The Clinical Use of Genomic Profiling for Prognosis Prediction in High Grade Serous Ovarian Cancer

I Nyoman Bayu Mahendra; Fransiskus Rendy; Pande Prayudi

doi:10.3889/oamjms.2023.11199

Authors

I Nyoman Bayu Mahendra Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Faculty of Medicine, Udayana University, Prof. dr. I Gusti Ngoerah Gde Ngoerah General Hospital, Denpasar, Bali, Indonesia https://orcid.org/0000-0001-9336-8186
Fransiskus Rendy Department of Obstetrics and Gynecology, Faculty of Medicine, Udayana University, Prof. dr. I Gusti Ngoerah Gde Ngoerah General Hospital, Denpasar, Bali, Indonesia https://orcid.org/0000-0002-6412-6687
Pande Prayudi Department of Obstetrics and Gynecology, Faculty of Medicine, Udayana University, Prof. dr. I Gusti Ngoerah Gde Ngoerah General Hospital, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2023.11199

Keywords:

Epithelial ovarian carcinoma, Genetic profiles, Prognosis

Abstract

The majority of ovarian cancer cases are high-grade serous ovarian cancers (HGSOC). HGOSC harbors several genomic alterations that play crucial roles in carcinogenesis. Studies on the molecular characterization of HGSOC have suggested that HGSOC is a heterogenous disease, rather than a singular disease entity. Genomic profiling using gene expressions, methylation patterns, and non-coding RNA expression patterns have all been used as the basis for the molecular categorization of HGSOC. Understanding these classifications in relationship to the prognosis, such as overall survival, progression-free survival, and response to chemotherapy, is crucial in the age of precision medicine in order to direct specialized or targeted treatment and improve the prognosis. Research in the future will concentrate on creating therapies targeted at certain molecular subtypes.

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