Intima–Media Thickness in Primary Aldosteronism Compared with Essential Hypertension: A Meta-analysis


  • Eva Muja Department of Cardiology, Catholic University “Our Lady of Good Counsel”, Tirana, Albania
  • Ilirian Laçi Department of Radiology, Medical University of Tirana, Tirana, Albania
  • Sonil Marko Department of Internal Medicine, Medical University of Tirana, Tirana, Albania
  • Ilir Akshija Department of Statistics, Medical University of Tirana, Tirana, Albania



essential hypertension, intima media, primary aldosteronism


AIM: This study was comparison of the intima–media thickness in the primary aldosteronism (PA) patients versus essential hypertension (EH) patients.

METHODS: We searched on PubMed for studies about intima–media thickness in PA and found 317 articles. After the title and abstract reading, we excluded 291 studies because they did not fit in our criteria. After the final assessment of the 26 articles, seven of them were chosen as final studies to be included in the meta-analysis.

RESULTS: In this study, we included seven studies with a total of participants of 534 patients. The main outcome was a comparison of intima–media thickness between patients with PA, EHs and healthy controls. The result shows a thicker intima media in PA patients in comparison with EH patients and more over with healthy controls, but this was not statistically significant.

CONCLUSION: PA predisposes to a thicker intima media in comparison to EH, but we need for larger studies to have significant results.


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Monticone S, Burrello J, Tizzani D, Bertello C, Viola A, Buffolo F, et al. Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice. J Am Coll Cardiol. 2017;69(14):1811-20. PMid:28385310 DOI:

Rossi GP, Bernini G, Caliumi C, Desideri G, Fabris B, Ferri C, et al. A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. J Am Coll Cardiol. 2006;48(11):2293-300. PMid:17161262 DOI:

Chen ZW, Tsai CH, Pan CT, Chou CH, Liao CW, Hung CS, et al. Endothelial dysfunction in primary aldosteronism. Int J Mol Sci. 2019;20(20):5214. PMid:31640178 DOI:

Ambrosino P, Lupoli R, Tortora A Cacciapuoti M, Lupoli GA, Tarantino P, et al. Cardiovascular risk markers in patients with primary aldosteronism: A systematic review and meta-analysis of literature studies. Int J Cardiol. 2016;208:46-55. PMid:26826789 DOI:

Lin YH, Lin LY, Chen A, Wu XM, Lee JK, Su TC, et al. Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma. Atherosclerosis. 2012;221(1):154-9. PMid:22197109 DOI:

Holaj R, Zelinka T, Wichterle D, Petrák O, Strauch B, Widimský J Jr. Increased intima-media thickness of the common carotid artery in primary aldosteronism in comparison with essential hypertension. J Hypertens. 2007;25:1451-7. PMid:17563568 DOI:

Bernini G, Galetta F, Franzoni F, Bardini M, Taurino C, Bernardini M, et al. Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronism. J Hypertens. 2008;26(12):2399-405. PMid:19008719 DOI:

Rossi GP, Sacchetto A, Visentin P, Canali C, Graniero GR, Palatini P, et al. Changes in left ventricular anatomy and function in hypertension and primary aldosteronism. Hypertension. 1996;27(5):1039-45. PMid:8621194 DOI:

Shigematsu Y, Hamada M, Okayama H, Hara Y, Hayashi Y, Kodama K, et al. Left ventricular hypertrophy precedes other target-organ damage in primary aldosteronism. Hypertension. 1997;29(3):723-7. PMid:9052887 DOI:

Matsumura K, Fujii K, Oniki H, Oka M, Iida M. Role of aldosterone in left ventricular hypertrophy in hypertension. Am J Hypertens. 2006;19(1):13-8. PMid:16461184 DOI:

Reincke M, Fischer E, Gerum S, Merkle K, Schulz S, Pallauf A, et al. Observational study mortality in treated primary aldosteronism: The German Conn’s registry. Hypertension. 2012;60(3):618-24. PMid:22824982 DOI:

Milliez P, Girerd X, Plouin PF, Blacher J, Safar ME, Mourad JJ. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol. 2005;45(8):1243-8. PMid:15837256 DOI:

Stowasser M, Sharman J, Leano R, Gordon RD, Ward G, Cowley D, et al. Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism Type I. J Clin Endocrinol Metab. 2005;90(9):5070-6. PMid:15941863 DOI:

Grasman R. Meta-Analysis in JASP. Web Publication/Site, JASP; 2017. Available from: meta-analysis-jasp [Last accessed on 2023 Jan 12].

Wu X, Yu J, Tian H. Cardiovascular risk in primary aldosteronism. A systematic review and meta-analysis. Medicine (Baltimore). 2019;98(26):e15985. PMid:31261504 DOI:

Benitah JP, Perrier E, Gomez AM, Vassort G. Effects of aldosterone on transient outward K+ current density in rat ventricular myocytes. J Physiol. 2001;537(Pt 1):151-60. PMid:11711569 DOI:

Tanabe A, Naruse M, Naruse K, Hase M, Yoshimoto T, Tanaka M, et al. Left ventricular hypertrophy is more prominent in patients with primary aldosteronism than in patients with other types of secondary hypertension. Hypertens Res. 1997;20(2):85-90. PMid:9220271 DOI:

Chang YY, Liao CW, Tsai CH, Chen CW, Pan CT, Chen ZW, et al. Left ventricular dysfunction in patients with primary aldosteronism: A propensity score-matching follow-up study with tissue Doppler imaging. J Am Heart Assoc. 2019;8(22):e013263. PMid:31718437 DOI:

Cesari M, Letizia C, Angeli P, Sciomer S, Rosi S, Rossi GP. Cardiac remodeling in patients with primary and secondary aldosteronism: A tissue doppler study. Circ Cardiovasc Imaging. 2016;9(6):e004815. PMid:27307552 DOI:

Widimsky J Jr., Strauch B, Petrák O, Rosa J, Somloova Z, Zelinka T. Vascular disturbances in primary aldosteronism: Clinical evidence. Kidney Blood Press Res. 2012;35(6):529-33. PMid:22890049 DOI:

Rosa J, Somlóová Z, Petrák O, Strauch B, Indra T, Senitko M. Peripheral arterial stiffness in primary aldosteronism. Physiol Res. 2012;61(5):461-8. PMid:2288123 DOI:

Lee MY, Lai WT. Plasma renin level and aldosterone to renin ratio are associated with presence of carotid plaques in patients with stable coronary artery disease. J Renin Angiotensin Aldosterone Syst. 2015;16(4):1159-67. PMid:25237165 DOI:




How to Cite

Muja E, Laçi I, Marko S, Akshija I. Intima–Media Thickness in Primary Aldosteronism Compared with Essential Hypertension: A Meta-analysis. Open Access Maced J Med Sci [Internet]. 2024 Jan. 28 [cited 2024 Feb. 26];12(1):56-61. Available from:



Meta-analytic Review Article