Challenge in Diagnosing Osteopoikilosis: A Case Report
DOI:
https://doi.org/10.3889/oamjms.2022.10889Keywords:
Osteopoikilosis, Diagnosis, Rare bone diseaseAbstract
Background: Osteopoikilosis is a rare benign osteosclerotic dysplasia and occurs in 1/50,000 people. Osteopoikilosis is inherited in an autosomal dominant and associated with several clinical manifestations. Currently, there is no agreement on diagnosing osteopoikilosis. In this case report, we describe a 24-year-old female patient complaining of a lump and pain in the sole of the right foot.
Case presentation: A 24 years female complained of a painful lump on the right pedis for one year. On physical examination of the right foot found a painful lump with firm boundaries, no sign of inflammation or trauma, and 1 cm x 0,5 cm x 0,5 cm in size. We perform a radiographic examination including bone survey and found multiple homogenous sclerotic lesions were spread over almost all visualized bony structures with oval to round in shape, varied in size, and well-defined borders. The laboratory examination shows normal results. Based on the findings described above, we diagnosed the patient with osteopoikilosis. The patient was provided with analgesics as therapy and periodic observation.
Conclusion: Osteopoikilosis is a rare case and is generally found incidentally on radiographic examination. The combination of history taking, clinical manifestations, and typical radiographic findings is sufficient to establish the diagnosis. This can prevent unnecessary examinations or invasive procedures.
Keywords: Osteopoikilosis, diagnosis, rare bone disease
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Korkmaz MF, Elli M, Özkan MB, Bilgici MC, Dağdemir A, Korkmaz M, et al. Osteopoikilosis: Report of a familial case and review of the literature. Rheumatol Int. 2015;35(5):921-4. https://doi.org/10.1007/s00296-014-3160-6 PMid:25352085 DOI: https://doi.org/10.1007/s00296-014-3160-6
Serdaroǧlu M, Çapkin E, Üçüncü F, Tosun M. Case report of a patient with osteopoikilosis. Rheumatol Int. 2007;27(7):683-6. https://doi.org/10.1007/s00296-006-0262-9 PMid:17106662 DOI: https://doi.org/10.1007/s00296-006-0262-9
Botwin A, Wasyliw C. Osteopoikilosis demonstrating multiple joint involvement in an adult male: An incidental radiographic finding. Cureus. 2018;10(9):e3253 https://doi.org/10.7759/cureus.3253 PMid:30430046 DOI: https://doi.org/10.7759/cureus.3253
Wordsworth P, Chan M. Melorheostosis and osteopoikilosis: A review of clinical features and pathogenesis. Calcif Tissue Int. 2019;104(5):530-43. https://doi.org/10.1007/s00223-019-00543-y PMid:30989250 DOI: https://doi.org/10.1007/s00223-019-00543-y
Mahbouba J, Mondher G, Amira M, Walid M, Naceur B. Osteopoikilosis: A rare cause of bone pain. Caspian J Intern Med. 2015;6(3):177-9. PMid:26644888
Carpintero P, Abad JA, Serrano P, Serrano JA, Rodríguez P, Castro L. Clinical features of ten cases of osteopoikilosis. Clin Rheumatol. 2004;23(6):505-8. https://doi.org/10.1007/s10067-004-0935-2 PMid:15801069 DOI: https://doi.org/10.1007/s10067-004-0935-2
Paparella MT, Gangai I, Porro C, Eusebi L, Silveri F, Cammarota A, et al. Osteopoikilosis in the ribs, pelvic region and spine: A case report. Digit Diagn. 2022;2(4):481-7. https://doi.org/10.17816/dd79504 DOI: https://doi.org/10.17816/DD79504
Azarfar A, Taj H, Seifert M. Osteopoikilosis: Rare case with incidental radiographic findings. Int J Med (Dubai) 2020;8:1-3. https://doi.org/10.1136/emj.2006.045765 DOI: https://doi.org/10.14419/ijm.v8i1.30168
Küçükçakir N, İnceoğlu LA, Raıf SL. Osteopoikilosis-a case report. Department of physical medicine and rehabilitation, Uludağ university faculty of medicine, Bursa. Turk J Phys Med Rehab. 2015;61:375-9. https://doi.org/10.5152/tftrd.2015.39019 DOI: https://doi.org/10.5152/tftrd.2015.39019
Benli TT, Akalin S, Boysan E, Mumcu EF, Kis M, Turkoolu D. Epidemiological, clinical and radiological aspects of osteopoikilosis. J Bone Joint Surg Br. 1992;74(4):504-6. https://doi.org/10.1302/0301-620X.74B4.1624505 PMid:1624505 DOI: https://doi.org/10.1302/0301-620X.74B4.1624505
Ye C, Lai Q, Zhang S, Gao T, Zeng J, Dai M. Osteopoikilosis found incidentally in a 17-year-old adolescent with femoral shaft fracture: A case report. Medicine (Baltimore). 2017;96(47):e8650. https://doi.org/10.1097/MD.0000000000008650 PMid:29381938 DOI: https://doi.org/10.1097/MD.0000000000008650
Delsignore JL, Dvoretsky PM, Hicks DG, O’Keefe RJ, Rosier RN. Mastocytosis presenting as a skeletal disorder. Iowa Orthop J. 1996;16:126-34. PMid:9129284
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Copyright (c) 2022 Yuni Artha Prabowo Putro, Rahadyan Magetsari, Morteza Bahesdhi Salipi, A. Faiz Huwaidi, Paramita Ayu Saraswati (Author)
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