Cinnamomum burmannii Bl. Bark Ameliorate Lipid Profile and Platelet Aggregation in Dyslipidemia Mice through Antioxidant Activity

Ni Made Dwi Sandhiutami; Rika Sari  Dewi; Lilis  Suryani; Adriani  Hendra; Kevin  Christopher

doi:10.3889/oamjms.2023.11221

Authors

Ni Made Dwi Sandhiutami Departement Pharmacology, Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia https://orcid.org/0000-0003-3449-1998
Rika Sari Dewi Departement Pharmacology, Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia https://orcid.org/0000-0001-5317-4547
Lilis Suryani Departement Pharmacology, Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia
Adriani Hendra Departement Pharmacology, Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia https://orcid.org/0000-0003-0446-6695
Kevin Christopher Departement Pharmacology, Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2023.11221

Keywords:

cinnamon bark extract, Cinnamomum burmannii Bl., antioxidant, anti-platelet aggregation, anti-dyslipidemia

Abstract

BACKGROUND: Cinnamomum burmannii Bl. has a higher coumarin, flavonoids, saponins, and alkaloids.

AIM: We investigated the antioxidant, anti-platelet aggregation, and anti-dyslipidemia activity of cinnamon bark extract (CBE) in dyslipidemia mice.

METHODS: Mice were divided randomly into six groups (n = 5) that consist of normal control, negative control, positive control (atorvastatin), and test groups of CBE at doses 300, 400, and 500 mg/kg BW. All groups except normal control were given dyslipidemic-induced feed for 14 days. After that, the induction of dyslipidemia was stopped, then continued with suspension of atorvastatin (positive control) and the test group was given CBE for 7 days. Then, it was measured malondialdehyde (MDA), superoxide dismutase (SOD), bleeding time, coagulation time, total cholesterol, triglyceride, low density lipoprotein (LDL), and high-density lipoprotein (HDL).

RESULTS: The CBE has antioxidant activity by decreased MDA concentrations and increased SOD activity in dose group 300; 400; and 500 mg/kg BW compared to negative control. The anti-platelet aggregation of CBE showed that the effects of prolong bleeding time and coagulation time and improve the decreased plasma absorbance after the addition of ADP. There was a decrease in total cholesterol for the three dose groups, respectively, 20.14%, 24.42%, and 35.76%. Triglyceride levels decreased by 4.09%, 8.74%, and 12.5%. LDL levels decreased by 38.17%, 53.8%, and 67.96%. HDL levels increased by 27.29%, 67.8%, and 72.64%.

CONCLUSION: CBE has antioxidant, anti-platelet aggregation and anti-dyslipidemia activity, and potential to prevent cardiovascular disease.

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