Correlation of Fibroblast Activation Protein Expression and Incidence of Epithelial Ovarian Cancer Recurrence

Effinia Kamila Hanum Siregar; Riza Rivany; Muhammad Rusda Harahap; Iman Helmi Effendi; Dudy Aldiansyah; Roy Yustin Simanjuntak; Edy Ardiansyah

doi:10.3889/oamjms.2022.10954

Authors

Effinia Kamila Hanum Siregar Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
Riza Rivany Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
Muhammad Rusda Harahap Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
Iman Helmi Effendi Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
Dudy Aldiansyah Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
Roy Yustin Simanjuntak Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia
Edy Ardiansyah Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.10954

Keywords:

Epithelial ovarian cancer, Recurrence, Allred score, Fibroblast activation protein

Abstract

Background : Ovarian cancer is one of women death causes and almost diagnosed at advanced stage which related to high recurrence rate therefore accurate biomarker is needed to predict recurrence rate.

Aim: This research purpose to determine correlation of fibroblast activation protein (FAP) expression and epithelial ovarian cancer recurrence at H. Adam Malik Hospital Medan.

Methods: This research is an analytic observational study with case control approach that will be carried out starting in May 2022 until number of samples is met. Immunohistochemical assessment for FAP expression uses Allred score because this system is simplest and has good sensitivity and specificity. The preparations were interpreted by two anatomical pathologists. The correlation between variables was carried out by chi square statistical test with 95% confidence interval and p < 0.05 was considered significant.

Results: The analysis results using Chi Square test showed that there was a significant relationship between tissue FAP expression and ovarian cancer recurrence (p = 0.004). The OR value obtained was 7.429 (95% CI = 1.778 – 31.040), which means patients with tissue FAP expression (+) had risk of recurrent ovarian cancer 7.429 times greater than patients with tissue FAP expression (-).

Conclusion : There is a statistically significant correlation between FAP expression and epithelial ovarian cancer recurrence.

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References

Schauer IG, Sood AK, Mok S, Liu J. Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer. Neoplasia. 2011;13(5):393-405. https://doi.org/10.1593/neo.101720 PMid:21532880

Luvero D, Milani A, Ledermann JA. Treatment options in recurrent ovarian cancer: Latest evidence and clinical potential. Ther Adv Med Oncol. 2019;6(5):229-39. https://doi.org/10.1177/1758834014544121 PMid:25342990

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. https://doi.org/10.3322/caac.21492 PMid:30207593

Johari AB, Siregar FG. Insidensi Kanker Ovarium berdasarkan Faktor Risiko di RSUP Haji Adam Malik Medan Tahun 2008- 2011. E Jurnal FK USU. 2013;1(1):1-6.

Kumlasari C, Rusda M, Sidabutar E, Ardiansyah E, Simanjuntak R, Aldiansyah D. The difference between HE4 expression in urine of women with ovarian cyst and women with normal ovary. Giorn Int Ost Gin. 2018;40(4);151-7. PMid:34201616

Hennessy BT, Coleman RL, Markman M. Ovarian cancer. Lancet. 2019;374(9698):1371-82. https://doi.org/10.1016/S0140-6736(09)61338-6 PMid:19793610

Mhawech-Fauceglia P, Yan L, Sharifian M, Ren X, Liu S, Kim G, et al. Stromal expression of Fibroblast Activation Protein Alpha (FAP) predicts platinum resistance and shorter recurrence in patients with epithelial ovarian cancer. Cancer Microenviron. 2015;8(1):23-31. https://doi.org/10.1007/s12307-014-0153-7 PMid:25331442

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. https://doi.org/10.3322/caac.21660 PMid:33538338

Fitzgerald AA, Weiner LM. The role of fibroblast activation protein in health and malignancy. Cancer Metastasis Rev. 2020;39(3):783-803. https://doi.org/10.1007/s10555-020-09909-3 PMid:32601975

Tao L, Huang G, Song H, Chen Y, Chen L. Cancer associated fibroblasts: An essential role in the tumor microenvironment. Oncol Lett. 2017;14(3):2611-20. https://doi.org/10.3892/ol.2017.6497 PMid:28927027

Li M, Cheng X, Rong R, Gao Y, Tang X, Chen Y. High expression of Fibroblast Activation Protein (FAP) predicts poor outcome in high-grade serous ovarian cancer. BMC Cancer. 2020;20(1):1032. https://doi.org/10.1186/s12885-020-07541-6 PMid:33109151

Plagens-Rotman K, Chmaj-Wierzchowska K, Pięta B, Bojar I. Modifiable lifestyle factors and ovarian cancer incidence in women. Ann Agric Environ Med. 2018;25(1):36-40. https://doi.org/10.5604/12321966.1233565 PMid:29575880

Mhawech-Fauceglia P, Wang D, Samrao D, Kim G, Lawrenson K, Meneses T, et al. Clinical implications of marker expression of carcinoma-associated fibroblasts (CAFs) in patients with epithelial ovarian carcinoma after treatment with neoadjuvant chemotherapy. Cancer Microenviron. 2014;7(1):33-9. https://doi.org/10.1007/s12307-013-0140-4 PMid:24214412

Rinelda Y, Farida AF. Analisis ekspresi Fibroblast Activation Protein (FAP) terhadap faktor klinkopatologi dan respon kemoterapi pada tumor ganas epitelial ovarium. Maj Patol Indones. 2021;30(2):242-50.

Zhang Y, Tang H, Cai J, Zhang T, Guo J, Feng D, et al. Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion. Cancer Lett. 2011;303(1):47-55. https://doi.org/10.1016/j.canlet.2011.01.011 PMid:21310528

Olsen CM, Nagle CM, Whiteman DC, Ness R, Pearce CL, Pike MC, et al. Obesity and risk of ovarian cancer subtypes: Evidence from the Ovarian Cancer Association Consortium. Endocr Relat Cancer 2013;20(2):251-62. https://doi.org/10.1530/ERC-12-0395 PMid:23404857

Yang Y, Yang Y, Yang J, Zhao X, Wei X. Tumor microenvironment in ovarian cancer: Function and therapeutic strategy. Front Cell Dev Biol. 2020;8:758. https://doi.org/10.3389/fcell.2020.00758 PMid:32850861

Puré E, Blomberg R. Pro-tumorigenic roles of fibroblast activation protein in cancer: Back to the basics. Oncogene. 2018;37(32):4343-57. https://doi.org/10.1038/s41388-018-0275-3 PMid:29720723

Kuzet SE, Gaggioli C. Fibroblast activation in cancer: When seed fertilizes soil. Cell Tissue Res. 2016;365(3):607-19. https://doi.org/10.1007/s00441-016-2467-x PMid:27474009

Xing F, Saidou J, Watabe K. Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci. 2011;15:166-79. https://doi.org/10.2741/3613 PMid:20036813