The Average of Serum 25(OH)D in Children with Chronic Tonsillitis

Melati Sudiro; Arif Dermawan; Alfira Ulfa

doi:10.3889/oamjms.2023.11618

Authors

Melati Sudiro Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia https://orcid.org/0009-0006-4027-362X
Arif Dermawan Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
Alfira Ulfa Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2023.11618

Keywords:

Chronic tonsillitis, Vitamin D level, Serum 25(OH)D

Abstract

AIM: This study aims to determine serum 25(OH)D levels in children with chronic tonsillitis at Dr. Hasan Sadikin Bandung General Hospital.

METHODS: This descriptive and cross-sectional study was conducted in patients with chronic tonsillitis aged

3–15 years from August 26, 2021, to April 26, 2022. The exclusion criteria include children who consumed Vitamin D for the past month, are in ongoing treatment for chronic tonsillitis, and have comorbidities that affect Vitamin D serum. Characteristics were taken from anamnesis, while Vitamin D serum was analyzed using the ELISA method, then data were presented in numbers and percentages.

RESULTS: The average serum level of 25(OH)D was 16.43 ± 3.5 ng/mL. All 44 subjects suffered from a lack of Vitamin D, categorized as deficiency, insufficiency, and severe deficiency, at 72.7%, 22.7%, and 4.6%, respectively. The majority of the cases were boys compared to girls, with 70.5% and 29.5%, respectively.

CONCLUSION: All children with chronic tonsillitis were found to have 25(OH)D serum below the normal level, with an average of 16.43 ± 3.5 ng/mL, especially in boys aged 3–10 years.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Fakh IM, Novialdi N, Elmatris E. Characteristics of chronic tonsillitis children in the ENT-KL department of RSUP Dr. M. Djamil Padang 2013. J Health Andalas. 2016;5(2):436-42.

Bakar MA, McKimm J, Haque SZ, Majumder MA, Haque M.

Chronic tonsillitis, and biofilms: A brief overview of treatment modalities. J Inflamm Res. 2018;11:329-37. https://doi.org/10.2147/JIR.S162486 PMid:30233227 DOI: https://doi.org/10.2147/JIR.S162486

Haidara AW, Sidibé Y, Samaké D, Coulibaly A, Touré MK, Coulibaly BB, et al. Tonsillitis and their complications: Epidemiological, clinical and therapeutic profiles. Int J Otolaryngol Head Neck Surg. 2019;8(3):98-105. https://doi.org/10.4236/ijohns.2019.83011 DOI: https://doi.org/10.4236/ijohns.2019.83011

Mahfuz MS, Kabir MA. Sociodemographic characteristics of the patients of tonsillitis attended in OPD of a district level hospital. Bangladesh J Otorhinolaryngol. 2020;23(2):180-6. https://doi.org/10.3329/bjo.v23i2.45165 DOI: https://doi.org/10.3329/bjo.v23i2.45165

Ministry of Health Research and Development Agency. Results of Basic Health Research. 2018;57,58.

Mirza AA, Alharbi AA, Marzouki H, Al-Khatib T, Zawawi F. The association between Vitamin D deficiency and recurrent tonsillitis: A systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2020;163(5):883-91. https://doi.org/10.1177/0194599820935442 PMid:32689892 DOI: https://doi.org/10.1177/0194599820935442

Rao MS, Karade D. A clinical study of serum Vitamin D levels in chronic tonsillitis among the paediatric age group. Bengal J Otolaryngol Head Neck Surg. 2020;28(1):23-9. https://doi.org/10.47210/bjohns.2020.v28i1.21 DOI: https://doi.org/10.47210/bjohns.2020.v28i1.21

Yildiz I, Unuvar E, Zeybek U, Toptas B, Cacina C, Toprak S, et al. The role of Vitamin D in children with recurrent tonsillopharyngitis. Ital J Pediatr. 2012;38(1):25. https://doi.org/10.1186/1824-7288-38-25 PMid:22682426 DOI: https://doi.org/10.1186/1824-7288-38-25

Bergman P, Norlin AC, Hansen S, Rekha, RS Agerberth B, Björkhem-Bergman L, et al. Vitamin D3 supplementation in patients with frequent respiratory tract infections: A randomised and double-blind intervention study. BMJ Open. 2012;2(6):e001663. https://doi.org/10.1136/bmjopen-2012-001663 PMid:23242238 DOI: https://doi.org/10.1136/bmjopen-2012-001663

Aryani L, Riyandry M. Vitamin D as a potential therapy for children malnutrition. J Nurse Researcher Prof. 2019;1(1):61-70. https://doi.org/10.37287/jppp.v1i1.24 DOI: https://doi.org/10.37287/jppp.v1i1.24

Fiannisa R. Vitamin D as prevention of degenerative diseases to malignancy. medulla. 2019;9(3):385-92.

