A A Young Woman with High-Grade Rectosigmoid Adenocarcinoma, no Other Specified, T2n2aM0: A Case Report and Literature Review
DOI:
https://doi.org/10.3889/oamjms.2023.11613Keywords:
Adenocarcinoma, young adult women, Colorectal cancerAbstract
BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer in which the majority of CRCs are diagnosed between the ages of 50 and 70 years. Based on current trends, the incidence of colon and rectal cancers can increase by 124% in people aged 35–49 years and at the age of 20–34 will increase by 28% and 46%.
OBJECTIVES: To report a case of a 24-year-old female patient with CRC.
CASE REPORT: A 24-year-old female patient came to the Emergency Room at Bendan Hospital, Pekalongan City, with complaints of bleeding since 1 year ago. There are complaints in the past 6 months; the patient’s weight has decreased by up to 20 kg. Rectal toucher examination revealed normal (+) anal sphincter tone, a palpable mass in the anal canal, and was fragile; there were feces and blood in gloves. Abdominal ultrasonography found a solid tumor mass in the rectum area with a volume of 181 cc, suggesting a malignancy of the rectum. During a colonoscopy, a circular, fragile, and easily bleeding tumor was found, approximately 1 cm from the anal verge, and then biopsy was performed. Histopathological examination of the colon biopsy suggests a well-differentiated, rectosigmoid, NOS adenocarcinoma. The patient then underwent surgery using the Miles procedure technique. The patient’s condition after the operation improved, so after a week of treatment, the patient was able to undergo outpatient treatment.
CONCLUSION: A complete history, physical examination, and supporting investigation are very useful in early detection of colorectal carcinoma, especially in young patients.
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Kasi PM, Shahjehan F, Cochuyt JJ, Li Z, Colibaseanu DT, Merchea A. Rising proportion of young individuals with rectal and colon cancer. Clin Colorectal Cancer. 2019;18(1):e87-95. https://doi.org/10.1016/j.clcc.2018.10.002 PMid:30420120 DOI: https://doi.org/10.1016/j.clcc.2018.10.002
Xiao JB, Leng AM, Zhang YQ, Wen Z, He J, Ye GN. CUEDC2: Multifunctional roles in carcinogenesis. Front Biosci (Landmark Ed) 2019;24(5):935-46. https://doi.org/10.2741/4759 PMid:30844721 DOI: https://doi.org/10.2741/4759
Lee SE, Jo HB, Kwack WG, Jeong YJ, Yoon YJ, Kang HW. Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population. World J Gastroenterol. 2016;22(10):2981-92. https://doi.org/10.3748/wjg.v22.i10.2981 PMid:26973394 DOI: https://doi.org/10.3748/wjg.v22.i10.2981
Troeung L, Sodhi-Berry N, Martini A, Malacova E, Ee H, O’Leary P, et al. Increasing incidence of colorectal cancer in adolescents and young adults aged 15-39 years in Western Australia 1982-2007: Examination of colonoscopy history. Front Public Health. 2017;5:179. https://doi.org/10.3389/fpubh.2017.00179 PMid:28791283 DOI: https://doi.org/10.3389/fpubh.2017.00179
Kim NH, Jung YS, Yang HJ, Park SK, Park JH, Park DI, et al. Prevalence of and risk factors for colorectal neoplasia in asymptomatic young adults (20-39 years old). Clin Gastroenterol Hepatol 2019;17(1):115-22. https://doi.org/10.1016/j.cgh.2018.07.011 PMid:30025922 DOI: https://doi.org/10.1016/j.cgh.2018.07.011
Campos FG. Colorectal cancer in young adults: A difficult challenge. World J Gastroenterol. 2017;23(28):5041-4. https://doi.org/10.3748/wjg.v23.i28.5041 PMid:28811701 DOI: https://doi.org/10.3748/wjg.v23.i28.5041
Campos FG, Figueiredo MN, Monteiro M, Nahas SC, Cecconello I. Incidence of colorectal cancer in young patients. Rev Col Bras Cir. 2017;44(2):208-15. https://doi.org/10.1590/0100-69912017002004 PMid:28658341 DOI: https://doi.org/10.1590/0100-69912017002004
Sierra MS, Forman D. Etiology of colorectal cancer (C18-20) in Central and South America. In: Cancer Central and South America Project. Lyon: International Agency for Research on Cancer; 2019l. Available from: https://www-dep.iarc.fr/CSU_ resources.htm [Last accessed on 2019 May 26].
Ulanja MB, Beutler BD, Rishi M, Ogala C, Patterson DR, Gullapalli N, et al. Colorectal cancer presentation and survival in young individuals: A retrospective cohort study. Cancers (Basel). 2018;10(12):472. https://doi.org/10.3390/cancers10120472 PMid:30487446 DOI: https://doi.org/10.3390/cancers10120472
Malekpour H, Heidari MH, Vafaee R, Farshi HM, Khodadoostan M. Gene expression analysis of colon high-grade dysplasia revealed new molecular mechanism of disease. Gastroenterol Hepatol Bed Bench. 2018 Winter;11(Suppl 1):S111-7. PMid:30774816
Dawson H, Kirsch R, Messenger D, Driman D. A review of current challenges in colorectal cancer reporting. Arch Pathol Lab Med. 2019;143(7):869-82. https://doi.org/10.5858/arpa.2017-0475-RA PMid:30672337 DOI: https://doi.org/10.5858/arpa.2017-0475-RA
Jalilian H, Ziaei M, Weiderpass E, Rueegg CS, Khosravi Y, Kjaerheim K. Cancer incidence and mortality among firefighters. Int J Cancer. 2019;145(10):2639-46. https://doi.org/10.1002/ijc.32199 PMid:30737784 DOI: https://doi.org/10.1002/ijc.32199
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, et al. Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021;19(3):329-59. https://doi.org/10.6004/jnccn.2021.0012 PMid:33724754 DOI: https://doi.org/10.6004/jnccn.2021.0012
Battaglin F, Naseem M, Lenz HJ, Salem ME. Microsatellite instability in colorectal cancer: Overview of its clinical significance and novel perspectives. Clin Adv Hematol Oncol. 2018;16(11):735-45. PMid:30543589
Ahn CH, Kim SC. Colorectal adenocarcinoma in children: Two case reports. Medicine (Baltimore). 2017;96(46):e8074. PMid:29145239 DOI: https://doi.org/10.1097/MD.0000000000008074
Costas-Chavarri A, Nandakumar G, Temin S, Lopes G, Cervantes A, Cruz Correa M, et al. Treatment of patients with early-stage colorectal cancer: ASCO resource-stratified guideline. J Glob Oncol. 2019;5:1-19. https://doi.org/10.1200/ JGO.18.00214 PMid:30802158 DOI: https://doi.org/10.1200/JGO.18.00214
Thygesen MK, Baatrup G, Petersen C, Qvist N, Kroijer R, Kobaek-Larsen M. Screening individuals’ experiences of colonoscopy and colon capsule endoscopy; a mixed methods study. Acta Oncol. 2019;58(Sup 1):S71-6. https://doi.org/10.1080/0284186X.2019.1581372 PMid:30821625 DOI: https://doi.org/10.1080/0284186X.2019.1581372
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Copyright (c) 2023 Evan Savero Widiono, Martahadinan, Chandra A. Tambunan, Sofa Primatir (Author)
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