COVID-19-induced Acute Coronary Syndrome: A Review of 77 Cases

Mohmmed Alharbi; Osama Alnizari; Hadi Aldarwish; Abdulmalik Alhamazani; Abdulmajeed Alsadun

doi:10.3889/oamjms.2023.11203

Authors

Mohmmed Alharbi Department of Medicine, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia
Osama Alnizari Department of Medicine, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia https://orcid.org/0000-0003-3802-3489
Hadi Aldarwish Department of Medicine, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia https://orcid.org/0000-0002-8792-8412
Abdulmalik Alhamazani Department of Medicine, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia https://orcid.org/0000-0001-9877-1126
Abdulmajeed Alsadun Department of Medicine, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia

DOI:

https://doi.org/10.3889/oamjms.2023.11203

Keywords:

Coronavirus, Ischemic heart disease, COVID-19, Acute coronary syndrome

Abstract

Abstract:

BACKGROUND: Existing research related to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which caused the COVID-19 pandemic has found that this was not only a respiratory disease. Instead, it can impact other organs such as the heart, and increase disease severity.

AIM: This study aims to review ACS cases which result from COVID-19, to improve comprehension of the presentation, clinical features, diagnostic process, and outcomes of this rare but potentially severe complication.

METODS: In this review, case report studies confirmed Acute Coronary Syndrome (ACS), and a reported diagnosis of COVID-19 was included. A literature research was performed on PubMed, Web of Science, and Scopus. However, only 77 cases met the inclusion criteria.

RESULTS: Regarding the clinical features of COVID-19 infection, the symptoms patients most frequently presented with were shortness of breath (SOB), fatigue, fever, and cough. Regarding vessels impacted by COVID-19, it was found that the right coronary artery (RCA) was the most involved vessel.

CONCLUSION: The cases with ACS frequently displayed typical symptoms of fever, chest pain, SOB, and a cough. However, This review shows that no association was found between ACS and the COVID-19 pandemic.

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References

Majumder J, Minko T. Recent developments on therapeutic and diagnostic approaches for COVID-19. AAPS J. 2021;23(1):14. https://doi.org/10.1208/s12248-020-00532-2 PMid:33400058 DOI: https://doi.org/10.1208/s12248-020-00532-2

Wolff D, Nee S, Hickey NS, Marschollek M. Risk factors for Covid-19 severity and fatality: A structured literature review. Infection. 2021;49(1):15-28. https://doi.org/10.1007/s15010-020-01509-1 PMid:32860214 DOI: https://doi.org/10.1007/s15010-020-01509-1

Mahenthiran AK, Mahenthiran AK, Mahenthiran J. Cardiovascular system and COVID-19: Manifestations and therapeutics. Rev Cardiovasc Med. 2020;21(3):399-409. https://doi.org/10.31083/j.rcm.2020.03.124 PMid:33070544 DOI: https://doi.org/10.31083/j.rcm.2020.03.124

Dou Q, Wei X, Zhou K, Yang S, Jia P. Cardiovascular manifestations and mechanisms in patients with COVID-19. Trends Endocrinol Metab. 2020;31(12):893-904. https://doi.org/10.1016/j.tem.2020.10.001 PMid:33172748 DOI: https://doi.org/10.1016/j.tem.2020.10.001

Piazza G, Campia U, Hurwitz S, Snyder JE, Rizzo SM, Pfeferman MB, et al. Registry of arterial and venous thromboembolic complications in patients with COVID-19. J Am Coll Cardiol. 2020;76(18):2060-72. https://doi.org/10.1016/j.jacc.2020.08.070 PMid:33121712 DOI: https://doi.org/10.1016/j.jacc.2020.08.070

Clerkin KJ, Fried JA, Raikhelkar J, Sayer G, Griffin JM, Masoumi A, et al. COVID-19 and cardiovascular disease. Circulation. 2020;141(20):1648-55. https://doi.org/10.1161/CIRCULATIONAHA.120.046941 PMid:32200663 DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.046941

Corrales-Medina VF, Madjid M, Musher DM. Role of acute infection in triggering acute coronary syndromes. Lancet Infect Dis. 2010;10(2):83-92. https://doi.org/10.1016/S1473-3099(09)70331-7 PMid:20113977 DOI: https://doi.org/10.1016/S1473-3099(09)70331-7

Murad MH, Sultan S, Haffar S, Bazerbachi F. Methodological quality and synthesis of case series and case reports. BMJ Evid Based Med. 2018;23(2):60-3. https://doi.org/10.1136/bmjebm-2017-110853 PMid:29420178 DOI: https://doi.org/10.1136/bmjebm-2017-110853

Braunwald E, Morrow DA. Unstable angina: Is it time for a requiem? Circulation. 2013;127(24):2452-7. https://doi.org/10.1161/CIRCULATIONAHA.113.001258 PMid:23775194 DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.001258

Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5(7):802-10. https://doi.org/10.1001/jamacardio.2020.0950 PMid:32211816 DOI: https://doi.org/10.1001/jamacardio.2020.0950

Lippi G, Franchini M, Cervellin G. Diagnosis and management of ischemic heart disease. Semin Thromb Hemost. 2013;39(2):202-13. https://doi.org/10.1055/s-0032-1333543 PMid:33881681 DOI: https://doi.org/10.1055/s-0032-1333543

