Determination of Factors Affecting Vitamin D Levels in Women at Risk Using Classification and Regression Tree Analysis

Authors

DOI:

https://doi.org/10.3889/oamjms.2023.11340

Keywords:

Vitamin D, Premenopausal and menopausal women, Indoor working women health, Classification and regression trees, Data mining

Abstract

BACKGROUND: The influence of the factors on Vitamin D as a health indicator in premenopausal and menopausal women is a significant subject to be investigated.

AIM: The study uses the potential of classification and regression trees (CART) as a data mining method for medical type samples.

METHODS: The data set is built by records of 84 indoor working women at the age of 45 to 67 years from five Bulgarian companies. The data are obtained through laboratory tests of serum concentrations of 25-OH-Vitamin D and a questionnaire, created for the study. Statistical data processing is made by descriptive statistics and the CART method.

RESULTS: The results show Vitamin D deficiency in 69% of the studied women at risk from Stara Zagora. For the target variable – Vitamin D (the quantity of 25-OH-Vitamin D), a regression CART tree was built. The calculated percentages of normalized importance for each independent variable reveal that the most important predictors, affecting Vitamin D, are body mass index (100%), alcohol (84.2%), education (70.3%), coffee (70.2%), Са_Vit D (69.8%), and sports frequency (42.4%), while the other variables have much less importance.

CONCLUSION: The application of the CART method makes it possible to study the distribution and importance of the factors influencing the state of vitamin D. The presence of such a high percentage of women at risk requires a comprehensive approach, including educational programs and strict application of guidelines for vitamin D supplementation to prevent the effects of hypovitaminosis.

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References

Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, Tmava Berisha A, et al. Vitamin D deficiency 2.0: An update on the current status worldwide. Eur J Clin Nutr. 2020;74(11):1498-513. https://doi.org/10.1038/s41430-020-0558-y PMid:31959942 DOI: https://doi.org/10.1038/s41430-020-0558-y

Meeham M, Penckofer S. The role of vitamin D in the aging. J Aging Gerontol. 2014;2(2):60-71. https://doi.org/10.12974/2309-6128.2014.02.02.1 PMid:25893188 DOI: https://doi.org/10.12974/2309-6128.2014.02.02.1

Buttros D, Nahas-Neto J, Nahas E, Cangussu LM, Barral AB, Kawakami MS. Risk factors for osteoporosis in postmenopausal women from southeast Brazilian. Rev Bras Ginecol Obstet. 2011;33(6):295-302. https://doi.org/10.1590/s0100-72032011000600006 PMid:21877019 DOI: https://doi.org/10.1590/S0100-72032011000600006

Tsiaras WG, Weinstock MA. Factors influencing vitamin D status. Acta Derm Venereol. 2011;9(1):115-24. https://doi.org/10.2340/00015555-0980 PMid:21384086 DOI: https://doi.org/10.2340/00015555-0980

Sowah D, Fan X, Dennett L, Hagtvedt R, Straube S. Vitamin D levels and deficiency with different occupations: A systematic review. BMC Public Health. 2017;17(1):519. https://doi.org/10.1186/s12889-017-4436-z PMid:28637448 DOI: https://doi.org/10.1186/s12889-017-4436-z

Divakar U, Sathish T, Soljak M, Bajpai R, Dunleavy G, Visvalingam N, et al. Prevalence of Vitamin D deficiency and its associated work-related factors among indoor workers in a multi-ethnic Southeast Asian country. Int J Environ Res Public Health. 2020;17(1):164. https://doi.org/10.3390/ijerph17010164 PMid:31881679 DOI: https://doi.org/10.3390/ijerph17010164

Goulet J, Provencher V, Piché ME, Lapointe A, John Weisnagel S, Nadeau A, et al. Relationship between eating behaviors and food and drink consumption in healthy postmenopausal women in a real-life context. Br J Nutr. 2008;100(4):910-7. https://doi.org/10.1017/S0007114508925459 PMid:18279556 DOI: https://doi.org/10.1017/S0007114508925459

Semra RD, Garrett E, Johnson BA, Guralnik JM, Fried LP. Vitamin D deficiency among older women with and without disability. Am J Clin Nutr. 2000;72(6):1529-34. https://doi.org/10.1093/ajcn/72.6.1529 PMid:11101482 DOI: https://doi.org/10.1093/ajcn/72.6.1529

Lowe NM, Mitra SR, Foster PC, Bhojani I, McCann J. Vitamin D status and markers of bone turnover in Caucasian and South Asian postmenopausal women living in the UK. Br J Nutr. 2010;103(12):1706-10. https://doi.org/10.1017/S0007114509993850 PMid:20102676 DOI: https://doi.org/10.1017/S0007114509993850

Brejman L, Frieman J, Olshen R, Stone CJ. Classification and Regression Trees. New York: Chapman & Hall; 1984.

Borissova A-M, Shinkov A, Vlahov J, Dakovska L, Todorov T, Svinarov D, et al. Frequency of deficiency, insufficiency and sufficiency of vitamin D in Bulgarian population (≥20-80 years old). Endocrinologia. 2012;17(3):122-34.

