Correlation between Total Lymphocyte Count, C Reactive Protein, and Neutrophil Lymphocyte Ratio Levels with Gastrointestinal Manifestations in Covid-19 Patients Treated at Ulin Hospital, Banjarmasin

Bernadet Maria  Sanjaya; Achmad  Soefyani; Nanang Miftah  Fajari; Wiwit Agung Sri Nur   Cahyawati; Mohammad  Rudiansyah

doi:10.3889/oamjms.2023.11739

Authors

Bernadet Maria Sanjaya Department of Internal Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, Indonesia https://orcid.org/0000-0002-6829-715X
Achmad Soefyani Gastroenterohepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, Indonesia
Nanang Miftah Fajari Endocrine, Metabolic and Diabetes Division, Department of Internal Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, Indonesia
Wiwit Agung Sri Nur Cahyawati Geriatric Division, Department of Internal Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, Indonesia
Mohammad Rudiansyah Nephrology and Hypertension Division, Department of Internal Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, Indonesia https://orcid.org/0000-0002-5469-9641

DOI:

https://doi.org/10.3889/oamjms.2023.11739

Keywords:

c reactive protein, Total lymphocyte count, Neutrophil Lymphocyte Ratio, COVID-19, Gastrointestinal Manifestation

Abstract

BACKGROUND: Coronavirus disease can affect the digestive system and cause gastrointestinal manifestations. The increase in C-reactive protein (CRP) correlates with the severity of the disease. The neutrophil-to-lymphocyte ratio (NLR) is a useful prognostic factor in the early screening of patients with COVID-19. A low lymphocyte count can also predict gastrointestinal involvement.

AIM: This study aims to determine the correlation between TLC, CRP, and NLR levels on gastrointestinal manifestations in COVID-19 patients treated at Ulin General Hospital, Banjarmasin.

METHODS: This study used a cross-sectional design. Data were taken consecutively using the medical records of confirmed COVID-19 patients with gastrointestinal manifestations. The number of subjects in this study was 88 patients.

RESULTS: A decrease in TLC levels (<1740 g/dL) was not proven to have a significant correlation with gastrointestinal manifestations in COVID-19 patients (p = 0.176). Increased levels of CRP (>48 mg/L) had a significant correlation by 5.71 times compared to subjects who did not experience increased CRP (p < 0.00001). Increased levels of the NLR (>6 mg/L) had a significant correlation by 2.82 times compared to subjects who did not experience an increase in NLR (p = 0.032).

CONCLISION: An increase in CRP levels >48 mg/L and levels of NLR >6, respectively, allowed the subject to experience gastrointestinal symptoms by 5.71 times and 2.82 times when infected with COVID-19, while a decrease in total lymphocyte count <1740 was not proven to have a significant correlation with gastrointestinal manifestations.

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