Intima–Media Thickness in Primary Aldosteronism Compared with Essential Hypertension: A Meta-analysis

Authors

  • Eva Muja Department of Cardiology, Catholic University “Our Lady of Good Counsel”, Tirana, Albania https://orcid.org/0000-0001-7507-6307
  • Ilirian Laçi Department of Radiology, Medical University of Tirana, Tirana, Albania https://orcid.org/0000-0001-9480-0065
  • Sonil Marko Department of Internal Medicine, Medical University of Tirana, Tirana, Albania
  • Ilir Akshija Department of Statistics, Medical University of Tirana, Tirana, Albania

DOI:

https://doi.org/10.3889/oamjms.2024.11594

Keywords:

essential hypertension, intima media, primary aldosteronism

Abstract

AIM: This study was comparison of the intima–media thickness in the primary aldosteronism (PA) patients versus essential hypertension (EH) patients.

METHODS: We searched on PubMed for studies about intima–media thickness in PA and found 317 articles. After the title and abstract reading, we excluded 291 studies because they did not fit in our criteria. After the final assessment of the 26 articles, seven of them were chosen as final studies to be included in the meta-analysis.

RESULTS: In this study, we included seven studies with a total of participants of 534 patients. The main outcome was a comparison of intima–media thickness between patients with PA, EHs and healthy controls. The result shows a thicker intima media in PA patients in comparison with EH patients and more over with healthy controls, but this was not statistically significant.

CONCLUSION: PA predisposes to a thicker intima media in comparison to EH, but we need for larger studies to have significant results.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Monticone S, Burrello J, Tizzani D, Bertello C, Viola A, Buffolo F, et al. Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice. J Am Coll Cardiol. 2017;69(14):1811-20. https://doi.org/10.1016/j.jacc.2017.01.052 PMid:28385310 DOI: https://doi.org/10.1016/j.jacc.2017.01.052

Rossi GP, Bernini G, Caliumi C, Desideri G, Fabris B, Ferri C, et al. A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. J Am Coll Cardiol. 2006;48(11):2293-300. https://doi.org/10.1016/j.jacc.2006.07.059 PMid:17161262 DOI: https://doi.org/10.1016/j.jacc.2006.07.059

Chen ZW, Tsai CH, Pan CT, Chou CH, Liao CW, Hung CS, et al. Endothelial dysfunction in primary aldosteronism. Int J Mol Sci. 2019;20(20):5214. https://doi.org/10.3390/ijms20205214 PMid:31640178 DOI: https://doi.org/10.3390/ijms20205214

Ambrosino P, Lupoli R, Tortora A Cacciapuoti M, Lupoli GA, Tarantino P, et al. Cardiovascular risk markers in patients with primary aldosteronism: A systematic review and meta-analysis of literature studies. Int J Cardiol. 2016;208:46-55. https://doi.org/10.1016/j.ijcard.2016.01.200 PMid:26826789 DOI: https://doi.org/10.1016/j.ijcard.2016.01.200

Lin YH, Lin LY, Chen A, Wu XM, Lee JK, Su TC, et al. Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma. Atherosclerosis. 2012;221(1):154-9. https://doi.org/10.1016/j.atherosclerosis.2011.12.003 PMid:22197109 DOI: https://doi.org/10.1016/j.atherosclerosis.2011.12.003

Holaj R, Zelinka T, Wichterle D, Petrák O, Strauch B, Widimský J Jr. Increased intima-media thickness of the common carotid artery in primary aldosteronism in comparison with essential hypertension. J Hypertens. 2007;25:1451-7. https://doi.org/10.1097/HJH.0b013e3281268532 PMid:17563568 DOI: https://doi.org/10.1097/HJH.0b013e3281268532

Bernini G, Galetta F, Franzoni F, Bardini M, Taurino C, Bernardini M, et al. Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronism. J Hypertens. 2008;26(12):2399-405. https://doi.org/10.1097/HJH.0b013e32831286fd PMid:19008719 DOI: https://doi.org/10.1097/HJH.0b013e32831286fd

Rossi GP, Sacchetto A, Visentin P, Canali C, Graniero GR, Palatini P, et al. Changes in left ventricular anatomy and function in hypertension and primary aldosteronism. Hypertension. 1996;27(5):1039-45. https://doi.org/10.1161/01.hyp.27.5.1039 PMid:8621194 DOI: https://doi.org/10.1161/01.HYP.27.5.1039

Shigematsu Y, Hamada M, Okayama H, Hara Y, Hayashi Y, Kodama K, et al. Left ventricular hypertrophy precedes other target-organ damage in primary aldosteronism. Hypertension. 1997;29(3):723-7. https://doi.org/10.1161/01.hyp.29.3.723 PMid:9052887 DOI: https://doi.org/10.1161/01.HYP.29.3.723