Vimaleswaran KS, Berr DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, et al. Causal relationship between obesity and vitamin D status: Bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10(2):e1001383. https://doi.org/10.1371/journal.pmed.1001383 PMid:23393431 DOI: https://doi.org/10.1371/journal.pmed.1001383

Larose CY, Camargo JR, Langhammer A, Romundstad P, Mai XM. Factors associated with vitamin D deficiency in a Norwegian population: The HUNT study. J Epidemiol Community Health. 2014;68(2):165-70. https://doi.org/10.1136/jech-2013-202587 PMid:24197920 DOI: https://doi.org/10.1136/jech-2013-202587

Skaaby T, Husemoen LL, Thuesen BH, Pisinger C, Hannemann A, Jørgensen T, et al. Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements. Endocrine. 2016;51(2):342-50. https://doi.org/10.1007/s12020-015-0641-7 PMid:26024976 DOI: https://doi.org/10.1007/s12020-015-0641-7

Tardelli VS, Lago M, Silveira DX, Fidalgo TM. Vitamin D and alcohol: A review of the current literature. Psychiatry Res. 2017;248:83-6. https://doi.org/10.1016/j.psychres.2016.10.051 PMid:28033511 DOI: https://doi.org/10.1016/j.psychres.2016.10.051

Ogunsakin O, Hottor T, Mehta A, Lichtveld M, McCaskill M. Chronic ethanol exposure effects on vitamin D levels among subjects with alcohol use disorder. Environ Health Insights. 2016;10:191-9. https://doi.org/10.4137/EHI.S40335 PMid:27795667 DOI: https://doi.org/10.4137/EHI.S40335

Rapuri PB, Gallagher JC, Nawaz Z. Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. J Steroid Biochem Mol Biol. 2007;103(3-5):368-71. https://doi.org/10.1016/j.jsbmb.2006.12.037 PMid:17223552 DOI: https://doi.org/10.1016/j.jsbmb.2006.12.037

Koundourakis NE, Margioris AN. Vitamin D and physical activity. In: A Critical Evaluation of Vitamin D-Basic Overview. London:IntechOpen; 2017. https://doi.org/10.5772/65103 DOI: https://doi.org/10.5772/65103

Nascimento NAP, Moreira PFP, Carvalho VA, Aragão L, Marin-Mio RV, Lazaretti-Castro M, et al. Effect of vitamin D level and physical exercise on the physical performance and functional test results in elderly women. J Geriatr Med Gerontol. 2019;5(1):061.

Lee CJ, Kim SS, Suh WY, Kim JS, Jung JG, Yoon SJ, et al. The effect of education and vitamin D supplementation on the achievement of optimal vitamin D level in Korean postmenopausal women. J Bone Metab. 2019;26(3):193-9. https://doi.org/10.11005/jbm.2019.26.3.193 PMid:31555616 DOI: https://doi.org/10.11005/jbm.2019.26.3.193

Leger-Guist’hau J, Domingues-Faria C, Miolanne M, Peyrol F, Gerbaud L, Perreira B, et al. Low socio-economic status is a newly identified independent risk factor for poor vitamin D status in severely obese adults. J Hum Nutr Diet. 2017;30(2):203-15. https://doi.org/10.1111/jhn.12405 PMid:27524803 DOI: https://doi.org/10.1111/jhn.12405

Sutherland JP, Zhou A, Leach MJ, Hyppönen E. Differences and determinants of vitamin D deficiency among UK biobank participants: A cross-ethnic and socioeconomic study. Clin Nutr. 2020;40(5):3436-47. https://doi.org/10.1016/j.clnu.2020.11.019 PMid:33309415 DOI: https://doi.org/10.1016/j.clnu.2020.11.019

Purdon G, Comrie F, Rutherford L, Marcinkiewicz A.“Vitamin D Status of Scottish Adults: Results from the 2010 & 2011,” Scottish Health Surveys; 2013.

Davis SV. The Relationship Between Socioeconomic Status and Body Mass Index on Vitamin D Levels in African American Women with and without Diabetes Living in Areas with Abundant Sunshine, Graduate Theses and Dissertations, University of South Florida; 2013.

Wyskida M, Owczarek A, Szybalska A, Brzozowska A, Szczerbowska I, Wieczorowska-Tobis K, et al. Socio- economic determinants of vitamin D deficiency in the older Polish population: Results from the PolSenior study. Public Health Nutr. 2018;21(11):1995-2003. https://doi.org/10.1017/ S1368980017003901 PMid:29352837 DOI: https://doi.org/10.1017/S1368980017003901

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Published

2023-01-02

How to Cite

1.
Yordanova A, Tolekova A, Teneva P, Dobreva I, Kichukova K. Determination of Factors Affecting Vitamin D Levels in Women at Risk Using Classification and Regression Tree Analysis. Open Access Maced J Med Sci [Internet]. 2023 Jan. 2 [cited 2024 Apr. 29];11(A):70-5. Available from: https://oamjms.eu/index.php/mjms/article/view/11340

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