Relationship Between Pulmonary Vascular Dilatation and Clinical Symptoms on Chest Computed Tomography in Patients with Confirmed COVID-19
DOI:
https://doi.org/10.3889/oamjms.2023.11349Keywords:
COVID-19, Chest computed tomography, Pulmonary vascular dilatationAbstract
Introduction: Chest computed tomography (CT) is important in establishing a diagnosis, including detecting pulmonary vascular dilatation as a radiological feature of COVID-19, and consequently in providing comprehensive treatment. This study aimed to analyze the relationship between pulmonary vascular dilatation and clinical symptoms on chest CT in patients with confirmed COVID-19.
Methods: This retrospective cross-sectional study was conducted at the Radiology Department of Dr. Wahidin Sudirohusodo Hospital and Hasanuddin University Hospital, Makassar, Indonesia, from July to September 2021 in a total of 231 patients with confirmed COVID-19. The chi-squared correlation test was used to analyze the data, with p-values of <0.05 considered significant.
Results: Pulmonary vascular dilatation was observed in 31 (37.8%) of the 82 patients with confirmed COVID-19 with mild-to-moderate clinical symptoms and in 51 (69.8%) of the 73 patients with confirmed COVID-19 with severe-to-critical clinical symptoms. The incidence of pulmonary vascular dilatation increased in the patients with confirmed COVID-19 with severe-to-critical clinical symptoms. The chief complaints of most patients were cough, shortness of breath, and fever. In the patients with mild-to-moderate clinical symptoms, the most common chief complaint was cough (n=53; 64.63%), while in those with severe-to-critical clinical symptoms, the most common chief complaint was shortness of breath (n=60; 82.19%).
Conclusions: Based on chest CT findings, pulmonary vascular dilatation is related to clinical symptoms in patients with confirmed COVID-19.
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Massi MN, Sjahril R, Halik H, Soraya GV, Hidayah N, Pratama MY, et al. Sequence analysis of SARS-CoV-2 Delta variant isolated from Makassar, South Sulawesi, Indonesia. Heliyon. 2023;9:e13382. https://doi.org/10.1016/j.heliyon.2023.e13382 PMid:36744069 DOI: https://doi.org/10.1016/j.heliyon.2023.e13382
Oley MH, Oley MC, Kepel BJ, Tjandra DE, Langi FL, Herwen, et al. ICAM-1 levels in patients with covid-19 with diabetic foot ulcers: A prospective study in Southeast Asia. Ann Med Surg. 2021;63:102171. https://doi.org/10.1016/j.amsu.2021.02.017 PMid:33585030 DOI: https://doi.org/10.1016/j.amsu.2021.02.017
da Rosa Mesquita R, Francelino Silva Junior LC, Santos Santana FM, de Oliveira TF, Alcântara RC, Arnozo GM, et al. Clinical manifestations of COVID-19 in the general population: Systematic review. Wien Klin Wochenschr. 2021;133(7-8):377-82. https://doi.org/10.1007/s00508-020-01760-4 PMid:33242148 DOI: https://doi.org/10.1007/s00508-020-01760-4
Qanadli SD, Beigelman-Aubry C, Rotzinger DC. Vascular changes detected with thoracic CT in coronavirus disease (COVID-19) might be significant determinants for accurate diagnosis and optimal patient management. AJR Am J Roentgenol. 2020;215(1):W15. https://doi.org/10.2214/AJR.20.23185 PMid:32255684 DOI: https://doi.org/10.2214/AJR.20.23185
Lv H, Chen T, Pan Y, Wang H, Chen L, Lu Y. Pulmonary vascular enlargement on thoracic CT for diagnosis and differential diagnosis of COVID-19: A systematic review and meta-analysis. Ann Transl Med. 2020;8(14):878. https://doi.org/10.21037/atm-20-4955 PMid:32793722 DOI: https://doi.org/10.21037/atm-20-4955
Bai HX, Hsieh B, Xiong Z, Halsey K, Choi JW, Tran TM, et al. Performance of radiologists in differentiating COVID-19 from non-COVID-19 viral pneumonia at chest CT. Radiology. 2020;296(2):E46-54. https://doi.org/10.1148/radiol.2020200823 PMid:32155105 DOI: https://doi.org/10.1148/radiol.2020200823
Parry AH, Wani AH. Segmental pulmonary vascular changes in COVID-19 pneumonia. AJR Am J Roentgenol. 2020;215(3):W33. https://doi.org/10.2214/AJR.20.23443 PMid:32383969 DOI: https://doi.org/10.2214/AJR.20.23443
Hegazy MA, Lithy RM, Abdel-Hamid HM, Wahba M, Ashoush OA, Hegazy MT, et al. COVID-19 disease outcomes: Does gastrointestinal burden play a role? Clin Exp Gastroenterol. 2021;14:199-207. https://doi.org/10.2147/CEG.S297428 PMid:34079323 DOI: https://doi.org/10.2147/CEG.S297428
Zayed NE, Abbas A, Lutfy SM. Criteria and potential predictors of severity in patients with COVID-19. Egypt J Bronchol. 2022;16(1):11. https://doi.org/10.1186/s43168-022-00116-y DOI: https://doi.org/10.1186/s43168-022-00116-y