Matsumura K, Fujii K, Oniki H, Oka M, Iida M. Role of aldosterone in left ventricular hypertrophy in hypertension. Am J Hypertens. 2006;19(1):13-8. https://doi.org/10.1016/j.amjhyper.2005.05.013 PMid:16461184 DOI: https://doi.org/10.1016/j.amjhyper.2005.05.013

Reincke M, Fischer E, Gerum S, Merkle K, Schulz S, Pallauf A, et al. Observational study mortality in treated primary aldosteronism: The German Conn’s registry. Hypertension. 2012;60(3):618-24. https://doi.org/10.1161/HYPERTENSIONAHA.112.197111 PMid:22824982 DOI: https://doi.org/10.1161/HYPERTENSIONAHA.112.197111

Milliez P, Girerd X, Plouin PF, Blacher J, Safar ME, Mourad JJ. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol. 2005;45(8):1243-8. https://doi.org/10.1016/j.jacc.2005.01.015 PMid:15837256 DOI: https://doi.org/10.1016/j.jacc.2005.01.015

Stowasser M, Sharman J, Leano R, Gordon RD, Ward G, Cowley D, et al. Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism Type I. J Clin Endocrinol Metab. 2005;90(9):5070-6. https://doi.org/10.1210/jc.2005-0681 PMid:15941863 DOI: https://doi.org/10.1210/jc.2005-0681

Grasman R. Meta-Analysis in JASP. Web Publication/Site, JASP; 2017. Available from: https://jaspstats.org/2017/11/15/ meta-analysis-jasp [Last accessed on 2023 Jan 12].

Wu X, Yu J, Tian H. Cardiovascular risk in primary aldosteronism. A systematic review and meta-analysis. Medicine (Baltimore). 2019;98(26):e15985. https://doi.org/10.1097/MD.0000000000015985 PMid:31261504 DOI: https://doi.org/10.1097/MD.0000000000015985

Benitah JP, Perrier E, Gomez AM, Vassort G. Effects of aldosterone on transient outward K+ current density in rat ventricular myocytes. J Physiol. 2001;537(Pt 1):151-60. https://doi.org/10.1111/j.1469-7793.2001.0151k.x PMid:11711569 DOI: https://doi.org/10.1111/j.1469-7793.2001.0151k.x

Tanabe A, Naruse M, Naruse K, Hase M, Yoshimoto T, Tanaka M, et al. Left ventricular hypertrophy is more prominent in patients with primary aldosteronism than in patients with other types of secondary hypertension. Hypertens Res. 1997;20(2):85-90. https://doi.org/10.1291/hypres.20.85 PMid:9220271 DOI: https://doi.org/10.1291/hypres.20.85

Chang YY, Liao CW, Tsai CH, Chen CW, Pan CT, Chen ZW, et al. Left ventricular dysfunction in patients with primary aldosteronism: A propensity score-matching follow-up study with tissue Doppler imaging. J Am Heart Assoc. 2019;8(22):e013263. https://doi.org/10.1161/JAHA.119.013263 PMid:31718437 DOI: https://doi.org/10.1161/JAHA.119.013263

Cesari M, Letizia C, Angeli P, Sciomer S, Rosi S, Rossi GP. Cardiac remodeling in patients with primary and secondary aldosteronism: A tissue doppler study. Circ Cardiovasc Imaging. 2016;9(6):e004815. https://doi.org/10.1161/CIRCIMAGING.116.004815 PMid:27307552 DOI: https://doi.org/10.1161/CIRCIMAGING.116.004815

Widimsky J Jr., Strauch B, Petrák O, Rosa J, Somloova Z, Zelinka T. Vascular disturbances in primary aldosteronism: Clinical evidence. Kidney Blood Press Res. 2012;35(6):529-33. https://doi.org/10.1159/000340031 PMid:22890049 DOI: https://doi.org/10.1159/000340031

Rosa J, Somlóová Z, Petrák O, Strauch B, Indra T, Senitko M. Peripheral arterial stiffness in primary aldosteronism. Physiol Res. 2012;61(5):461-8. https://doi.org/10.33549/physiolres.932344 PMid:2288123 DOI: https://doi.org/10.33549/physiolres.932344

Lee MY, Lai WT. Plasma renin level and aldosterone to renin ratio are associated with presence of carotid plaques in patients with stable coronary artery disease. J Renin Angiotensin Aldosterone Syst. 2015;16(4):1159-67. https://doi.org/10.1177/1470320314548743 PMid:25237165 DOI: https://doi.org/10.1177/1470320314548743

Downloads

Published

2024-01-28

How to Cite

1.
Muja E, Laçi I, Marko S, Akshija I. Intima–Media Thickness in Primary Aldosteronism Compared with Essential Hypertension: A Meta-analysis. Open Access Maced J Med Sci [Internet]. 2024 Jan. 28 [cited 2024 Apr. 29];12(1):56-61. Available from: https://oamjms.eu/index.php/mjms/article/view/11594

Issue

Section

Meta-analytic Review Article

Categories