Association between the HLA-DQB1 Gene Polymorphism and Chronic Progression of Hepatitis B in Indonesia
DOI:
https://doi.org/10.3889/oamjms.2022.10818Keywords:
HLA-DQB1, Chronic hepatitis B, HLA Polymorphism, Hepatitis B progressionAbstract
BACKGROUND: The progression of hepatitis B is affected by the activity of T lymphocytes. Activation of T lymphocytes requires a primary signal originating from the presentation of antigen by HLA molecules to T cell receptors. HLA-DQB1 gene polymorphisms can affect the ability of HLA to bind and present viral antigens to T cells, thus affecting T cell activation and potentially associated with the progression of chronic hepatitis B.
AIM: We aimed to investigate the polymorphisms of the HLA-DQB1 gene and its influence on chronic hepatitis B progression of chronic hepatitis B patients in Indonesia.
METHODS: This cross-sectional research studied chronic hepatitis B patients at the Internal Medicine Department, Arifin Ahmad Hospital, Pekanbaru, from January 2018 to December 2018. Subjects were grouped into three categories: (1) Inactive chronic hepatitis B, (2) active chronic hepatitis B, and (3) end stage liver disease (ESLD) which consisted of patients with liver cirrhosis and hepatocellular carcinoma. Examination of the HLA-DQB1 gene polymorphism was performed with the SSP-PCR method and sequenced to verify the PCR results. Analysis results of p < 0.05 were considered statistically significant.
RESULTS: The most common allele in patients with chronic hepatitis B was the HLA-DQB1 0301. The HLA-DQB1 0301 allele found primarily in the inactive chronic hepatitis B group. The DQB1 0501 allele found to be more abundant in patients with active chronic hepatitis B. The HLA DQB1 0502 allele only found in patients with chronic hepatitis B with ESLD.
CONCLUSIONS: The HLA-DQB1 gene polymorphism is associated with the progression of chronic hepatitis B in chronic hepatitis B patients in Indonesia.
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Fletcher GJ, Samuel P, Christdas J, Gnanamony M, Ismail AM, Anantharam R, et al. Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population. Genes Immun. 2011;12(7):552-8. https://doi.org/10.1038/gene.2011.32 PMid:21593777 DOI: https://doi.org/10.1038/gene.2011.32
Yano Y, Seo Y, Azuma T, Hayashi Y. Hepatitis B virus and host factors. Hepatobiliary Surg Nutr. 2013;2(2):121-3. https://doi.org/10.3978/j.issn.2304-3881.2012.10.10 PMid:24570927
Klein J, Sato A. The HLA system. First of two parts. N Engl J Med. 2000;343(10):702-9. https://doi.org/10.1056/NEJM200009073431006 PMid:10974135 DOI: https://doi.org/10.1056/NEJM200009073431006
Thio CL, Carrington M, Marti D, O’Brien SJ, Vlahov D, Nelson KE, et al. Class II HLA alleles and hepatitis B virus persistence in African Americans. J Infect Dis. 1999;179(4):1004-6. https://doi.org/10.1086/314684 PMid:10068598 DOI: https://doi.org/10.1086/314684
Pita I, Horta-Vale AM, Cardoso H, Macedo G. Hepatitis B inactive carriers: An overlooked population? GE Port J Gastroenterol. 2014;21(6):241-9. DOI: https://doi.org/10.1016/j.jpge.2014.08.003
Potosek J, Curry M, Buss M, Chittenden E. Integration of palliative care in end-stage liver disease and liver transplantation. J Palliat Med. 2014;17(11):1271-7. https://doi.org/10.1089/jpm.2013.0167 PMid:25390468 DOI: https://doi.org/10.1089/jpm.2013.0167
Doganay L, Fejzullahu A, Katrinli S, Enc FY, Ozturk O, Colak Y, et al. Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B. World J Gastroenterol. 2014;20(25):8179-86. https://doi.10.3748/wjg.v20.i25.8179 PMid:25009391 DOI: https://doi.org/10.3748/wjg.v20.i25.8179
You H, Kong Y, Hou J, Wei L, Zhang Y, Niu J, et al. Female gender lost protective effect against disease progression in elderly patients with chronic hepatitis B. Sci Rep. 2016;6(1):37498. https://doi.org/10.1038/srep37498 PMid:27892487 DOI: https://doi.org/10.1038/srep37498
Karra VK, Chowdhury SJ, Ruttala R, Gumma PK, Polipalli SK, Chakravarti A, et al. HLA-DQA1 and DQB1 variants associated with hepatitis B virus-related chronic hepatitis, cirrhosis and hepatocellular carcinoma. Indian J Med Res. 2018;147(6):573-80. https://doi.org/10.4103/ijmr.IJMR_1644_15 PMid:30168489 DOI: https://doi.org/10.4103/ijmr.IJMR_1644_15
Godkin A, Davenport M, Hill AV. Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness. Hepatology. 2005;41(6):1383-90. https://doi.org/10.1002/hep.20716 PMid:15915462 DOI: https://doi.org/10.1002/hep.20716
Thursz MR, Kwiatkowski D, Allsopp CE, Greenwood BM, Thomas HC, Hill AV. Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. N Engl J Med. 1995;332(16):1065-9. https://doi.org/10.1056/NEJM199504203321604 PMid:7898524 DOI: https://doi.org/10.1056/NEJM199504203321604
Riazalhosseini B, Mohamed Z, Apalasamy YD, Eng HS, Mohamed R. Prevalence of HLA-DQ alleles and haplotypes in patients with hepatitis B infection. Am Acad Sci Res J Eng Technol Sci. 2018;43(1):159-68.
Xin YN, Lin ZH, Jiang XJ, Zhan SH, Dong QJ, Wang Q, et al. Specific HLA-DQB1 alleles associated with risk for development of hepatocellular carcinoma: A meta-analysis. World J Gastroenterol. 2011;17(17):2248-54. https://doi.org/10.3748/wjg.v17.i17.2248 PMid:21633537 DOI: https://doi.org/10.3748/wjg.v17.i17.2248
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Copyright (c) 2022 Fatmawati Fatmawati, Ellyza Nasrul, Nasrul Zubir, Jamsari Jamsari, Bastian Nova, Aulia Janer (Author)
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