Association between Vitamin D Levels and Mortality in Sepsis Patients Admitted to an Intensive Care at General Hospital Dr. M. Djamil, West Sumatera, Indonesia

Liliriawati Ananta Kahar; Yusrawati Yusrawati; Jamsari Jamsari; Tinni Maskoen

doi:10.3889/oamjms.2023.11162

Authors

Liliriawati Ananta Kahar Department of Anesthesiology and Intensive Care, Faculty of Medicine, Andalas University, M. Djamil Hospital, Padang, Indonesia https://orcid.org/0000-0001-6679-9036
Yusrawati Yusrawati Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Padang, Indonesia
Jamsari Jamsari Department of Biotechnology, Postgraduate Program, Andalas University, Padang, Indonesia
Tinni Maskoen Faculty of Medicine, Padjajaran University, Bandung, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2023.11162

Keywords:

Vitamin D, Deficiency, Sepsis, Mortality, Intensive care

Abstract

BACKGROUND: Vitamin D deficiency is associated with an increased risk and progression of the disease, especially sepsis. Low serum Vitamin D levels when patients enter the Intensive Care Unit (ICU) can affect patient care outcomes.

AIM: This study aims to determine the relationship between Vitamin D levels and sepsis patients’ treatment outcomes in the Intensive Care Unit.

METHODS: We analyzed 80 sepsis patients admitted from July 2022 to September 2022. This study used a cohort design. Sampling and collection were carried out from July 2022 to September 2022 in the Intensive Care Unit of Dr. M. Djamil Hospital, Padang. This study was conducted on 40 case samples and 40 control samples. The relationship between Vitamin D levels and treatment outcomes for sepsis patients was analyzed using the Chi-Square/Fisher Exact Test.

RESULTS: Patients with the most Vitamin D deficiency were women (77.5%), obese (57.5%), with the most comorbid Chronic Kidney Injury (12.5%), the mean APACHE II score was 21, and SOFA score of 7. Patients with non-deficiency Vitamin D most was male (7%), obese (52.5%), with the most comorbid Cardiovascular Disease (15.0%), the mean APACHE II score was 19, and SOFA score of 5. In 40 patients with Vitamin D deficiency, 24 patients (57.1%) non-survived, and 16 patients (42.1%) survived (RR = 1.833).

CONCLUSION: Vitamin D deficiency increases the risk of death in septic patients, so further intervention is needed.

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