Depression in COVID-19-positive Vaccinated Patients during Isolation and its Relation to Chronic Medical Diseases in Abu Dhabi, United Arab Emirates

Authors

  • Somaya Shaheen Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt https://orcid.org/0000-0001-8622-7350
  • Shaden Adel Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt
  • Noha A. Mahfouz Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt

DOI:

https://doi.org/10.3889/oamjms.2022.11153

Keywords:

Coronavirus disease 2019 positive, Isolation, Vaccination, Depression, Chronic diseases

Abstract

BACKGROUND: Psychological disorders are common in patients who experienced coronavirus disease 2019 (COVID-19). Thus, there is a need to assess the prevalence of these disorders following vaccination, particularly in non-hospitalized cases as most COVID-19 patients do not require hospitalization. The presence of specific chronic medical disease has been displayed to increase the severity of infection and may also cause negative psychological outcomes in these patients.

AIM: This study aimed to measure the prevalence of depression in COVID-19-positive non- hospitalized vaccinated patients during isolation and to detect the difference in depression between patients with and without medical diseases within the study.

METHODS: This was a cross-sectional study of a sample of patients from Abu Dhabi. A total of 194 participants were enrolled. All of them were COVID-19 vaccinated and tested positive for COVID-19. Participants were assessed using the Patient Health Questionnaire (PHQ9).

RESULTS: Depression was present in 10.8% of COVID-19 positive vaccinated patients while 89.2% had no depression according to their PHQ9 scores. A total of 18.5% of patients with chronic medical diseases had depression while 9.6% of patients without chronic medical diseases showed depression with no statistical significant difference in prevalence of depression between these two groups.

CONCLUSION: The prevalence of depression was relatively low in this study compared to previous studies. No significant difference was found in the likelihood of developing depression between patients with and without chronic medical diseases. Further studies should be conducted to evaluate the effect of vaccines on mental health.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Siddaway AP. Multidisciplinary research priorities for the COVID-19 pandemic. Lancet Psychiatry. 2020;7(7):e42. https://doi.org/10.1016/S2215-0366(20)30249-2 PMid:32563317

Zhou J, Liu L, Xue P, Yang X, Tang X. Mental health response to the COVID-19 outbreak in China. Am J Psychiatry. 2020;177(7):574-5. https://doi.org/10.1176/appi.ajp.2020.20030304 PMid:32375540

Robinson E, Sutin AR, Daly M, Jones A. A systematic review and meta-analysis of longitudinal cohort studies comparing mental health before versus during the COVID-19 pandemic in 2020. J Affect Disord. 2022;296:567-76. https://doi.org/10.1016/j.jad.2021.09.098 PMid:34600966

Xie Y, Xu E, Al-Aly Z. Risks of mental health outcomes in people with covid-19: Cohort study. BMJ. 2022;376:e068993. https://doi.org/10.1136/bmj-2021-068993 PMid:35172971

Magnúsdóttir I, Lovik A, Unnarsdóttir AB, McCartney D, Ask H, Kõiv K, et al. Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: An observational study. Lancet Public Health. 2022;7(5):E406-16. https://doi.org/10.1016/S2468-2667(22)00042-1 PMid:35298894

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239-42. https://doi.org/10.1001/jama.2020.2648 PMid:32091533

Lechien JR, Chiesa-Estomba CM, Vaira LA, De Riu G, Cammaroto G, Chekkoury-Idrissi Y, et al. Epidemiological, otolaryngological, olfactory and gustatory outcomes according to the severity of COVID-19: A study of 2579 patients. Eur Arch Otorhinolaryngol. 2021;278(8):2851-9. https://doi.org/10.1007/s00405-020-06548-w PMid:33452919

Shoaib N, Noureen N, Munir R, Shah FA, Ishtiaq N, Jamil N, et al. COVID-19 severity: Studying the clinical and demographic risk factors for adverse outcomes. PLoS One. 2021;16(8):e0255999. https://doi.org/10.1371/journal.pone.0255999 PMid:34379690

Bennett TD, Moffitt RA, Hajagos JG, Amor B, Anand A, Bissell MM, et al. Clinical characterization and prediction of clinical severity of Sars-Cov-2 infection among US adults using data from the US national COVID cohort collaborative. JAMA Netw Open. 2021;4(7):e2116901. https://doi.org/10.1001/jamanetworkopen.2021.16901 PMid:34255046

Jeong SJ, Chung WS, Sohn Y, Hyun JH, Baek YJ, Cho Y, et al. Clinical characteristics and online mental health care of asymptomatic or mildly symptomatic patients with coronavirus disease 2019. PLoS One. 2020;15(11):e0242130. https://doi.org/10.1371/journal.pone.0242130 PMid:33226989

Chen S, Aruldass AR, Cardinal RN. Mental health outcomes after SARS-CoV-2 vaccination in the United States: A national cross-sectional study. J Affect Disord. 2022;298(Pt A):396-9. https://doi.org/10.1016/j.jad.2021.10.134 PMid:34774648

CDC. COVID-19 and Your Health. Available from: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/evidence-table.htm [Last accessed on 2021 Feb 18].

