Effectiveness of Marine Bioactive Compound Fucoidan in Stimulating Osteoblast Cells Formation: A Systematic Review

Nurlindah Hamrun; Daranisa Wulan  Purnamasari; Andi Sitti Hajrah  Yusuf; Muhammad  Ruslin

doi:10.3889/oamjms.2023.11210

Authors

Nurlindah Hamrun Department of Oral Biology, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia
Daranisa Wulan Purnamasari Department of Oral Biology, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia
Andi Sitti Hajrah Yusuf Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia https://orcid.org/0000-0003-3010-4524
Muhammad Ruslin Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2023.11210

Keywords:

fucoidan, brown seaweed, osteoblast, tissue engineering, alveolar bone

Abstract

BACKGROUND: Bone loss in the oral cavity can occur in various situations, including periodontitis-related issues and complications after tooth extraction. A damaged or lost alveolar bone can be restored through a tissue engineering approach. Fucoidan, a marine biopolymer derived from brown algae, is one biomaterial that aids bone regeneration since it contains biomaterials that can generate new osteoblast cells.

AIM: The purpose of this review is to determine whether fucoidan can be employed to promote osteoblast cell growth during bone repair.

METHODS: The search strategy was performed in PubMed; Elsevier (Scopus); ScienceDirect; Libgen, and Google Scholar. In addition, a manual hand searching was performed to locate and identify additional studies.

RESULTS: Based on the reviewed articles, it has been discovered that five met the inclusion criteria and found that the marine bioactive compound fucoidan can significantly increase the expression of ALP activity.

CONCLUSION: Fucoidan is considered to have biological properties, including antithrombotic, anticoagulant, and antioxidant. It also serves as a phenotypic marker during the early stages of osteoblastic differentiation.

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