Sudiro M, Lestari BW, Madiadipoera T, Setiabudiawan B, Boesoirie TS. Vitamin D deficiency is correlated with the severity of allergic rhinitis. Open Access Lib J. 2017;4(8):1-9. https://doi.org/10.4236/oalib.1103813 DOI: https://doi.org/10.4236/oalib.1103813

Rahayu RD, Arief T, Anggraeni S. Characteristics of tonsillitis patients in children aged 5-12 years at RSPBA Bandar Lampung in 2020. Arteries J Health Sciences. 2021;2(1):30-5. https://doi.org/10.37148/arteri.v2i1.143 DOI: https://doi.org/10.37148/arteri.v2i1.143

Shalihat AO, Irawati L. Relationship between gender, tonsil size and management in chronic tonsilitis patients in ORL-HNS Clinic dr M. Djamil General Hospital Padang 2013. J Health Andalas. 2013;4(3):786-94. https://doi.org/10.25077/jka.v4i3.365 DOI: https://doi.org/10.25077/jka.v4i3.365

Önal M, Yilmaz T, Bilgiç E, Müftüoğlu SF, Kuşçu O, Günaydin RÖ. Apoptosis in chronic tonsillitis and tonsillar hypertrophy. Int J Pediatr Otorhinolaryngol. 2015;79(2):191-5. https://doi.org/10.1016/j.ijporl.2014.12.005 PMid:25555639 DOI: https://doi.org/10.1016/j.ijporl.2014.12.005

Malapane E, Solomon EM, Pellow J. Efficacy of a homeopathic complex on acute viral tonsillitis. J Altern Complement Med.

;20(11):868-73. https://doi.org/10.1089/acm.2014.0189 PMid:25238506 DOI: https://doi.org/10.1089/acm.2014.0189

Buname G, Kiwale GA, Mushi MF, Silago V, Rambau P, Mshana SE. Bacteria patterns on tonsillar surface and tonsillar core tissue among patients scheduled for tonsillectomy at Bugando medical centre, Mwanza, Tanzania. Pathogens. 2021;10(12):1560. https://doi.org/10.3390/pathogens10121560 PMid:34959515 DOI: https://doi.org/10.3390/pathogens10121560

Sapitri V. Karakteristik Penderita Tonsilitis Kronis Yang Diindikasikan Tonsilektomi Di RSUD Raden Mattaher Jambi. Fkik Unja. Vol. 12. Indonesia: Universitas Jambi; 2013. p. 67-72.

Safak AS, Bulut F, Cumbul A. Histopathological role of Vitamin D deficiency in recurrent/chronic tonsillitis pathogenesis: Vascular epithelial growth factor-mediated angiogenesis in tonsil. Clin Exp Dent Res. 2022;8(3):699-706. https://doi.org/10.1002/cre2.539 PMid:35213796 DOI: https://doi.org/10.1002/cre2.539

Esposito S, Lelii M. Vitamin D and respiratory tract infections in childhood. BMC Infect Dis. 2015;15(1):487. https://doi.org/10.1186/s12879-015-1196-1 PMid:26521023 DOI: https://doi.org/10.1186/s12879-015-1196-1

Wang Y, Zhu J, DeLuca HF. Where is the Vitamin D receptor? Arch Biochem Biophys. 2012;523(1):123-33. https://doi.org/10.1016/j.abb.2012.04.001 PMid:22503810 DOI: https://doi.org/10.1016/j.abb.2012.04.001

Nimitphong H, Holick MF. Vitamin D status and sun exposure in Southeast Asia. Dermatoendocrinol. 2013;5(1):34-7. https://doi.org/10.4161/derm.24054 PMid:24494040 DOI: https://doi.org/10.4161/derm.24054

Mohamed SH, Alizadeh S, Tessema M, Samuel A, Petros A, Hussen A. Clothing type and Vitamin D status: A systematic review and meta-analysis. Res Sq. 2021;25:1-13. https://doi.org/10.21203/rs.3.rs-376562/v1 24. McCrindle M, Fell A. Generation Alpha. Australia: McCrindle Research; 2020. p. 1-22.

Taylor SN. Vitamin D in toddlers, preschool children, and adolescents. Ann Nutr Metab. 2020;76(suppl 2):30-41. https://doi.org/10.1159/000505635 PMid:33232959 DOI: https://doi.org/10.1159/000505635