Tyramine Ingestion and Migraine Attack: A Systematic Review

Harvey Sudharta; Octavianus Darmawan; Jimmy F. A.  Barus

doi:10.3889/oamjms.2023.11484

Authors

Harvey Sudharta Department of Neurology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Atma Jaya Neuroscience and Cognitive Center, Jakarta, Indonesia https://orcid.org/0000-0002-6640-9496
Octavianus Darmawan Atma Jaya Neuroscience and Cognitive Center, Department of Neurology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
Jimmy F. A. Barus Department of Neurology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Atma Jaya Neuroscience and Cognitive Center, Jakarta, Indonesia https://orcid.org/0000-0001-5227-5207

DOI:

https://doi.org/10.3889/oamjms.2023.11484

Keywords:

tyramine, 4-hydroxyphenethylamine, migraine, headache

Abstract

AIM: This systematic review aimed to clarify the association between tyramine ingestion (food/capsule) with the occurrence of a migraine attack.

METHODS: Based on a comprehensive search of PubMed, PMC, ProQuest, and EBSCOhost, we included all studies that observed migraine headaches after tyramine ingestion. Association was evaluated with the control (placebo) group as a comparison. We further assessed the abstracts and full texts of selected papers. We included articles fulfilling the inclusion criteria in this systematic review.

RESULTS: Seven non-randomized studies with 322 eligible subjects (168 women, 63 men, and 91 unknown genders) aged 4 to 62 years old were included in the study. A high to moderate (17.2–50%) occurrence of headache after tyramine ingestion was observed. Similar results were observed in the control (placebo) group (0–42.1%). Quality appraisal on all seven non-randomized studies using ROBINS-I showed that six studies had a moderate risk of bias, and one study had a serious risk of bias.

CONCLUSION: The relationship between tyramine-containing food and migraine remains unclear.

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Author Biographies

Octavianus Darmawan, Atma Jaya Neuroscience and Cognitive Center, Department of Neurology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Octavianus Darmawan is a neurologist and a tutor in Faculty of Medicine and Health Sciences, Atma Jaya University. He is also an active member of Indonesian Neurologist Association.

Jimmy F. A. Barus, Department of Neurology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Atma Jaya Neuroscience and Cognitive Center, Jakarta, Indonesia

Academic Staff

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