A Cross-sectional Study on the Association of KIBRA Genetic Polymorphism with Episodic Memory in North Jordanian Adults

Mohammad Ismail AlKhatib; Ahmed O. Maslat; Esraa Al-Haj Ali; Thaer Al-Saqqar; Raida Khalil

doi:10.3889/oamjms.2023.11563

Authors

Mohammad Ismail AlKhatib Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan
Ahmed O. Maslat Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan; Faculty of Pharmacy, Jadara University, Irbid, Jordan
Esraa Al-Haj Ali Department of Biotechnology and Genetic Engineering, Faculty of Science, Philadelphia University, Amman, Jordan
Thaer Al-Saqqar Department of Biotechnology and Genetic Engineering, Faculty of Science, Philadelphia University, Amman, Jordan
Raida Khalil Department of Biotechnology and Genetic Engineering, Faculty of Science, Philadelphia University, Amman, Jordan

DOI:

https://doi.org/10.3889/oamjms.2023.11563

Keywords:

Episodic memory, Immediate memory, KIBRA

Abstract

One of the cognitive processes most damaged by aging and thought to be the system most susceptible to neurodegenerative illnesses is episodic memory. Recently, episodic memory function has been linked to a single nucleotide polymorphism (rs17070145) in the ninth intron of the KIBRA gene (kidney and brain expressed gene). This study looked at the relationship between the KIBRA polymorphism (rs17070145) and the episodic memory abilities assessed by the Rey Auditory Verbal Learning Test and Rey Complex Figure Test at various time points (20-minute, 30-minute, 24-hours and 6-month). 112 healthy adult Jordanians between the ages of 18 and 45 were included in the study, and the genotypes at the KIBRA (rs17070145) polymorphic site were identified using the PCR-RFLP method. The outcomes did not reveal any statistically significant any assessment of verbal and visual episodic memory tests and the KIBRA polymorphism. The findings also indicated that KIBRA polymorphism had no statistically significant impact on short-term memory or learning capacity, indicating that KIBRA had no effect on a person's ability to pay attention or concentrate. Additionally, in the Jordanian population, the genotype percentages for KIBRA rs17070145 were: 10.7% for TT, 43.8% for TC, and 45.5% for CC, and the percentage of the T allele was 0.326. The current investigation discovered no statistically significant differences between the Jordanian population and either the European or the South Asian populations in terms of the percentages of alleles and genotypes of the KIBRA rs17070145 gene.

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