COVID-19 during the Third Semester of Pregnancy: Maternal Characteristic, Possibility of Intrauterine Transmission and Neonatal Outcome in Aceh, Indonesia

Cut Meurah Yeni; Zinatul Hayati; Sarjani M. Ali; Hasanuddin Hasanuddin; Rusnaidi Rusnaidi; Cut Rika Maharani

doi:10.3889/oamjms.2023.11196

Authors

Cut Meurah Yeni Department of Obstetrics and Gynaecology, Faculty of Medicine, Syiah Kuala University, Dr. Zainoel Abidin General Hospital, Aceh Province, Indonesia https://orcid.org/0000-0002-6010-9791
Zinatul Hayati Department of the Clinical Microbiology Section, Faculty of Medicine, Syiah Kuala University, Dr. Zainoel Abidin General Hospital, Aceh Province, Indonesia https://orcid.org/0000-0003-3775-0422
Sarjani M. Ali Department of Obstetrics and Gynaecology, Faculty of Medicine, Syiah Kuala University, Dr. Zainoel Abidin General Hospital, Aceh Province, Indonesia
Hasanuddin Hasanuddin Department of Obstetrics and Gynaecology, Faculty of Medicine, Syiah Kuala University, Dr. Zainoel Abidin General Hospital, Aceh Province, Indonesia
Rusnaidi Rusnaidi Department of Obstetrics and Gynaecology, Faculty of Medicine, Syiah Kuala University, Dr. Zainoel Abidin General Hospital, Aceh Province, Indonesia https://orcid.org/0000-0001-8675-832X
Cut Rika Maharani Department of Obstetrics and Gynaecology, Faculty of Medicine, Syiah Kuala University, Dr. Zainoel Abidin General Hospital, Aceh Province, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2023.11196

Keywords:

Anti-SAR-CoV-2 antibody, COVID-19, Pregnancy, Vertical infection

Abstract

Background: Pregnant women are vulnerable against COVID-19 infection due to physiological and immunological changes. COVID-19 in pregnancy affects fetal well-being with a potential for vertical infection.

Materials and Method: This study aims to determine the incidence of vertical infection and anti-SARS-CoV-2 antibodies in infants born to mothers with positive COVID-19 infection. Amniotic fluid, swabs of the newborn's nasopharynx and oropharynx, and swabs of the placenta were examined using RT-PCR for SARS-CoV-2. Serological examination was performed by Electro-Chemiluminescence Immunoassay (ECLIA) on infant’s blood.

Result: Four of 33 pregnant women gave birth to infants positive SARS-CoV-2 infection. RT-PCR examination of all amniotic fluid and placental swabs were negative for SARS-CoV-2. Four of 33 infants (12.1%) showed negative PCR results but positive SARS-CoV-2 antibodies, another 4 newborns (12.1%) showed positive PCR results, but no SARS-CoV-2 antibodies detected. The remaining 25 babies (75.8%) showed both negative PCR and serologic results. Conclusion: No evidence of vertical transmission found in this study.

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References

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