Lusida MA, Salamah S, Jonatan M, Wiyogo IO, Asyari CH, Ali ND, et al. Prevalence of and risk factors for depression, anxiety, and stress in non-hospitalized asymptomatic and mild COVID 19 patients in East Java province, Indonesia. PLoS One. 2022;17(7):e0270966. https://doi.org/10.1371/journal.pone.0270966 PMid:35797394

Kroenke K, Spitzer RL, Williams JB. The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606-13. https://doi.org/10.1046/j.1525-1497.2001.016009606.x PMid:11556941

Gilbody S, Richards D, Brealey S, Hewitt C. Screening for depression in medical settings with the patient health questionnaire (PHQ): A diagnostic meta-analysis. J Gen Intern Med. 2007;22(11):1596-602. https://doi.org/10.1007/s11606-007-0333-y PMid:17874169

Chan YH. Biostatistics 103: Qualitative data-tests of independence. Singapore Med J. 2003;44(10):498-503. PMid:15024452

Kharaba Z, Al-Azzam S, Alhusban A, Nuseir K. A look behind the scenes: COVID-19 impact on depression and perceived stress of UAE population. Middle East Curr Psychiatry. 2021;28(1):35. https://doi.org/10.1186/s43045-021-00115-7

Deng J, Zhou F, Hou W, Silver Z, Wong CY, Chang O, et al. The prevalence of depressive symptoms, anxiety symptoms and sleep disturbance in higher education students during the COVID-19 pandemic: A systematic review and meta-analysis. Psychiatry Res. 2021;301:113863. https://doi.org/10.1016/j.psychres.2021.113863 PMid:33984824

Hallas L, Hatibie A, Majumdar S, Pyarali M, Hale TY. Variation in US States’ Responses to COVID-19. 2020. Blavatnik School of Government, University of Oxford. Report No. BSG Working Paper 2020/034.

Kadali RA, Janagama R, Peruru S, Malayala SV. Side effects of BNT162B2 mRNA COVID-19 vaccine: A randomized, cross-sectional study with detailed self-report symptoms from healthcare workers. Int J Infect Dis. 2021;106:376-81. https://doi.org/10.1016/J.ijid.2021.04.047 PMid:33866000

Yesilkaya UH, Sen M, Tasdemir BG. A novel adverse effect of the BNT162b2 mRNA vaccine: First episode of acute mania with psychotic features. Brain Behav Immun Health. 2021;18:100363. https://doi.org/10.1016/j.bbih.2021.100363 PMid:34632429

Uvais NA. Depression following ChAdOx1-S/nCoV-19 vaccine. Eur J Psychiatry 2021;36(2):140-1. https://doi.org/10.1016/j.ejpsy.2021.08.001 PMid:34608345

Guo X, Jiang K. Is depression the result of immune system abnormalities? Shanghai Arch Psychiatry. 2017;29(3):171-3. https://doi.org/10.11919/j.issn.1002-0829.217015 PMid:28904512

Sharpley AL, Cooper CM, Williams C, Godlewska BR, Cowen PJ. Effects of typhoid vaccine on inflammation and sleep in healthy participants: A double-blind, placebo-controlled, crossover study. Psychopharmacology (Berl). 2016;233(18):3429-35. https://doi.org/10.1007/s00213-016-4381-z PMid:27503474

Kuhlman KR, Robles TF, Dooley LN, Boyle CC, Haydon MD, Bower JE. Within-subject associations between inflammation and features of depression: Using the flu vaccine as a mild inflammatory stimulus. Brain Behav Immun. 2018;69:540-7. https://doi.org/10.1016/j.bbi.2018.02.001 PMid:29458196

Geriatric Medicine Research collaborative, Covid Collaborative, Welch C. Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: Results of an international multi-centre study. Age Ageing. 2021;50(3):617-30. https://doi.org/10.1093/ageing/afab026 PMid:33543243

Fisher KA, Bloomstone SJ, Walder J, Crawford S, Fouayzi H, Mazor KM. Attitudes toward a potential SARS-CoV-2 vaccine: A survey of US Adults. Ann Intern Med. 2020;173(12):964-73. https://doi.org/10.7326/M20-3569 PMid:32886525

Wu F, Lin W, Liu P, Zhang M, Huang S, Chen C, et al. Prevalence and contributory factors of anxiety and depression among pregnant women in the post-pandemic era of COVID-19 in Shenzhen, China. J Affect Disord. 2021;291:243-51. https://doi.org/10.1016/j.jad.2021.05.014 PMid:34051531

