Vitamin D and Diagnostic Colonoscopy for Colorectal Cancer in Indonesian Population: A Cross-sectional Study

Andriana Purnama; Kiki Lukman; Tommy Ruchimat; Reno Rudiman; Alma Wijaya; Prapanca Nugraha

doi:10.3889/oamjms.2023.11561

Authors

Andriana Purnama Department of Surgery, Division of Digestive Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
Kiki Lukman Department of Surgery, Division of Digestive Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia https://orcid.org/0000-0001-9701-342X
Tommy Ruchimat Department of Surgery, Division of Digestive Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
Reno Rudiman Department of Surgery, Division of Digestive Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia https://orcid.org/0000-0001-6826-6313
Alma Wijaya Department of Surgery, Division of Digestive Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
Prapanca Nugraha Department of Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia https://orcid.org/0000-0001-9701-342X

DOI:

https://doi.org/10.3889/oamjms.2023.11561

Keywords:

Colonoscopy, Colorectal Cancer, Vitamin D

Abstract

BACKGROUND: Colorectal cancer (CRC) is the world’s third most common type of cancer. Case studies have shown an inverse correlation between serum Vitamin D levels and the incidence of human colorectal cancer.

AIM: This study aims to assess Vitamin D levels in patients who underwent colonoscopy for diagnostic colorectal cancer.

METHODS: This research is a cross-sectional study. This study’s subjects were patients who visited the Digestive Surgery polyclinic and underwent a colonoscopy to diagnose colorectal cancer. Level of Vitamin D was collected before the colonoscopy examination and categorized into three groups: Vitamin D with a value of < 20 ng/mL indicates a deficiency, a level of 20–30 ng/mL as an insufficiency level, and a value > 30 ng/mL as a sufficient value. A colonoscopy examination was performed to obtain a diagnosis of colorectal cancer based on anatomical pathology examination.

RESULTS: Examination of Vitamin D levels from 120 subjects showed that the average vitamin level was 16.36 ng/mL, which indicates Vitamin D deficiency levels. A total of 85 (70.8%) subjects showed Vitamin D deficiency, as many as 24 (20%) showed Vitamin D insufficiency levels, and only 11 (9.2%) study subjects showed sufficient Vitamin D levels. The colonoscopy showed 60 (50%) subjects with colorectal cancer. The relationship between Vitamin D levels and the diagnosis of CRC showed a value of p = 0.60 (p > 0.05).

CONCLUSION: There is no significant difference between low levels of Vitamin D and the diagnosis of colorectal cancer patients.

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