Neurologic Manifestation in Children with Coronavirus Disease 2019 at Prof. Dr. I.G.N.G Ngoerah Tertiary Hospital
DOI:
https://doi.org/10.3889/oamjms.2023.11619Keywords:
neurologic manifestation, COVID-19, childrenAbstract
AIM: The objective of the study is to describe neurologic manifestation in children with coronavirus disease-2019 (COVID-19) at Prof. Dr. I.G.N.G Ngoerah Hospital.
METHODS: This was a retrospective descriptive study using the medical record with a total sampling of children with confirmed COVID-19 that manifests neurologic symptoms. Exclusion criteria were pre-existing neurologic comorbidities and incomplete medical records.
RESULTS: From March 2020 to December 2021, from 308 children with confirmed cases of COVID-19, 106 had neurologic symptoms, 17 were excluded (16 pre-existing comorbidities, and 1 incomplete medical record), and total samples were 89 (28.8%) from inpatient and outpatient. Most children were male (57.3%) with a median age of 13 years. Most symptoms found were anosmia (73%), followed by a decrease in consciousness (19.1%) and seizure (10.1%). Children with anosmia median age were 14 years. There were 84 (94.3%) children with specific neurological symptoms (encephalopathy, seizures, and anosmia) and 5 (5.7%) with non-specific neurological symptoms (headache).
CONCLUSION: There were 28.8% confirmed cases of COVID-19 with a neurologic manifestation, and most symptoms found were anosmia (73%).
Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Direktorat Jenderal Pencegahan dan Pengendalian Penyakit. Pedoman Pencegahan dan Pengendalian Coronavirus Disease (COVID-19). Indonesia: Kementerian Kesehatan Republik Indonesia; 2020.
Perhimpunan Dokter Paru Indonesia, Perhimpunan Dokter Spesialis Kardiovaskular Indonesia, Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia, Perhimpunan Dokter Anestesiologi dan Terapi Intensif Indonesia, Ikatan Dokter Anak Indonesia. Pedoman Tatalaksana COVID-19 Edisi 3; 2020.
Vohora D, Jain S, Tripathi M, Potschka H. COVID-19 and seizures: Is there a link? Epilepsia 2020;61:1840-53. DOI: https://doi.org/10.1111/epi.16656
Stafstrom CE, Jantzie LJ. COVID-19: Neurological considerations in neonates and children. Children (Basel). 2020;7(9):133. https://doi.org/10.3390/children7090133 PMid:32927628 DOI: https://doi.org/10.3390/children7090133
Ray ST, Abdel-Mannan O, Sa M, Fuller C, Wood GK, Psyden K, et al. Neurological manifestations of SARS-CoV-2 infection in hospitalized children and adolescents in the UK: A perspective national cohort study. Lancet Child Adolesc Health 2021;5(9):631-41. https://doi.org/10.1016/S2352-4642(21)00193-0 PMid:34273304 DOI: https://doi.org/10.1016/S2352-4642(21)00193-0
Gurlevik SL, Gunbey C, Ozsurekci Y, Oygar PD, Kesici S, Gocmen R, et al. Neurologic manifestations in children with COVID-19 from a tertiary center in Turkey and literature review. Eur J Paediatr Nerurol. 2022;37:139-54. https://doi.org/10.1016/j.ejpn.2022.02.003 PMid:35287009 DOI: https://doi.org/10.1016/j.ejpn.2022.02.003
Aljomah L, Almedlej S, Baarmah D, Altwaijri W, Alrumayyan A, Alrifai MT. Pediatrics COVID-19 and neurological manifestations: Single tertiary centre experience. eNeurologicalSci. 2021;24:100355. https://doi.org/10.1016/j.ensci.2021.100355 PMid:34307923 DOI: https://doi.org/10.1016/j.ensci.2021.100355
Parisi GF, Brindisi G, Indolfi C, Diaferio L, Marchese G, Ghiglioni DG, et al. Upper airway involvement in pediatric COVID-19. Pediatr Allergy Immunol. 2020;31(Suppl 26):85-8. https://doi.org/10.1111/pai.13356 PMid:33236430 DOI: https://doi.org/10.1111/pai.13356
Panda PK, Sharawat IK, Panda P, Natarajan V, Bhakat R, Dawman L. Clinical review: Neurological complications of SARS-CoV-2 infection in children: A systematic review and meta-analysis. J Trop Pediatr. 2020;67(3):fmaa070. https://doi.org/10.1093/tropej/fmaa070 PMid:32910826 DOI: https://doi.org/10.1093/tropej/fmaa070
Lin JE, Asfour A, Sewell TB, Hooe B, Pryce P, Earley C, et al. Neurological issues in children with COVID-19. Neurosci Lett. 2020;743:135567. https://doi.org/10.1016/j.neulet.2020.135567.2020 PMid:33352286 DOI: https://doi.org/10.1016/j.neulet.2020.135567
Fink EL, Robertson CL, Wainwright MS, Roa JD, Lovett ME, Stulce C. Prevalence and risk factors of neurologic manifestations in hospitalized children diagnosed with acute SARS-CoV-2 or MIS-C. Pediatr Neurol. 2022;128:33-44. https://doi.org/10.1016/j.pediatrneurol.2021.12.010 PMid:35066369 DOI: https://doi.org/10.1016/j.pediatrneurol.2021.12.010
Kumar L, Kahlon N, Jain A, Kaur J, Singh M, Pandey AK. Loss of smell and taste in COVID-19 infection in adolescents. Int J Pediatr Otorhinolaryngol 2021;142:110626. https://doi.org/10.1016/j.ijporl.2021.110626 PMid:33477014 DOI: https://doi.org/10.1016/j.ijporl.2021.110626
Schober ME, Robertson CL, Wainwright MS, Roa JD, Fink EL.
COVID-19 and the pediatric nervous system: Global collaboration to meet a global need. Neuricrit Care. 2021;35(2):283-90. https://doi.org/10.1007/s12028-021-01269-2 PMid:34184177 DOI: https://doi.org/10.1007/s12028-021-01269-2
Kim YK, Walser SA, Asghar SJ, Jain R, Mainali G, Kumar A. A comprehensive review of neurologic manifestations of COVID-19 and management of pre-existing neurologic disorders in children. J Child Neurol. 2020;36(4):324-30. https://doi.org/10.1177/0883073820968995 PMid:33112694 DOI: https://doi.org/10.1177/0883073820968995
Govil-Dalela T, Sivaswamy L. Neurological effects of COVID-19 in children. Pediatr Clin North Am. 2021;68(5):1081-91. https://doi.org/10.1016/j.pcl.2021.05.010 PMid:34538300 DOI: https://doi.org/10.1016/j.pcl.2021.05.010
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2023 Michelle Husin, Dewi Sutriani Mahalini, I Gusti Ngurah Made Suwarba, Ni Putu Siadi Purniti, Ida Bagus Subanada (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0
