Alonso A, Lopez FL, Filion KB, Agarwal SK, Loehr LR, et al. Type 2 diabetes, glucose homeostasis and incident atrial fibrillation: The atherosclerosis risk in communities study. Heart. 2012;98(2):133-8. https://doi.org/10.1136/heartjnl-2011-300503 PMid:21930722 DOI: https://doi.org/10.1136/heartjnl-2011-300503
Huxley RR, Filion KB, Konety S, Alonso A. Meta-analysis of cohort and case-control studies of Type 2 diabetes mellitus and risk of atrial fibrillation. Am J Cardiol. 2011;108(1):56-62. https://doi.org/10.1016/j.amjcard.2011.03.004 PMid:21529739 DOI: https://doi.org/10.1016/j.amjcard.2011.03.004
Huxley RR, Lopez FL, Folsom AR, Agarwal SK, Loehr LR, Soliman EZ, et al. Absolute and attributable risks of atrial fibrillation in relation to optimal and borderline risk factors: The atherosclerosis risk in communities (ARIC) study. Circulation. 2011;123(14):1501-8. https://doi.org/10.1161/CIRCULATIONAHA.110.009035 PMid:21444879 DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.009035
Tănase DM, Ionescu SD, Ouatu A, Ambăruş V, Arsenescu- Georgescu C. Risk assessment in the development of atrial fibrillation at patients with associate thyroid dysfunctions. Rev Med Chir Soc Med Nat Iasi. 2013;117(3):623-9. PMid:24502026
Leonova EI, Shehan GG, Zadionchenko VS. Atrial fibrillation in patients with chronic obstructive pulmonary disease. Ration Pharmacother Cardiol. 2014;10(3):328-33. DOI: https://doi.org/10.20996/1819-6446-2014-10-3-328-333
Liang Y, Mente A, Yusuf S, Gao P, Sleight P, Zhu J, et al. Alcohol consumption and the risk of incident atrial fibrillation among people with cardiovascular disease. CMAJ. 2012;184(16):E857-66. https://doi.org/10.1503/cmaj.120412. PMid:23027910 DOI: https://doi.org/10.1503/cmaj.120412
Gémes K, Malmo V, Laugsand LE, Loennechen JP, Ellekjaer H, László KD, et al. Does moderate drinking increase the risk of atrial fibrillation? The Norwegian hunt (Nord-Trøndelag health) study. J Am Heart Assoc. 2017;6(10):e007094. https://doi.org/10.1161/JAHA.117.007094 PMid:29054845 DOI: https://doi.org/10.1161/JAHA.117.007094
Wang TJ, Parise H, Levy D, D’Agostino RB Sr., Wolf PA, Vasan RS, et al. Obesity and the risk of new-onset atrial fibrillation. JAMA. 2004;292(20):2471-77. https://doi.org/10.1001/jama.292.20.2471 PMid:15562125 DOI: https://doi.org/10.1001/jama.292.20.2471
Asad Z, Abbas M, Javed I, Korantzopoulos P, Stavrakis S. Obesity is associated with incident atrial fibrillation independent of gender: A meta-analysis. J Cardiovasc Electrophysiol. 2018;29(5):725-32. https://doi.org/10.1111/jce.13458 PMid:29443438 DOI: https://doi.org/10.1111/jce.13458
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2022 Dana Taizhanova, Nazira Bazarova, Akerke Kalimbetova, Tatyana Gartung, Roza Bodaubay, Shynar Muratbekova, Zhansaya Rustembekkyzy (Author)
![Creative Commons License](http://i.creativecommons.org/l/by-nc/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0