Correlation of Fibroblast Activation Protein Expression and Incidence of Epithelial Ovarian Cancer Recurrence

Authors

  • Effinia Kamila Hanum Siregar Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
  • Riza Rivany Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
  • Muhammad Rusda Harahap Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
  • Iman Helmi Effendi Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
  • Dudy Aldiansyah Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
  • Roy Yustin Simanjuntak Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
  • Edy Ardiansyah Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.10954

Keywords:

Epithelial ovarian cancer, Recurrence, Allred score, Fibroblast activation protein

Abstract

Background : Ovarian cancer is one of women death causes and almost diagnosed at advanced stage which related to high recurrence rate therefore accurate biomarker is needed to predict recurrence rate.

Aim: This research purpose to determine correlation of fibroblast activation protein (FAP) expression and epithelial ovarian cancer recurrence at H. Adam Malik Hospital Medan.

Methods: This research is an analytic observational study with case control approach that will be carried out starting in May 2022 until number of samples is met. Immunohistochemical assessment for FAP expression uses Allred score because this system is simplest and has good sensitivity and specificity. The preparations were interpreted by two anatomical pathologists. The correlation between variables was carried out by chi square statistical test with 95% confidence interval and p < 0.05 was considered significant.

Results: The analysis results using Chi Square test showed that there was a significant relationship between tissue FAP expression and ovarian cancer recurrence (p = 0.004). The OR value obtained was 7.429 (95% CI = 1.778 – 31.040), which means patients with tissue FAP expression (+) had risk of recurrent ovarian cancer 7.429 times greater than patients with  tissue FAP expression (-).

Conclusion : There is a statistically significant correlation between FAP expression and epithelial ovarian cancer recurrence.

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References

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Published

2022-12-21

How to Cite

1.
Siregar EKH, Rivany R, Harahap MR, Effendi IH, Aldiansyah D, Simanjuntak RY, Ardiansyah E. Correlation of Fibroblast Activation Protein Expression and Incidence of Epithelial Ovarian Cancer Recurrence. Open Access Maced J Med Sci [Internet]. 2022 Dec. 21 [cited 2024 Feb. 26];10(B):2627-31. Available from: https://oamjms.eu/index.php/mjms/article/view/10954

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Section

Gynecology and Obstetrics

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