Selenium Levels based on Various Menopause Complaints Assessed by Menopause-specific Quality of Life Questionnaire before and after Selenium Intervention

Authors

  • Muhammad Ramadhan Hisworo Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, RSUP H. Adam Malik, Medan, Indonesia
  • Muhammad Fidel Ganis Siregar Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, RSUP H. Adam Malik, Medan, Indonesia
  • Hotma Partogi Pasaribu Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, RSUP H. Adam Malik, Medan, Indonesia
  • Johny Marpaung Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, RSUP H. Adam Malik, Medan, Indonesia
  • Muhammad Rusda Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, RSUP H. Adam Malik, Medan, Indonesia
  • Sarah Dina Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, RSUP H. Adam Malik, Medan, Indonesia
  • Edy Ardiansyah Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, RSUP H. Adam Malik, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.10955

Keywords:

Menopausal complaints, Menopause specific quality of life questionnaire, Selenium

Abstract

BACKGROUND: Menopausal symptoms can greatly affect a woman’s personal, social, and work life. Selenium functions as a cofactor for glutathione peroxidase and helps minimize oxidative damage through cellular metabolism in postmenopausal women when estradiol production decreases, antioxidant protection is lost and therefore oxidative stress is increased.

AIM: The aim of the study was to evaluated effect of selenium supplementation on selenium levels based on menopausal complaints assessed by menopause-specific quality of life questionnaire (MENQOL).

MATERIALS AND METHODS: This research is an analytical study with quasi-experimental pre-test and post-test one group only design. The research was conducted on all postmenopausal women in Medan who were aged >51-years-old and met inclusion and exclusion criteria. The research subjects underwent blood tests to assess serum selenium levels. If data were normally distributed, dependent T test will be used, while if data were not normally distributed, Wilcoxon test will be used. The analysis results were stated to be significant with p < 0.05.

RESULTS: Mean selenium serum levels before selenium administration were 93.20 ± 17.253 μg/L which increased to 132.12 ± 19.866 μg/L after selenium administration. Comparison test results of selenium levels before and after administration found p = 0.000 (p < 0.05), which means there was a significant difference of selenium serum levels before and after selenium administration. Besides that, there were no significant scores difference in aspects of vasomotor disorders (p = 1.000 [p > 0.05]), psychosocial disorders (p = 0.090 [p > 0.05]), physical disorders (p = 0.323 [p > 0.05]), and sexual disorders (p = 0.959 [p > 0.05]) between before and after selenium administration.

CONCLUSION: Total MENQOL scores and complaints based on aspects of vasomotor, psychosocial, physical, and sexual disturbances did not show statistically significant changes after administration selenium tablets 100 mcg/day for 7 days.

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Published

2022-11-06

How to Cite

1.
Hisworo MR, Siregar MFG, Pasaribu HP, Marpaung J, Rusda M, Dina S, Ardiansyah E. Selenium Levels based on Various Menopause Complaints Assessed by Menopause-specific Quality of Life Questionnaire before and after Selenium Intervention. Open Access Maced J Med Sci [Internet]. 2022 Nov. 6 [cited 2024 Jul. 21];10(B):2470-5. Available from: https://oamjms.eu/index.php/mjms/article/view/10955

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Gynecology and Obstetrics

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