Veronese G, Ammirati E, Cipriani M, Frigerio M. Fulminant myocarditis: Characteristics, treatment, and outcomes. Anatol J Cardiol. 2018;19(4):279-86. https://doi.org/10.14744/AnatolJCardiol.2017.8170 PMid:29537977 DOI: https://doi.org/10.14744/AnatolJCardiol.2017.8170

Ho JS, Tambyah PA, Ho AF, Chan MY, Sia CH. Effect of coronavirus infection on the human heart: A scoping review. Eur J Prev Cardiol. 2020;27(11):1136-48. https://doi.org/10.1177/2047487320925965 PMid:32423250 DOI: https://doi.org/10.1177/2047487320925965

Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V, et al. Inflammation, immunity, and infection in atherothrombosis: JACC review topic of the week. J Am Coll Cardiol. 2018;72(17):2071-81. https://doi.org/10.1016/j.jacc.2018.08.1043 PMid:30336831 DOI: https://doi.org/10.1016/j.jacc.2018.08.1043

Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17(5):259-60. https://doi.org/10.1038/s41569-020-0360-5 PMid:32139904 DOI: https://doi.org/10.1038/s41569-020-0360-5

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. https://doi.org/10.1001/jama.2020.1585 PMid:32031570 DOI: https://doi.org/10.1001/jama.2020.1585

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. https://doi.org/10.1016/S0140-6736(20)30183-5 PMid:31986264 DOI: https://doi.org/10.1016/S0140-6736(20)30183-5

Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: Retrospective study. BMJ. 2020;368:m1091. https://doi.org/10.1136/bmj.m1091 PMid:32217556 DOI: https://doi.org/10.1136/bmj.m1091

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395(10229):1054-62. https://doi.org/10.1016/S0140-6736(20)30566-3 PMid:32171076 DOI: https://doi.org/10.1016/S0140-6736(20)30566-3

Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, et al. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020;5(7):811-8. https://doi.org/10.1001/jamacardio.2020.1017 PMid:32219356 DOI: https://doi.org/10.1001/jamacardio.2020.1017

Hall M, Dondo TB, Yan AT, Mamas MA, Timmis AD, Deanfield JE, et al. Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort. PLoS Med. 2018;15(3):e1002501. https://doi.org/10.1371/journal.pmed.1002501 PMid:29509764 DOI: https://doi.org/10.1371/journal.pmed.1002501

Anderson JL, Morrow DA. Acute myocardial infarction. N Engl J Med. 2017;376(21):2053-64. https://doi.org/10.1056/NEJMra1606915 PMid:28538121 DOI: https://doi.org/10.1056/NEJMra1606915

Danchin N, Popovic B, Puymirat E, Goldstein P, Belle L, Cayla G, et al. Five-year outcomes following timely primary percutaneous intervention, late primary percutaneous intervention, or a pharmaco-invasive strategy in ST-segment elevation myocardial infarction: The FAST-MI programme. Eur Heart J. 2020;41(7):858-66. https://doi.org/10.1093/eurheartj/ehz665 PMid:31539043 DOI: https://doi.org/10.1093/eurheartj/ehz665

Chapman AR, Bularga A, Mills NL. High-sensitivity cardiac troponin can be an ally in the fight against COVID-19. Circulation. 2020;141(22):1733-5. https://doi.org/10.1161/CIRCULATIONAHA.120.047008 PMid:32251612 DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.047008

Borba MG, Val FF, Sampaio VS, Alexandre MA, Melo GC, Brito M, et al. Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: A randomized clinical trial. JAMA Netw Open. 2020;3(4):e208857. https://doi.org/10.1001/jamanetworkopen.2020.8857 PMid:32330277 DOI: https://doi.org/10.1001/jamanetworkopen.2020.8857

Azevedo RB, Botelho BG, Hollanda JV, Ferreira LV, Junqueira de Andrade LZ, Oei S, et al. COVID-19 and the cardiovascular system: A comprehensive review. J Hum Hypertens. 2020;35(1):4-11. https://doi.org/10.1038/s41371-020-0387-4 PMid:32719447 DOI: https://doi.org/10.1038/s41371-020-0387-4

Nfor T, Kostopoulos L, Hashim H, Jan MF, Gupta A, Bajwa T, et al. Identifying false-positive ST-elevation myocardial infarction in emergency department patients. J Emerg Med. 2012;43(4):561-7. https://doi.org/10.1016/j.jemermed.2011.09.027 PMid:22284976 DOI: https://doi.org/10.1016/j.jemermed.2011.09.027

Warner MJ, Tivakaran VS. Inferior Myocardial Infarction. Treasure Island (FL): StatPearls Publishing; 2022.

Parikh NI, Honeycutt EF, Roe MT, Neely M, Rosenthal EJ, Mittleman MA, et al. Left and codominant coronary artery circulations are associated with higher in-hospital mortality among patients undergoing percutaneous coronary intervention for acute coronary syndromes: Report from the National Cardiovascular Database Cath Percutaneous Coronary Intervention (CathPCI) Registry. Circ Cardiovasc Qual Outcomes. 2012;5(6):775-82. https://doi.org/10.1161/CIRCOUTCOMES.111.964593 PMid:23110791 DOI: https://doi.org/10.1161/CIRCOUTCOMES.111.964593