Holingue C, Badillo-Goicoechea E, Riehm KE, Veldhuis CB, Thrul J, Johnson RM, et al. Mental distress during the COVID-19 pandemic among U.S. Adults without a pre-existing mental health condition: Findings from American trend panel survey. Prev Med. 2020;139:106231. https://doi.org/10.1016/j.ypmed.2020.106231 PMid:32758507

Khubchandani J, Sharma S, Price JH, Wiblishauser MJ, Sharma M, Webb FJ. COVID-19 vaccination hesitancy in the United States: A rapid national assessment. J Community Health. 2021;46(2):270-7. https://doi.org/10.1007/s10900-020-00958-x PMid:33389421

Hause AM, Gee J, Johnson T, Jazwa A, Marquez P, Su J, et al. Anxiety-related adverse event clusters after Janssen COVID-19 vaccination-five U.S. Mass vaccination sites, April 2021. MMWR Morb Mortal Wkly Rep. 2021;70(18):685-8. https://doi.org/10.15585/mmwr.mm7018e3 PMid:33956781

Hotez P, Batista C, Ergonul O, Figueroa JP, Gilbert S, Gursel M, et al. Correcting COVID-19 vaccine misinformation: Lancet commission on COVID-19 vaccines and therapeutics task force members. EClinicalMedicine. 2021;33:100780. https://doi.org/10.1016/j.eclinm.2021.100780 PMid:33718854

Calati R, Ferrari C, Brittner M, Oasi O, Olie ́ E, Carvalho AF, et al. Suicidal thoughts and behaviors and social isolation: A narrative review of the literature. J Affect Disord. 2019;245:653-7. https://doi.org/10.1016/j.jad.2018.11.022 PMid:30445391

Erzen E, Çikrikci Ö. The effect of loneliness on depression: A meta-analysis. Int J Soc Psychiatry. 2018;64(5):427-35. https://doi.org/10.1177/0020764018776349 PMid:29792097

Budu MO, Rugel EJ, Nocos R, Teo K, Rangarajan S, Lear SA. Psychological impact of COVID-19 on people with pre-existing chronic disease. Int J Environ Res Public Health. 2021;18(11):5972. https://doi.org/10.3390/ijerph18115972

Louvardi M, Pelekasis P, Chrousos GP, Darviri C. Mental health in chronic disease patients during the COVID-19 quarantine in Greece. Palliat Support Care. 2020;18(4):394-9. https://doi.org/10.1017/S1478951520000280 PMid:32594950

Gualano MR, Lo Moro G, Voglino G, Bert F, Siliquini R. Effects of Covid-19 lockdown on mental health and sleep disturbances in Italy. Int J Environ Res Public Health. 2020;17(13):4779. https://doi.org/10.3390/ijerph17134779 PMid:32630821

Özdin S, Özdin ŞB. Levels and predictors of anxiety, depression and health anxiety during COVID-19 pandemic in Turkish society: The importance of gender. Int J Soc Psychiatry. 2020;66(5):504-11. https://doi.org/10.1177/0020764020927051 PMid:32380879

Feter N, Caputo EL, Doring IR, Leite JS, Cassuriaga J, Reichert FF, et al. Sharp increase in depression and anxiety among Brazilian adults during the COVID-19 pandemic: Findings from the PAMPA cohort. Public Health. 2021;190:101-7. https://doi.org/10.1016/j.puhe.2020.11.013 PMid:33387848

Smith L, Jacob L, Yakkundi A, McDermott D, Armstrong NC, Barnett Y, et al. Correlates of symptoms of anxiety and depression and mental wellbeing associated with COVID-19: A cross-sectional study of UK-based respondents. Psychiatry Res. 2020;291:113138. https://doi.org/10.1016/j.psychres.2020.113138 PMid:32562931

Voinov B, Richie WD, Bailey RK. Depression and chronic diseases: It is time for a synergistic mental health and primary care approach. Prim Care Companion CNS Disord. 2013;15(2):PCC.12r01468. https://doi.org/10.4088/PCC.12r01468 PMid:23930236

Blume J, Douglas SD, Evans DL. Immune suppression and immune activation in depression. Brain Behav Immun. 2011;25(2):221-9. https://doi.org/10.1016/j.bbi.2010.10.008 PMid:20955778

Downloads

Published

2022-12-19

How to Cite

1.
Shaheen S, Adel S, Mahfouz NA. Depression in COVID-19-positive Vaccinated Patients during Isolation and its Relation to Chronic Medical Diseases in Abu Dhabi, United Arab Emirates. Open Access Maced J Med Sci [Internet]. 2022 Dec. 19 [cited 2024 Apr. 19];10(B):2609-14. Available from: https://oamjms.eu/index.php/mjms/article/view/11153