Li Y, Xia L. Coronavirus disease 2019 (COVID-19): Role of chest CT in diagnosis and management. AJR Am J Roentgenol. 2020;214(6):1280-6. https://doi.org/10.2214/AJR.20.22954 PMid:32130038 DOI: https://doi.org/10.2214/AJR.20.22954
Prokop M, van Everdingen W, van Rees Vellinga T, van Ufford HQ, Stöger L, Beenen L, et al. CO-RADS: A categorical CT assessment scheme for patients suspected of having COVID-19- definition and evaluation. Radiology. 2020;296(2):E97-104. https://doi.org/10.1148/radiol.2020201473 PMid:32339082 DOI: https://doi.org/10.1148/radiol.2020201473
Caruso D, Zerunian M, Polici M, Pucciarelli F, Polidori T, Rucci C, et al. Chest CT features of COVID-19 in Rome, Italy. Radiology. 2020;296(2):E79-85. https://doi.org/10.1148/radiol.2020201237 PMid:32243238 DOI: https://doi.org/10.1148/radiol.2020201237
Foresta C, Rocca MS, Di Nisio A. Gender susceptibility to COVID-19: A review of the putative role of sex hormones and X chromosome. J Endocrinol Invest. 2021;44(5):951-6. https://doi.org/10.1007/s40618-020-01383-6 PMid:32936429 DOI: https://doi.org/10.1007/s40618-020-01383-6
Revzin MV, Raza S, Warshawsky R, D’Agostino C, Srivastava NC, Bader AS, et al. Multisystem imaging manifestations of COVID-19, part 1: Viral pathogenesis and pulmonary and vascular system complications. RadioGraphics. 2020;40(6):1574-99. https://doi.org/10.1148/rg.2020200149 PMid:33001783 DOI: https://doi.org/10.1148/rg.2020200149
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395(10229):1054-62. https://doi.org/10.1016/S0140-6736(20)30566-3 PMid:32171076 DOI: https://doi.org/10.1016/S0140-6736(20)30566-3
Dai WC, Zhang HW, Yu J, Xu HJ, Chen H, Luo SP, et al. CT imaging and differential diagnosis of COVID-19. Can Assoc Radiol J. 2020;71(2):195-200. https://doi.org/10.1177/0846537120913033 PMid:32129670 DOI: https://doi.org/10.1177/0846537120913033
Wu D, Wu T, Liu Q, Yang Z. The SARS-CoV-2 outbreak: What we know. Int J Infect Dis. 2020;94:44-8. https://doi.org/10.1016/j.ijid.2020.03.004 PMid:32171952 DOI: https://doi.org/10.1016/j.ijid.2020.03.004
Tu H, Tu S, Gao S, Shao A, Sheng J. Current epidemiological and clinical features of COVID-19; a global perspective from China. J Infect. 2020;81(1):1-9. https://doi.org/10.1016/j.jinf.2020.04.011 PMid:32315723 DOI: https://doi.org/10.1016/j.jinf.2020.04.011
Mungroo MR, Khan NA, Siddiqui R. Novel coronavirus: Current understanding of clinical features, diagnosis, pathogenesis, and treatment options. Pathogens. 2020;9(4):297. https://doi.org/10.3390/pathogens9040297 PMid:32316618 DOI: https://doi.org/10.3390/pathogens9040297
Reynolds AS, Lee AG, Renz J, DeSantis K, Liang J, Powell CA, et al. Pulmonary vascular dilatation detected by automated transcranial doppler in COVID-19 pneumonia. Am J Respir Crit Care Med. 2020;202(7):1037-9. https://doi.org/10.1164/rccm.202006-2219LE PMid:32757969 DOI: https://doi.org/10.1164/rccm.202006-2219LE
Qanadli SD, Rotzinger DC. Vascular abnormalities as part of chest CT findings in COVID-19. Radiol Cardiothorac Imaging. 2020;2(2):e200161. https://doi.org/10.1148/ryct.2020200161 DOI: https://doi.org/10.1148/ryct.2020200161
Zhao W, Zhong Z, Xie X, Yu Q, Liu J. Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: A multicenter study. AJR Am J Roentgenol. 2020;214(5):1072-7. https://doi.org/10.2214/AJR.20.22976 PMid:32125873 DOI: https://doi.org/10.2214/AJR.20.22976
Wang C, Shi B, Wei C, Ding H, Gu J, Dong J. Initial CT features and dynamic evolution of early-stage patients with COVID-19. Radiol Infect Dis. 2020;7(4):195-203. https://doi.org/10.1016/j.jrid.2020.08.002 PMid:32864406 DOI: https://doi.org/10.1016/j.jrid.2020.08.002
Oudkerk M, Büller HR, Kuijpers D, van Es N, Oudkerk SF, McLoud T, et al. Diagnosis, prevention, and treatment of thromboembolic complications in COVID-19: Report of the National Institute for Public Health of the Netherlands. Radiology. 2020;297(1):E216-22. https://doi.org/10.1148/radiol.2020201629 PMid:32324101 DOI: https://doi.org/10.1148/radiol.2020201629
Lang M, Som A, Carey D, Reid N, Mendoza DP, Flores EJ, et al. Pulmonary vascular manifestations of COVID-19 pneumonia. Radiol Cardiothorac Imaging. 2020;2(3):e200277. https://doi.org/10.1148/ryct.2020200277 PMid:34036264 DOI: https://doi.org/10.1148/ryct.2020200277
Levi M, Coppens M. Vascular mechanisms and manifestations of COVID-19. Lancet Respir Med. 2021;9(6):551-3. https://doi.org/10.1016/S2213-2600(21)00221-6 PMid:34015324 DOI: https://doi.org/10.1016/S2213-2600(21)00221-6
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Copyright (c) 2023 Sri Asriyani, Nikmatia Latief, Andi Alfian Zainuddin, Muzakkir Amir, Bachtiar Murtala, Hendra Toreh (Author)
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